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UCSF Cardiology
Transforming medicine through innovation and collaboration.
Department of Medicine

Faculty Profiles

Vasanth Vedantham
M_MED-CARD-CORE
Assistant Professor

555 Mission Bay Blvd South
San Francisco, CA 94158

Vasanth.Vedantham@ucsf.edu

CLINICAL INTERESTS: Dr. Vedantham is cardiologist and clinical cardiac electrophysiologist, specializing in treatment of heart rhythm disorders using catheter ablation, pacemaker and defibrillator implantation, and antiarrhythmic medications. Specific conditions include supraventricular tachycardia, atrial fibrillation, atrial flutter, ventricular tachycardia, bradycardia, syncope, and sudden cardiac death. He also implants biventricular devices for cardiac resynchronization therapy in patients with heart failure.


RESEARCH INTERESTS: Dr. Vedantham's research focuses on the molecular biology of the electrical system of the heart. His specific area of interest is understanding how transcription factors, microRNAs, and other regulatory molecules cooperatively determine the electrical properties of different types of heart cell by controlling the differential expression of ion channels in normal development and in heart disease. To address this problem, Dr. Vedantham combines molecular biology techniques with electrophysiological studies in genetically engineered mouse models. His goal is to make advances in basic cardiovascular science that will lead to improvements in the treatment and prevention of arrhythmias.

Education and Training

Location Degree or Training Specialty Date
Harvard University M.D. School of Medicine 2002
University of California, San Francisco Clinical Fellowship School of Medicine - Cardiology

Related Web Sites

In the News

Recent Articles (29)

Guo X, Vittinghoff E, Vedantham V, Pletcher MJ, Lee BK. Trends in Hospitalizations for Cardiac Sarcoidosis in the United States, 2005-2011. Circ J. 2017 Sep 13.

Vedantham V, Scheinman MM. Familial inappropriate sinus tachycardia: a new chapter in the story of HCN4 channelopathies. Eur Heart J. 2017 Jan 21; 38(4):289-291.

Nguyen KT, Gladstone RA, Dukes JW, Nazer B, Vittinghoff E, Badhwar N, Vedantham V, Gerstenfeld EP, Lee BK, Lee RJ, Tseng ZH, Olgin JE, Scheinman MM, Marcus GM. The QT Interval as a Noninvasive Marker of Atrial Refractoriness. Pacing Clin Electrophysiol. 2016 Oct 18.

Vedantham V. New Approaches to Biological Pacemakers: Links to Sinoatrial Node Development. Trends Mol Med. 2015 Dec; 21(12):749-61.

Hoffmayer KS, Lee BK, Vedantham V, Bhimani AA, Cakulev IT, Mackall JA, Sahadevan J, Rho RW, Scheinman MM. Response to letter regarding article, "variable clinical features and ablation of manifest nodofascicular/ventricular pathways". Circ Arrhythm Electrophysiol. 2015 Aug; 8(4):995.

Ito H, Kawamura M, Badhwar N, Vedantham V, Tseng ZH, Lee BK, Lee RJ, Marcus GM, Gerstenfeld EP, Scheinman MM. The Effect of Direct Current Stimulation versus T-Wave Shock on Defibrillation Threshold Testing. Pacing Clin Electrophysiol. 2015 Oct; 38(10):1173-80.

Kawamura M, Hsu JC, Vedantham V, Marcus GM, Hsia HH, Gerstenfeld EP, Scheinman MM, Badhwar N. Clinical and electrocardiographic characteristics of idiopathic ventricular arrhythmias with right bundle branch block and superior axis: Comparison of apical crux area and posterior septal left ventricle. Heart Rhythm. 2015 Jun; 12(6):1137-44.

Vedantham V, Galang G, Evangelista M, Deo RC, Srivastava D. RNA sequencing of mouse sinoatrial node reveals an upstream regulatory role for Islet-1 in cardiac pacemaker cells. Circ Res. 2015 Feb 27; 116(5):797-803.

Hoffmayer KS, Lee BK, Vedantham V, Bhimani AA, Cakulev IT, Mackall JA, Sahadevan J, Rho RW, Scheinman MM. Variable clinical features and ablation of manifest nodofascicular/ventricular pathways. Circ Arrhythm Electrophysiol. 2015 Feb; 8(1):117-27.

Kawamura M, Gerstenfeld EP, Vedantham V, Rodrigues DM, Burkhardt JD, Kobayashi Y, Hsia HH, Marcus GM, Marchlinski FE, Scheinman MM, Badhwar N. Idiopathic ventricular arrhythmia originating from the cardiac crux or inferior septum: epicardial idiopathic ventricular arrhythmia. Circ Arrhythm Electrophysiol. 2014 Dec; 7(6):1152-8.

Hua LL, Vedantham V, Barnes RM, Hu J, Robinson AS, Bressan M, Srivastava D, Black BL. Specification of the mouse cardiac conduction system in the absence of Endothelin signaling. Dev Biol. 2014 Sep 15; 393(2):245-54.

Singh DK, Viswanathan MN, Tanel RE, Lee RJ, Lee BK, Marcus GM, Olgin JE, Han F, Vedantham V, Tseng ZH, Pellegrini C, Kawamura M, Gerstenfeld EP, Badhwar N, Scheinman M. His overdrive pacing during supraventricular tachycardia: a novel maneuver for distinguishing atrioventricular nodal reentrant tachycardia from atrioventricular reciprocating tachycardia. Heart Rhythm. 2014 Aug; 11(8):1327-35.

Stepanyan G, Badhwar N, Lee RJ, Marcus GM, Lee BK, Tseng ZH, Vedantham V, Olgin J, Scheinman M, Gerstenfeld EP. Safety of new oral anticoagulants for patients undergoing atrial fibrillation ablation. J Interv Card Electrophysiol. 2014 Jun; 40(1):33-8.

Kawamura M, Badhwar N, Vedantham V, Tseng ZH, Lee BK, Lee RJ, Marcus GM, Olgin JE, Gerstenfeld EP, Scheinman MM. Coupling interval dispersion and body mass index are independent predictors of idiopathic premature ventricular complex-induced cardiomyopathy. J Cardiovasc Electrophysiol. 2014 Jul; 25(7):756-62.

Kawamura M, Vedantham V, Dewland TA, Scheinman MM. Incessant long RP tachycardia: what is the mechanism? Heart Rhythm. 2014 May; 11(5):904-6.

Hsu JC, Badhwar N, Gerstenfeld EP, Lee RJ, Mandyam MC, Dewland TA, Imburgia KE, Hoffmayer KS, Vedantham V, Lee BK, Tseng ZH, Scheinman MM, Olgin JE, Marcus GM. Randomized trial of conventional transseptal needle versus radiofrequency energy needle puncture for left atrial access (the TRAVERSE-LA study). J Am Heart Assoc. 2013 Oct; 2(5):e000428.

Vedantham V, Jackman WM, Scheinman MM. Unexpected potential following ablation of a right atriofascicular accessory pathway. J Cardiovasc Electrophysiol. 2013 Aug; 24(8):939-41.

Vedantham V, Evangelista M, Huang Y, Srivastava D. Spatiotemporal regulation of an Hcn4 enhancer defines a role for Mef2c and HDACs in cardiac electrical patterning. Dev Biol. 2013 Jan 1; 373(1):149-62.

Scheinman MM, Vedantham V. Ivabradine: a ray of hope for inappropriate sinus tachycardia. J Am Coll Cardiol. 2012 Oct 9; 60(15):1330-2.

Qian L, Huang Y, Spencer CI, Foley A, Vedantham V, Liu L, Conway SJ, Fu JD, Srivastava D. In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes. Nature. 2012 May 31; 485(7400):593-8.

Mandyam MC, Vedantham V, Scheinman MM, Tseng ZH, Badhwar N, Lee BK, Lee RJ, Gerstenfeld EP, Olgin JE, Marcus GM. Alcohol and vagal tone as triggers for paroxysmal atrial fibrillation. Am J Cardiol. 2012 Aug 1; 110(3):364-8.

Hsu JC, Badhwar N, Lee BK, Vedantham V, Tseng ZH, Marcus GM. Predictors of fluoroscopy time and procedural failure during biventricular device implantation. Am J Cardiol. 2012 Jul 15; 110(2):240-5.

Ieda M, Fu JD, Delgado-Olguin P, Vedantham V, Hayashi Y, Bruneau BG, Srivastava D. Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell. 2010 Aug 6; 142(3):375-86.

Vedantham V, Tseng ZH. Changing QRS Morphology in a Patient with Wolff-Parkinson-White Syndrome. Card Electrophysiol Clin. 2010 Jun; 2(2):239-243.

Zhao Y, Ransom JF, Li A, Vedantham V, von Drehle M, Muth AN, Tsuchihashi T, McManus MT, Schwartz RJ, Srivastava D. Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell. 2007 Apr 20; 129(2):303-17.

Vedantham V, Cannon SC. Rapid and slow voltage-dependent conformational changes in segment IVS6 of voltage-gated Na(+) channels. Biophys J. 2000 Jun; 78(6):2943-58.

Vedantham V, Cannon SC. The position of the fast-inactivation gate during lidocaine block of voltage-gated Na+ channels. J Gen Physiol. 1999 Jan; 113(1):7-16.

Vedantham V, Cannon SC. Slow inactivation does not affect movement of the fast inactivation gate in voltage-gated Na+ channels. J Gen Physiol. 1998 Jan; 111(1):83-93.

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