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UCSF Cardiology
Transforming medicine through innovation and collaboration.
Department of Medicine

General Cardiology Research

Ongoing UCSF Investigator-Initiated Studies

Title: Novel risk markers in primary prevention of coronary artery disease
Principal Investigator: Kirsten Fleischmann, MD, MPH
Purpose: To assess the comparative effectiveness and cost-effectiveness of newer risk markers for refining risk stratification for coronary artery disease in asymptomatic individuals.

Title: Coronary Artery Disease Detection by Quantitative Electrocardiographic Detector (QED)
Principal Investigator: Gordon Fung, MD
Co-Investigator: Eli Botvinick, MD
Purpose: Evaluate new parameters on resting 12 lead ECG for ischemia detection with stress perfusion imaging and coronary angiography as the “gold” standard.

Title: Dynamic cardiac SPECT
Principal Investigator: Eli Botvinick, Grant Gullberg, PhD
Purpose: NIH funded project to develop clinical methods for quantitation of coronary flow and flow reserve on perfusion SPECT imaging as currently available for PET methods

Title: The Heart and Soul Study
Principal Investigator: Mary Whooley, MD, FACP, FAHA, FACC
Purpose: Prospective cohort study of 1000 patients with coronary heart disease who have been followed for 10 years.

Title: High sensitivity Troponin T as a novel predictor of cardiovascular events in the Heart and Soul Study
Faculty sponsor/mentor : Mary A. Whooley, MD
Purpose: This project aims to determine whether measurement of a novel biomarker, high-sensitivity cardiac Troponin T, predicts future cardiovascular events in patients with stable ischemic heart disease, which will serve to refine our ability to predict and prevent events in this population.

Title: An Economic Framework for Evaluating Biomarkers Used to Target CVD Prevention
Principal Investigator: Mark Pletcher
Purpose: “Heart scans” for coronary calcium and other newly discovered tests (“biomarkers”) can help identify persons at risk for heart attacks and stroke who should be treated with medications to lower their risk. By estimating how many heart attacks, strokes and deaths could be prevented by using these tests routinely in the U.S. and how much money this would cost, our study will help policymakers decide when doctors should order a heart scan or other biomarker test.

Title: The Social Heart Study: Phase I Pilot
Principal Investigator: Mark Pletcher
Purpose: The Social Heart Study is an online social network-based cardiovascular research study designed to discover how social networks contribute to cardiovascular health, and to discover new ways of preventing cardiovascular disease.

Title: Symptoms in Arrhythmia Symptom (Measurement in Patients with Arrhythmias)
Principal Investigator: Kathy Wood, NP, PhD
Purpose: : Test the newly developed Patient Perspective of Arrhythmia Questionnaire (PPAQ) in atrial fibrillation [AF], supraventricular tachycardia [SVT], or ventricular tachycardia [VT] patients

Ongoing Participation in Multicenter Clinical Trial and Registries

Title: A Phase 3, Open-Label, Multi-Center Study for the Assessment of Myocardial Perfusion using Positron Emission Tomography (PET) Imaging of Flurpiridaz F 18 Injection in Patients with Suspected or Known Coronary Artery Disease (CAD)
Site Principal Investigator: Eli Botvinick, MD
Purpose: Multi-Center Phase III Clinical Trial of new PET F-18 based perfusion agent compared with current SPECT perfusion methods and coronary angiography.

Title: Variations in Care: Comparing Heart Failure Care Transition Intervention Effects (BEAT-HF)
Site Principal Investigator: Andrew D Auerbach, MD, MPH
Site Co-Investigator: Teresa De Marco, MD, FACC
Purpose: Randomized multi-Center trial of University of California Hospitals and Cedar Sinai Medical Center to assess telemangement intervention on outcomes in patients admitted with heart failure