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UCSF Cardiology
Transforming medicine through innovation and collaboration.
Department of Medicine

Fellow Research Projects

Title: High sensitivity Troponin T as a novel predictor of cardiovascular events in the Heart and Soul Study
Purpose: This project aims to determine whether measurement of a novel biomarker, high-sensitivity cardiac Troponin T, predicts future cardiovascular events in patients with stable ischemic heart disease, which will serve to refine our ability to predict and prevent events in this population.
Principal Investigator/Fellow: Alexis Beatty, MD
Faculty sponsor/mentor: Mary A. Whooley, MD
Funding: NIH/NHLBI F32HL110518-01 (NRSA)

Title: Using a Novel Automated Software Algorithm to Evaluate Left Atrial Tissue Characteristics Using Computed Tomography
Purpose: The purpose of this project is to investigate the ability of a new software algorithm to define the left atrial wall thickness and density in those with and without atrial fibrillation and, among atrial fibrillation patients, those with successful and failed ablation procedures. The left atrial wall characteristics will also be compared to tissue thickness and content of fibrosis obtained from autopsy specimens.
Principal Investigator/Fellow: Thomas Dewland, MD
Faculty sponsor/mentor: Gregory M. Marcus, MD
Funding: UCSF Atrial Fibrillation Cohort Fund

Title: Body Mass Index and Cardiac Rhythm Device Implantation: Complications, Intention and Success
Purpose: The purpose of this project is to investigate an association of body habitus (as measured by body mass index) with complications, mortality and length of hospital stay in patients undergoing implantable cardioverter defibrillator implantation. The project also seeks to evaluate an association of body mass index with attempted cardiac resynchronization therapy implantation and success.
Principal Investigator/Fellow: Jonathan Hsu, MD
Faculty sponsor/mentor: Gregory M. Marcus, MD
Funding: This research is supported by the American College of Cardiology Foundation's National Cardiovascular Data Registry (NCDR).

Title: Sudden Cardiac Death and Ventricular Arrhythmias in Patients with HIV
Principal Investigator/Fellow: Brian Moyers, MD
Faculty sponsor/mentor: Zian H. Tseng, MD, MAS
Purpose: We propose to evaluate pathologic ECG parameters and the type and quantity of ventricular arrhythmias in HIV-infected individuals with and without known cardiovascular disease. We will also evaluate the association of inflammatory markers and HIV-related factors with SCD in an outpatient cohort of HIV-infected individuals

Title: Refining a Genetic Association Signal in Calsequetrin 2 in Risk of Sudden Cardiac Death/Arrest in Patients with Coronary Artery Disease
Principal Investigator/Fellow: Marwan Refaat, MD
Faculty sponsor/mentor: Zian H. Tseng, MD, MAS
Purpose: The project is an attempt to validate preliminary data in support of a potential association between single nucleotide polymorphisms in the human calsequestrin 2 gene and increased risk of sudden cardiac death/arrest due to ventricular tachycardia /ventricular fibrillation in patients with a history of myocardial infarction.
Funding: Heart Rhythm Society Kenneth M. Rosen Research Fellowship Award, 2011-2012

Title: Electrocardiographic Imaging in the evaluation of cardiac resynchronization therapy
Principal Investigators: Kurt S. Hoffmayer, MD (fellow) and Melvin Scheinman, MD
Purpose: To compare electrical and mechanical synchrony in the patients who have undergone cardiac resynchronization therapy device implantation.

Title: Prospective Evaluation of ECG Criteria to distinguish ARVD/C from RVOT-VT
Principal Investigators: Kurt S. Hoffmayer, MD (fellow) and Melvin Scheinman, MD
Purpose: To predict the diagnosis of ARVD/C by ECG criteria from RVOT-VT.

Title: Electrocardiographic Imaging in patients with Brugada Syndrome
Principal Investigators: Kurt S. Hoffmayer, MD (fellow) and Melvin Scheinman, MD
Purpose: To evaluate non-invasive epicardial ventricular resynchronization using ECGI in patients with Brugada Syndrome