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UCSF Cardiology
Transforming medicine through innovation and collaboration.
Department of Medicine

Core Lab Activities

The UCSF Quantitative Echocardiography Core Laboratory

General Overview

The UCSF Quantitative Echocardiography Core Laboratory (ECL) has been in existence for over 25 years and helped to pioneer the use of emerging echocardiographic technologies, including MD mode, 2D, and 3D echo. We have been involved in a number of landmark clinical trials and have recognized expertise especially in the areas of dyssynchrony, LV function assessment and assessment of valvular heart disease.

We offer a number of services that include:

Our lab has access to some of the world’s experts in cardiovascular disease, heart failure and electrophysiology which we leverage in designing new protocols for sponsors.

We use only highly trained senior sonographer/technicians to perform quantitative measurements. All studies are formally reviewed and read by experienced, board-certified echocardiologists.

Our lab understands the time, effort and cost burdens of assessing both research and clinical echocardiograms and strives to design echocardiography protocols which are parsimonious yet help answer all the relevant clinical question(s) or study aims. We are able to be highly competitive in pricing with many commercially available core labs due to staffing and support from the UCSF Division of Cardiology.

We follow the most recent American Society of Echocardiography Standards and conduct all of our operations under FDA guidelines and Good Clinical Practice.

If your company is looking for a central laboratory to perform any of the above services for a new study, please contact the ECL Director, Atif Qasim. MD, MSCE at atif.qasim@ucsf.edu.

Electrocardiography Core Laboratory

General Overview

Under the direction of Byron Lee, MD, and Thomas Everett, PhD, the Electrocardiography Core Lab (ECGL) conducts all its operations under FDA guidelines and Good Clinical Practice. The ECGL can serve as the central laboratory that will independently analyze 12-Lead ECG, signal averaged ECG, P-wave ECG, Holter, stress test, and Baroreflex Sensitivity (BRS) studies performed by participating centers. Sample studies are reviewed from each of the participating sites and feedback is provided to the center to ensure that quality signals are collected with low signal to noise ratios for accurate analysis, and to ensure adherence to the protocol.

Scope of Work

The ECGL will provide a reproducible, qualitative and quantitative analysis of all data. At the request of the study sponsor, the ECGL will develop a Statement of Work document that will outline the sponsor’s expectations, the protocol requirements, and the ECGL’s responsibilities and the scope of work for the trial.

Quality Analysis

All data that comes into the ECG Core will be subject to quality control. Data from each of the tests that are involved in the study will be viewed for noise and data variability. The 12-Lead ECG, signal averaged ECG, P-wave ECG, Holter, and stress test are analyzed using GE Healthcare analysis programs (MUSE – ECG, MARS – Holter, Cardiosoft – stress test). Baroreflex Sensitivity (BRS) studies are analyzed using Task Force Monitor and custom Matlab programs.