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UCSF Cardiology
Transforming medicine through innovation and collaboration.
Department of Medicine

Electrophysiology and Arrhythmias Research


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Ongoing UCSF Investigator-Initiated Studies

Title: Use of 3-D Blood Pool Scintigraphy to guide left ventricular pacing lead placement in patients requiring cardiac resynchronization therapy (MUGA CRT)
Principal Investigator: Nitish Badhwar, MD and Elias Botvinick, MD
Purpose: To improve the clinical response in patients with advanced heart failure by utilizing a Multiple Gated Acquisition Scan to guide the implantation of biventricular pacemaker.

Title: Nanostim Telemetry Feasibility Study
Principal Investigator: Nitish Badhwar, MD
Purpose: The purpose of this study is to study how small electrical signals flow between various electrodes in your body.

Title: TRAnsseptal needle VERSus radiofrequency Energy for Left Atrial access (TRAVERSE-LA): a randomized controlled trial
Principal Investigator: Gregory Marcus, MD, MAS
Purpose: To compare the effectivess, safety, and speed to a radiofrequency device versus conventional needle for transseptal access during catheter ablation procedures

Title: Investigating a Viral Etiology of Lone Atrial Fibrillation
Principal Investigator: Gregory Marcus, MD, MAS
Purpose: A study funded by the American Heart association to perform novel assays for the presence of viral infection on left atrial appendage samples RNA from lone atrial fibrillation patients undergoing epicardial ablation procedures

Title: Serologic Markers of Inflammation and Fibrosis in Atrial Fibrillation
Principal Investigator: Gregory Marcus, MD, MAS
Purpose: To creat a cohort of electrophysiology patients in order to bank serum, DNA, and RNA and investigate the relationship between inflammation, fibrosis, genetic determinants, and atrial tissue characteristics atrial fibrillation, atrial flutter, and supraventricular arrhythmia (SVT) patients

Title: Genetics of Cardiac Arrhythmias
Principal Investigator:Dr. Melvin Scheinman
Purpose: The primary objective of this study is to advance the characterization of the genetic and clinical aspects of 6 inherited genetic arrhythmia syndromes:

  1. Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy (ARVD/C);
  2. Long QT syndrome (LQTS);
  3. Short QT syndrome;
  4. Brugada syndrome;
  5. Cathecholaminergic Polymorphic Ventricular Tachycardia (CPVT);
  6. Other hereditary arrhythmia syndromes that present as aborted sudden death of uncertain etiology.

Title: Comprehensive Autopsy Characterization of Sudden Cardiac Death
Principal Investigator: Zian H. Tseng, M.D., M.A.S
Purpose: Comprehensive autopsy evaluation of all consecutive incident sudden cardiac deaths (SCDs) and a frequency-matched sample of accidental trauma controls to determine contemporary rates of SCD and arrhythmic sudden death and its risk factors in a diverse community (San Francisco County).

Title: Evaluation of Genetic Risk Factors for Sudden Cardiac Arrest
Principal Investigator:Zian H. Tseng, M.D., M.A.S.
Purpose: Comparison of Single nucleotide polymorphisms in candidate genes and genome wide scan in patients with history sudden cardiac arrest in the setting of coronary artery disease (CAD) compared to CAD control patients.

Title: Incidence of Sudden Neurologic Death
Principal Investigator: Anthony Kim, M.D., M.A.S. (Neurology faculty)
Co-Investigator: Zian H. Tseng, M.D., M.A.S.
Purpose: To systematically evaluate the incidence of acute neurologic causes of death in a consecutive and comprehensive series of cases of sudden cardiac death cases within a well-defined multi-ethnic geographic study base.

Ongoing Participation in Multicenter Clinical Trial and Registries

Title: Permanent Left Auricular Closure & Exclusion in Patients with Atrial Fibrillation Protocol (PLACE III Registry)
Site Principal Investigator: Gregory Marcus, MD, MAS
Site Principal Investigator: Nitish Badhwar, MD
Purpose: The primary objectives of this registry is to demonstrate that complete LAA exclusion can be achieved percutaneously as a stand alone procedure with the LARIAT Suture Delivery Device, SureCUT, EndoCATH and FindrWIRZ components safely with a percutaneous approach.

Title: Catheter Ablation Versus Antiarrhythmic Drug Therapy for Atrial Fibrillation Trial (CABANA Trial)
Site Principal Investigator: Nitish Badhwar. MD
Purpose: Test the hypothesis that the treatment strategy of left atrial catheter ablation for the purpose of eliminating atrial fibrillation (AF) will be superior to current state-of-the-art therapy with either rate control or rhythm control drugs for reducing total mortality in patients with untreated or incompletely treated AF.

Title: Echocardiography Guided Cardiac Resynchronization Therapy (EchoCRT)
Site Principal Investigator: Nitish Badhwar, MD
Purpose: Evaluates the effects of Cardiac Resynchronization Therapy (CRT) on mortality and morbidity of subjects with heart failure due to left ventricular systolic dysfunction, already receiving optimized HF medication, with a narrow QRS width (< 130 ms) and echocardiographic evidence of ventricular dyssynchrony.

Title: Heartlight Study for the Treatment of Atrial Fibrillation
Site Principal Investigator: Edward Gerstenfeld, MD
Purpose: A multi-Center prospective randomized study comparing catheter ablation using a novel endoscopic laser balloon catheter (heartlight) and standard irrigated radiofrequency catheter.

Title: ACT V
Site Principal Investigator: Gregory Marcus, MD , MAS
Purpose: A phase 3b, randomized, double-blind, placebo-controlled, parallel group study to evaluate the safety and efficacy of vernakalant hydrochloride injection in patients with recent onset symptomatic atrial fibrillation

Title: Vests prevention and Early Sudden death Trial (VEST)
Study PI: Jeffery Olgin, MD
Site PI: Gregory Marcus, MD, MAS
Purpose: To conduct a multi-Center, randomized controlled trial to test the hypothesis that a non-nvasive wearable cardioverter defibrillator (WCD) will reduce sudden death and death due to ventricular arrhythmia in the first 90 days following an MI in participants with left ventricular dysfunction (EF≤35%), and to create a registry of VEST eligible patients for long-term follow-up to determine health and utilization outcomes.

Title: Safety of Sports for Patients with Implantable Cardioverter-Defibrillators: A multi-Center Study (Coordinating center is Yale University Department of Medicine)
Site Principal Investigator: Dr. Melvin Scheinman
Purpose: To determine the safety of sports participation for patients with ICDs.
Hypothesis: The incidence of serious adverse events occurring during sports, defined as:

  1. Tachyarrhythmia death (due to failure to convert VT/VF or post-shock PEA) or externally resuscitated arrest; or
  2. Significant injury due to syncopal arrhythmia or shock, will be less than 1% over 2 years in patients with ICDs who participate in vigorous sports activities.