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UCSF Cardiology
Transforming medicine through innovation and collaboration.
Department of Medicine

Comprehensive Genetic Arrhythmia Program

Working Together for the Health of Your Heart

The mission of the Comprehensive Genetic Arrhythmia Program (CGAP) is to study and treat inherited heart rhythm disorders. Such disorders are also known as arrhythmias. While not all arrhythmias are genetic in nature, arrhythmias as a class represent a serious health risk. The most serious risk with arrhythmias is that of sudden cardiac death (SCD). Annually, nearly 500,000 deaths are attributed to SCD. Through its research, CGAP aims to provide a leadership role in the process of understanding existing genetic causes of cardiac arrhythmias, identifying new candidate genes, and applying this knowledge to improving partient care.

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Experts in electrophysiology, cardiology, genetics, and genetic counseling work side-by-side to provide a multi-disciplinary focus not found anywhere else in the western United States. This focus is a significant benefit to both patients and their physicians for several key reasons:

  • Genetic causes of SCD can be rare and difficult to diagnose, and individual physicians often have limited experience recognizing such conditions. Our research team includes some of the the world's leading experts in inherited arrhythmias. Our expertise is available as a consultative service.
  • Inherited arrhythmias can affect not only the patient, but other family members as well, creating unique challenges in patient/family management. This is another area in which individual physicians can benefit from the experience of our experts. Our multi-disciplinary evaluations are designed to ensure that all patients and their families receive the best, most comprehensive evaluation possible.
  • Genetic testing and genetic counseling are recognized as critical components in making the right diagnosis, planning treatment, and helping patients and their families adjust to life with an inherited arrhythmia. For this reason, research genetic analysis and research genetic counseling is an integral part of our research efforts. It is also an important tool for researchers themselves, as inherited arrhythmias can only be understood within the context of family relationships.
  • Current advances in our understanding of the role that genetic mutations play in inherited arrhythmias reinforce the importance of patient/family management and the benefit of ready access to information from prior genetic studies. UCSF has a vast store of research data. CGAP intends to continue and extend this commitment as the boundaries of what we know expand.
Conditions Studied by CGAP

CGAP will study patients with:

  • Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy (ARVD/C)
  • Brugada Syndrome
  • Long QT Syndrome (LQTS)
  • Short QT Syndrome
  • Catecholamine-induced Polymorphic Ventricular Tachycardia (CPVT)
  • Aborted sudden death of uncertain etiology
The Power of Community

The goal of this website is to provide patients, their family members, their care-givers, and educators a place to turn for information, treatment options, and referrals. Here you will find information describing:

We hope you will use this site to help you better understand the implications of these complex genetic conditions. Our research will take "the hands and hearts"—and heads—of all of us to succeed. Your ideas are welcome. Please share them with us at cgap_study@ucsf.edu.