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UCSF Cardiology
Transforming medicine through innovation and collaboration.
Department of Medicine

Faculty Profiles

William Grossman, MD

555 Mission Bay Blvd South
San Francisco, CA 94158

CLINICAL INTERESTS; Dr. Grossman is a cardiologist and director of the Center for Prevention of Heart and Vascular Disease at Mission Bay. He is the Charles and Helen Schwab Endowed Chair in Preventive Cardiology at UCSF and a former chief of Cardiology at UCSF Medical Center. He specializes in treatments to prevent the development or progression of heart disease and cares for patients with hypertension (high blood pressure), dyslipidemia (abnormal cholesterol), coronary artery disease (previous or recent heart attack and angina), valvular heart disease, atrial fibrillation, cardiomyopathy and heart failure.

RESEARCH INTERESTS; Dr. Grossman has been a pioneer in research on diastolic function of the heart, and causes of cardiac muscle hypertrophy. He has also done research on the development of new treatments for heart failure, and valvular heart disease. He is editor of the textbook "Grossman's Cardiac Catheterization, Angiography and Intervention," which remains a standard in the field.

Education and Training

Location Degree or Training Specialty Date
Yale University M.D. School of Medicine 1965

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Recent Articles (165)

Grossman W, Paulus WJ. Myocardial stress and hypertrophy: a complex interface between biophysics and cardiac remodeling. J Clin Invest. 2013 Sep; 123(9):3701-3.

Prochaska JJ, Grossman W, Young-Wolff KC, Benowitz NL. Validity of self-reported adult secondhand smoke exposure. Tob Control. 2015 Jan; 24(1):48-53.

Ye J, Boyle A, Shih H, Sievers RE, Zhang Y, Prasad M, Su H, Zhou Y, Grossman W, Bernstein HS, Yeghiazarians Y. Sca-1+ cardiosphere-derived cells are enriched for Isl1-expressing cardiac precursors and improve cardiac function after myocardial injury. PLoS One. 2012; 7(1):e30329.

Wang X, Takagawa J, Haddad DJ, Pinnamaneni K, Zhang Y, Sievers RE, Grossman W, Yeghiazarians Y, Springer ML. Advanced Donor Age Impairs Bone Marrow Cell Therapeutic Efficacy for Cardiac Disease. J Tissue Sci Eng. 2011 Nov 18; S3.

Salti SM, Hammelev EM, Grewal JL, Reddy ST, Zemple SJ, Grossman WJ, Grayson MH, Verbsky JW. Granzyme B regulates antiviral CD8+ T cell responses. J Immunol. 2011 Dec 15; 187(12):6301-9.

Prochaska JJ, Benowitz NL, Glantz SA, Hudmon KS, Grossman W. Cardiology Rx for Change: improving clinical attention to tobacco use and secondhand smoke exposure in cardiology. Clin Cardiol. 2011 Dec; 34(12):738-43.

Angeli FS, Amabile N, Shapiro M, Mirsky R, Bartlett L, Zhang Y, Virmani R, Chatterjee K, Boyle A, Grossman W, Yeghiazarians Y. Cytokine combination therapy with erythropoietin and granulocyte colony stimulating factor in a porcine model of acute myocardial infarction. Cardiovasc Drugs Ther. 2010 Dec; 24(5-6):409-20.

Heiss C, Schanz A, Amabile N, Jahn S, Chen Q, Wong ML, Rassaf T, Heinen Y, Cortese-Krott M, Grossman W, Yeghiazarians Y, Springer ML. Nitric oxide synthase expression and functional response to nitric oxide are both important modulators of circulating angiogenic cell response to angiogenic stimuli. Arterioscler Thromb Vasc Biol. 2010 Nov; 30(11):2212-8.

Zhang Y, Sievers RE, Prasad M, Mirsky R, Shih H, Wong ML, Angeli FS, Ye J, Takagawa J, Koskenvuo JW, Springer ML, Grossman W, Boyle AJ, Yeghiazarians Y. Timing of bone marrow cell therapy is more important than repeated injections after myocardial infarction. Cardiovasc Pathol. 2011 Jul-Aug; 20(4):204-12.

Heiss C, Jahn S, Taylor M, Real WM, Angeli FS, Wong ML, Amabile N, Prasad M, Rassaf T, Ottaviani JI, Mihardja S, Keen CL, Springer ML, Boyle A, Grossman W, Glantz SA, Schroeter H, Yeghiazarians Y. Improvement of endothelial function with dietary flavanols is associated with mobilization of circulating angiogenic cells in patients with coronary artery disease. J Am Coll Cardiol. 2010 Jul 13; 56(3):218-24.

Angeli FS, Smith C, Amabile N, Shapiro M, Bartlett L, Virmani R, Chatterjee K, Boyle A, Grossman W, Yeghiazarians Y. Granulocyte colony stimulating factor in myocardial infarction with low ejection fraction. Cytokine. 2010 Sep; 51(3):278-85.

Tomita-Mitchell A, Mahnke DK, Larson JM, Ghanta S, Feng Y, Simpson PM, Broeckel U, Duffy K, Tweddell JS, Grossman WJ, Routes JM, Mitchell ME. Multiplexed quantitative real-time PCR to detect 22q11.2 deletion in patients with congenital heart disease. Physiol Genomics. 2010 Sep; 42A(1):52-60.

Kelly ME, Juern AM, Grossman WJ, Schauer DW, Drolet BA. Immunosuppressive effects in infants treated with corticosteroids for infantile hemangiomas. Arch Dermatol. 2010 Jul; 146(7):767-74.

Yeghiazarians Y, Khan M, Angeli FS, Zhang Y, Jahn S, Prasad M, Mirsky R, Shih H, Minasi P, Boyle A, Grossman W. Cytokine combination therapy with long-acting erythropoietin and granulocyte colony stimulating factor improves cardiac function but is not superior than monotherapy in a mouse model of acute myocardial infarction. J Card Fail. 2010 Aug; 16(8):669-78.

Angeli FS, Amabile N, Burjonroppa S, Shapiro M, Bartlett L, Zhang Y, Virmani R, Chatterjee K, Boyle A, Grossman W, Yeghiazarians Y. Prolonged therapy with erythropoietin is safe and prevents deterioration of left ventricular systolic function in a porcine model of myocardial infarction. J Card Fail. 2010 Jul; 16(7):579-89.

Amabile N, Heiss C, Chang V, Angeli FS, Damon L, Rame EJ, McGlothlin D, Grossman W, De Marco T, Yeghiazarians Y. Increased CD62e(+) endothelial microparticle levels predict poor outcome in pulmonary hypertension patients. J Heart Lung Transplant. 2009 Oct; 28(10):1081-6.

Pons J, Huang Y, Takagawa J, Arakawa-Hoyt J, Ye J, Grossman W, Kan YW, Su H. Combining angiogenic gene and stem cell therapies for myocardial infarction. J Gene Med. 2009 Sep; 11(9):743-53.

Angeli FS, Shapiro M, Amabile N, Orcino G, Smith CS, Tacy T, Boyle AJ, Chatterjee K, Glantz SA, Grossman W, Yeghiazarians Y. Left ventricular remodeling after myocardial infarction: characterization of a swine model on beta-blocker therapy. Comp Med. 2009 Jun; 59(3):272-9.

Michaels AD, Tacy T, Teitel D, Shapiro M, Grossman W. Invasive left ventricular energetics during enhanced external counterpulsation. Am J Ther. 2009 May-Jun; 16(3):239-46.

Yeghiazarians Y, Zhang Y, Prasad M, Shih H, Saini SA, Takagawa J, Sievers RE, Wong ML, Kapasi NK, Mirsky R, Koskenvuo J, Minasi P, Ye J, Viswanathan MN, Angeli FS, Boyle AJ, Springer ML, Grossman W. Injection of bone marrow cell extract into infarcted hearts results in functional improvement comparable to intact cell therapy. Mol Ther. 2009 Jul; 17(7):1250-6.

Pons J, Huang Y, Arakawa-Hoyt J, Washko D, Takagawa J, Ye J, Grossman W, Su H. VEGF improves survival of mesenchymal stem cells in infarcted hearts. Biochem Biophys Res Commun. 2008 Nov 14; 376(2):419-22.

Heiss C, Amabile N, Lee AC, Real WM, Schick SF, Lao D, Wong ML, Jahn S, Angeli FS, Minasi P, Springer ML, Hammond SK, Glantz SA, Grossman W, Balmes JR, Yeghiazarians Y. Brief secondhand smoke exposure depresses endothelial progenitor cells activity and endothelial function: sustained vascular injury and blunted nitric oxide production. J Am Coll Cardiol. 2008 May 06; 51(18):1760-71.

Su H, Takagawa J, Huang Y, Arakawa-Hoyt J, Pons J, Grossman W, Kan YW. Additive effect of AAV-mediated angiopoietin-1 and VEGF expression on the therapy of infarcted heart. Int J Cardiol. 2009 Apr 03; 133(2):191-7.

Amabile N, Heiss C, Real WM, Minasi P, McGlothlin D, Rame EJ, Grossman W, De Marco T, Yeghiazarians Y. Circulating endothelial microparticle levels predict hemodynamic severity of pulmonary hypertension. Am J Respir Crit Care Med. 2008 Jun 01; 177(11):1268-75.

Su H, Yeghiazarians Y, Lee A, Huang Y, Arakawa-Hoyt J, Ye J, Orcino G, Grossman W, Kan YW. AAV serotype 1 mediates more efficient gene transfer to pig myocardium than AAV serotype 2 and plasmid. J Gene Med. 2008 Jan; 10(1):33-41.

Cohen J, Grossman W, Michaels AD. Portable enhanced external counterpulsation for acute coronary syndrome and cardiogenic shock: a pilot study. Clin Cardiol. 2007 May; 30(5):223-8.

Takagawa J, Zhang Y, Wong ML, Sievers RE, Kapasi NK, Wang Y, Yeghiazarians Y, Lee RJ, Grossman W, Springer ML. Myocardial infarct size measurement in the mouse chronic infarction model: comparison of area- and length-based approaches. J Appl Physiol (1985). 2007 Jun; 102(6):2104-11.

Joho S, Ishizaka S, Sievers R, Foster E, Simpson PC, Grossman W. Left ventricular pressure-volume relationship in conscious mice. Am J Physiol Heart Circ Physiol. 2007 Jan; 292(1):H369-77.

Su H, Huang Y, Takagawa J, Barcena A, Arakawa-Hoyt J, Ye J, Grossman W, Kan YW. AAV serotype-1 mediates early onset of gene expression in mouse hearts and results in better therapeutic effect. Gene Ther. 2006 Nov; 13(21):1495-502.

O'Connell TD, Swigart PM, Rodrigo MC, Ishizaka S, Joho S, Turnbull L, Tecott LH, Baker AJ, Foster E, Grossman W, Simpson PC. Alpha1-adrenergic receptors prevent a maladaptive cardiac response to pressure overload. J Clin Invest. 2006 Apr; 116(4):1005-15.

Lin W, Truong N, Grossman WJ, Haribhai D, Williams CB, Wang J, MartĂ­n MG, Chatila TA. Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice. J Allergy Clin Immunol. 2005 Nov; 116(5):1106-15.

Springer ML, Sievers RE, Viswanathan MN, Yee MS, Foster E, Grossman W, Yeghiazarians Y. Closed-chest cell injections into mouse myocardium guided by high-resolution echocardiography. Am J Physiol Heart Circ Physiol. 2005 Sep; 289(3):H1307-14.

McCloskey DT, Turnbull L, Swigart PM, Zambon AC, Turcato S, Joho S, Grossman W, Conklin BR, Simpson PC, Baker AJ. Cardiac transgenesis with the tetracycline transactivator changes myocardial function and gene expression. Physiol Genomics. 2005 Jun 16; 22(1):118-26.

Revell PA, Grossman WJ, Thomas DA, Cao X, Behl R, Ratner JA, Lu ZH, Ley TJ. Granzyme B and the downstream granzymes C and/or F are important for cytotoxic lymphocyte functions. J Immunol. 2005 Feb 15; 174(4):2124-31.

Su H, Joho S, Huang Y, Barcena A, Arakawa-Hoyt J, Grossman W, Kan YW. Adeno-associated viral vector delivers cardiac-specific and hypoxia-inducible VEGF expression in ischemic mouse hearts. Proc Natl Acad Sci U S A. 2004 Nov 16; 101(46):16280-5.

Grossman WJ, Verbsky JW, Tollefsen BL, Kemper C, Atkinson JP, Ley TJ. Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells. Blood. 2004 Nov 01; 104(9):2840-8.

Ishizaka S, Sievers RE, Zhu BQ, Rodrigo MC, Joho S, Foster E, Simpson PC, Grossman W. New technique for measurement of left ventricular pressure in conscious mice. Am J Physiol Heart Circ Physiol. 2004 Mar; 286(3):H1208-15.

O'Connell TD, Ishizaka S, Nakamura A, Swigart PM, Rodrigo MC, Simpson GL, Cotecchia S, Rokosh DG, Grossman W, Foster E, Simpson PC. The alpha(1A/C)- and alpha(1B)-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse. J Clin Invest. 2003 Jun; 111(11):1783-91.

Zhu BQ, Sievers RE, Browne AE, Lee RJ, Chatterjee K, Grossman W, Karliner JS, Parmley WW. Comparative effects of aspirin with ACE inhibitor or angiotensin receptor blocker on myocardial infarction and vascular function. J Renin Angiotensin Aldosterone Syst. 2003 Mar; 4(1):31-7.

Angeja BG, Grossman W. Evaluation and management of diastolic heart failure. Circulation. 2003 Feb 11; 107(5):659-63.

Michaels AD, Accad M, Ports TA, Grossman W. Left ventricular systolic unloading and augmentation of intracoronary pressure and Doppler flow during enhanced external counterpulsation. Circulation. 2002 Sep 03; 106(10):1237-42.

Nakamura A, Rokosh DG, Paccanaro M, Yee RR, Simpson PC, Grossman W, Foster E. LV systolic performance improves with development of hypertrophy after transverse aortic constriction in mice. Am J Physiol Heart Circ Physiol. 2001 Sep; 281(3):H1104-12.

Portis T, Grossman WJ, Harding JC, Hess JL, Ratner L. Analysis of p53 inactivation in a human T-cell leukemia virus type 1 Tax transgenic mouse model. J Virol. 2001 Mar; 75(5):2185-93.

Grossman W. Defining diastolic dysfunction. Circulation. 2000 May 02; 101(17):2020-1.

Lynch JJ, Stump GL, Wallace AA, Painter CA, Thomas JM, Kusma SE, Gould RJ, Grossman W. EXP3174, the AII antagonist human metabolite of losartan, but not losartan nor the angiotensin-converting enzyme inhibitor captopril, prevents the development of lethal ischemic ventricular arrhythmias in a canine model of recent myocardial infarction. J Am Coll Cardiol. 1999 Sep; 34(3):876-84.

Grossman WJ, Verbsky JW, Yang L, Berg LJ, Fields LE, Chaplin DD, Ratner L. Dysregulated myelopoiesis in mice lacking Jak3. Blood. 1999 Aug 01; 94(3):932-9.

Grossman W. The role of sarcoplasmic reticulum proteins in heart disease: introduction. Ann N Y Acad Sci. 1998 Sep 16; 853:207-8.

Shen YT, Wiedmann RT, Greenland BD, Lynch JJ, Grossman W. Combined effects of angiotensin converting enzyme inhibition and angiotensin II receptor antagonism in conscious pigs with congestive heart failure. Cardiovasc Res. 1998 Aug; 39(2):413-22.

Gutstein DE, Flemmal K, Bruce E, Travers KE, Gwathmey JK, Ransil BJ, Markis JE, Grossman W, Morgan JP. Decreased inotropic but relatively preserved relaxation response to cyclic adenosine monophosphate-dependent agents in myopathic human myocardium. J Card Fail. 1996 Dec; 2(4):285-92.

Pitt B, Chang P, Grossman W, Dunlay M, Timmermans PB. Rationale, background, and design of the randomized angiotensin receptor antagonist--angiotensin-converting enzyme inhibitor study (RAAS). Am J Cardiol. 1996 Nov 15; 78(10):1129-31.

Shen YT, Wiedmann RT, Lynch JJ, Grossman W, Johnson RG. GH replacement fails to improve ventricular function in hypophysectomized rats with myocardial infarction. Am J Physiol. 1996 Nov; 271(5 Pt 2):H1721-7.

Sellke FW, Wang SY, Friedman M, Harada K, Edelman ER, Grossman W, Simons M. Basic FGF enhances endothelium-dependent relaxation of the collateral-perfused coronary microcirculation. Am J Physiol. 1994 Oct; 267(4 Pt 2):H1303-11.

Wang J, Flemal K, Qiu Z, Ablin L, Grossman W, Morgan JP. Ca2+ handling and myofibrillar Ca2+ sensitivity in ferret cardiac myocytes with pressure-overload hypertrophy. Am J Physiol. 1994 Sep; 267(3 Pt 2):H918-24.

Harada K, Grossman W, Friedman M, Edelman ER, Prasad PV, Keighley CS, Manning WJ, Sellke FW, Simons M. Basic fibroblast growth factor improves myocardial function in chronically ischemic porcine hearts. J Clin Invest. 1994 Aug; 94(2):623-30.

Watanabe J, Levine MJ, Bellotto F, Johnson RG, Grossman W. Left ventricular diastolic chamber stiffness and intramyocardial coronary capacitance in isolated dog hearts. Circulation. 1993 Dec; 88(6):2929-40.

Pagel PS, Grossman W, Haering JM, Warltier DC. Left ventricular diastolic function in the normal and diseased heart. Perspectives for the anesthesiologist (2). Anesthesiology. 1993 Nov; 79(5):1104-20.

Pagel PS, Grossman W, Haering JM, Warltier DC. Left ventricular diastolic function in the normal and diseased heart. Perspectives for the anesthesiologist (1). Anesthesiology. 1993 Oct; 79(4):836-54.

Litwin SE, Grossman W. Diastolic dysfunction as a cause of heart failure. J Am Coll Cardiol. 1993 Oct; 22(4 Suppl A):49A-55A.

Ho KK, Anderson KM, Kannel WB, Grossman W, Levy D. Survival after the onset of congestive heart failure in Framingham Heart Study subjects. Circulation. 1993 Jul; 88(1):107-15.

Breall JA, Grossman W, Stillman IE, Gianturco LE, Kim D. Atherectomy of the subclavian artery for patients with symptomatic coronary-subclavian steal syndrome. J Am Coll Cardiol. 1993 Jun; 21(7):1564-7.

Breall JA, Watanabe J, Grossman W. Effect of zatebradine on contractility, relaxation and coronary blood flow. J Am Coll Cardiol. 1993 Feb; 21(2):471-7.

Carrozza JP, Bentivegna LA, Williams CP, Kuntz RE, Grossman W, Morgan JP. Decreased myofilament responsiveness in myocardial stunning follows transient calcium overload during ischemia and reperfusion. Circ Res. 1992 Dec; 71(6):1334-40.

Cohen DJ, Kuntz RE, Gordon SP, Piana RN, Safian RD, McKay RG, Baim DS, Grossman W, Diver DJ. Predictors of long-term outcome after percutaneous balloon mitral valvuloplasty. N Engl J Med. 1992 Nov 05; 327(19):1329-35.

Takahashi T, Allen PD, Lacro RV, Marks AR, Dennis AR, Schoen FJ, Grossman W, Marsh JD, Izumo S. Expression of dihydropyridine receptor (Ca2+ channel) and calsequestrin genes in the myocardium of patients with end-stage heart failure. J Clin Invest. 1992 Sep; 90(3):927-35.

Amende I, Bentivegna LA, Zeind AJ, Wenzlaff P, Grossman W, Morgan JP. Intracellular calcium and ventricular function. Effects of nisoldipine on global ischemia in the isovolumic, coronary-perfused heart. J Clin Invest. 1992 Jun; 89(6):2060-5.

Kugelmass AD, Manning WJ, Piana RN, Weintraub RM, Baim DS, Grossman W. Coronary arteriovenous fistula presenting as congestive heart failure. Cathet Cardiovasc Diagn. 1992 May; 26(1):19-25.

Takahashi T, Schunkert H, Isoyama S, Wei JY, Nadal-Ginard B, Grossman W, Izumo S. Age-related differences in the expression of proto-oncogene and contractile protein genes in response to pressure overload in the rat myocardium. J Clin Invest. 1992 Mar; 89(3):939-46.

Hajjar RJ, Grossman W, Gwathmey JK. Responsiveness of the myofilaments to Ca2+ in human heart failure: implications for Ca2+ and force regulation. Basic Res Cardiol. 1992; 87 Suppl 1:143-59.

McKay RG, Penny WF, Wyman RM, Clay W, Carr JG, Bernhard WF, Grossman W. Hemodynamic evaluation of a chronically implanted, electrically powered left ventricular assist system: responses to acute circulatory stress. J Am Coll Cardiol. 1991 Dec; 18(7):1779-86.

Grossman W. Diastolic dysfunction in congestive heart failure. N Engl J Med. 1991 Nov 28; 325(22):1557-64.

Manning WJ, Atkinson DJ, Grossman W, Paulin S, Edelman RR. First-pass nuclear magnetic resonance imaging studies using gadolinium-DTPA in patients with coronary artery disease. J Am Coll Cardiol. 1991 Oct; 18(4):959-65.

Warren SE, Grossman W. Prognosis in heart failure: is systolic or diastolic dysfunction more important? Herz. 1991 Sep; 16 Spec No 1:324-9.

Takahashi T, Levine MJ, Grossman W. Regional diastolic mechanics of ischemic and nonischemic myocardium in the pig heart. J Am Coll Cardiol. 1991 Apr; 17(5):1203-12.

Momomura S, Ferguson JJ, Miller MJ, Parker JA, Grossman W. Regional myocardial blood flow and left ventricular diastolic properties in pacing-induced ischemia. J Am Coll Cardiol. 1991 Mar 01; 17(3):781-9.

Gwathmey JK, Warren SE, Briggs GM, Copelas L, Feldman MD, Phillips PJ, Callahan M, Schoen FJ, Grossman W, Morgan JP. Diastolic dysfunction in hypertrophic cardiomyopathy. Effect on active force generation during systole. J Clin Invest. 1991 Mar; 87(3):1023-31.

Grossman W. Diastolic function and heart failure: an overview. Eur Heart J. 1990 May; 11 Suppl C:2-7.

Morgan JP, Erny RE, Allen PD, Grossman W, Gwathmey JK. Abnormal intracellular calcium handling, a major cause of systolic and diastolic dysfunction in ventricular myocardium from patients with heart failure. Circulation. 1990 Feb; 81(2 Suppl):III21-32.

Grossman W. Diastolic dysfunction and congestive heart failure. Circulation. 1990 Feb; 81(2 Suppl):III1-7.

Levine MJ, Weinstein JS, Diver DJ, Berman AD, Wyman RM, Cunningham MJ, Safian RD, Grossman W, McKay RG. Progressive improvement in pulmonary vascular resistance after percutaneous mitral valvuloplasty. Circulation. 1989 May; 79(5):1061-7.

Hirsch AT, Gervino EV, Nakao S, Come PC, Silverman KJ, Grossman W. The effect of caffeine on exercise tolerance and left ventricular function in patients with coronary artery disease. Ann Intern Med. 1989 Apr 15; 110(8):593-8.

Kihara Y, Gwathmey JK, Grossman W, Morgan JP. Mechanisms of positive inotropic effects and delayed relaxation produced by DPI 201-106 in mammalian working myocardium: effects on intracellular calcium handling. Br J Pharmacol. 1989 Apr; 96(4):927-39.

Wei JY, Li Y, Lincoln T, Grossman W, Mendelowitz D. Chronic exercise training protects aged cardiac muscle against hypoxia. J Clin Invest. 1989 Mar; 83(3):778-84.

Ferguson JJ, Miller MJ, Aroesty JM, Sahagian P, Grossman W, McKay RG. Assessment of right atrial pressure-volume relations in patients with and without an atrial septal defect. J Am Coll Cardiol. 1989 Mar 01; 13(3):630-6.

Wyman RM, Farhi ER, Bing OH, Johnson RG, Weintraub RM, Grossman W. Comparative effects of hypoxia and ischemia in the isolated, blood-perfused dog heart: evaluation of left ventricular diastolic chamber distensibility and wall thickness. Circ Res. 1989 Jan; 64(1):121-8.

Safian RD, Warren SE, Berman AD, Diver DJ, McKay LL, Come PC, Grossman W, McKay RG. Improvement in symptoms and left ventricular performance after balloon aortic valvuloplasty in patients with aortic stenosis and depressed left ventricular ejection fraction. Circulation. 1988 Nov; 78(5 Pt 1):1181-91.

Feldman MD, Alderman JD, Aroesty JM, Royal HD, Ferguson JJ, Owen RM, Grossman W, McKay RG. Depression of systolic and diastolic myocardial reserve during atrial pacing tachycardia in patients with dilated cardiomyopathy. J Clin Invest. 1988 Nov; 82(5):1661-9.

Berman AD, Weinstein JS, Safian RD, Diver DJ, Grossman W, McKay RG. Combined aortic and mitral balloon valvuloplasty in patients with critical aortic and mitral valve stenosis: results in six cases. J Am Coll Cardiol. 1988 Jun; 11(6):1213-8.

Isoyama S, Grossman W, Wei JY. Effect of age on myocardial adaptation to volume overload in the rat. J Clin Invest. 1988 Jun; 81(6):1850-7.

Warren SE, Royal HD, Markis JE, Grossman W, McKay RG. Time course of left ventricular dilation after myocardial infarction: influence of infarct-related artery and success of coronary thrombolysis. J Am Coll Cardiol. 1988 Jan; 11(1):12-9.

McKay RG, Safian RD, Berman AD, Diver DJ, Weinstein JS, Wyman RM, Cunningham MJ, McKay LL, Baim DS, Grossman W. Combined percutaneous aortic valvuloplasty and transluminal coronary angioplasty in adult patients with calcific aortic stenosis and coronary artery disease. Circulation. 1987 Dec; 76(6):1298-306.

Gwathmey JK, Copelas L, MacKinnon R, Schoen FJ, Feldman MD, Grossman W, Morgan JP. Abnormal intracellular calcium handling in myocardium from patients with end-stage heart failure. Circ Res. 1987 Jul; 61(1):70-6.

Lorell BH, Grossman W. Cardiac hypertrophy: the consequences for diastole. J Am Coll Cardiol. 1987 May; 9(5):1189-93.

Safian RD, Mandell VS, Thurer RE, Hutchins GM, Schnitt SJ, Grossman W, McKay RG. Postmortem and intraoperative balloon valvuloplasty of calcific aortic stenosis in elderly patients: mechanisms of successful dilation. J Am Coll Cardiol. 1987 Mar; 9(3):655-60.

McKay RG, Miller MJ, Ferguson JJ, Momomura S, Sahagian P, Grossman W, Pasternak RC. Assessment of left ventricular end-systolic pressure-volume relations with an impedance catheter and transient inferior vena cava occlusion: use of this system in the evaluation of the cardiotonic effects of dobutamine, milrinone, Posicor and epinephrine. J Am Coll Cardiol. 1986 Nov; 8(5):1152-60.

McKay RG, Pfeffer MA, Pasternak RC, Markis JE, Come PC, Nakao S, Alderman JD, Ferguson JJ, Safian RD, Grossman W. Left ventricular remodeling after myocardial infarction: a corollary to infarct expansion. Circulation. 1986 Oct; 74(4):693-702.

Bourdillon PD, Paulus WJ, Serizawa T, Grossman W. Effects of verapamil on regional myocardial diastolic function in pacing-induced ischemia in dogs. Am J Physiol. 1986 Oct; 251(4 Pt 2):H834-40.

Li Y, Lincoln T, Mendelowitz D, Grossman W, Wei JY. Age-related differences in effect of exercise training on cardiac muscle function in rats. Am J Physiol. 1986 Jul; 251(1 Pt 2):H12-8.

McKay RG, Aroesty JM, Heller GV, Royal HD, Warren SE, Grossman W. Assessment of the end-systolic pressure-volume relationship in human beings with the use of a time-varying elastance model. Circulation. 1986 Jul; 74(1):97-104.

McKay RG, Lock JE, Keane JF, Safian RD, Aroesty JM, Grossman W. Percutaneous mitral valvuloplasty in an adult patient with calcific rheumatic mitral stenosis. J Am Coll Cardiol. 1986 Jun; 7(6):1410-5.

Miller MJ, McKay RG, Ferguson JJ, Sahagian P, Nakao S, Come PC, Grossman W. Right atrial pressure-volume relationships in tricuspid regurgitation. Circulation. 1986 Apr; 73(4):799-808.

Monrad ES, Baim DS, Smith HS, Lanoue AS, Silverman KJ, Gervino EV, Grossman W. Assessment of long-term therapy with milrinone and the effects of milrinone withdrawal. Circulation. 1986 Mar; 73(3 Pt 2):III205-12.

Baim DS, Colucci WS, Monrad ES, Smith HS, Wright RF, Lanoue A, Gauthier DF, Ransil BJ, Grossman W, Braunwald E. Survival of patients with severe congestive heart failure treated with oral milrinone. J Am Coll Cardiol. 1986 Mar; 7(3):661-70.

Nakao S, Come PC, Miller MJ, Momomura S, Sahagian P, Ransil BJ, Grossman W. Effects of supine and lateral positions on cardiac output and intracardiac pressures: an experimental study. Circulation. 1986 Mar; 73(3):579-85.

Grossman W. Assessment of regional myocardial function. J Am Coll Cardiol. 1986 Feb; 7(2):327-8.

Bourdillon PD, Bettmann MA, McCracken S, Poole-Wilson PA, Grossman W. Effects of a new nonionic and a conventional ionic contrast agent on coronary sinus ionized calcium and left ventricular hemodynamics in dogs. J Am Coll Cardiol. 1985 Oct; 6(4):845-53.

Monrad ES, Baim DS, Smith HS, Lanoue A, Brauwald E, Grossman W. Effects of milrinone on coronary hemodynamics and myocardial energetics in patients with congestive heart failure. Circulation. 1985 May; 71(5):972-9.

Aroesty JM, McKay RG, Heller GV, Royal HD, Als AV, Grossman W. Simultaneous assessment of left ventricular systolic and diastolic dysfunction during pacing-induced ischemia. Circulation. 1985 May; 71(5):889-900.

Paulus WJ, Grossman W, Serizawa T, Bourdillon PD, Pasipoularides A, Mirsky I. Different effects of two types of ischemia on myocardial systolic and diastolic function. Am J Physiol. 1985 May; 248(5 Pt 2):H719-28.

Borow KM, Come PC, Neumann A, Baim DS, Braunwald E, Grossman W. Physiologic assessment of the inotropic, vasodilator and afterload reducing effects of milrinone in subjects without cardiac disease. Am J Cardiol. 1985 Apr 15; 55(9):1204-9.

Monrad ES, McKay RG, Baim DS, Colucci WS, Fifer MA, Heller GV, Royal HD, Grossman W. Improvement in indexes of diastolic performance in patients with congestive heart failure treated with milrinone. Circulation. 1984 Dec; 70(6):1030-7.

Momomura S, Bradley AB, Grossman W. Left ventricular diastolic pressure-segment length relations and end-diastolic distensibility in dogs with coronary stenoses. An angina physiology model. Circ Res. 1984 Aug; 55(2):203-14.

McKay RG, Aroesty JM, Heller GV, Silverman KJ, Parker JA, Als AV, Come PC, Kolodny GM, Grossman W. The pacing stress test reexamined: correlation of pacing-induced hemodynamic changes with the amount of myocardium at risk. J Am Coll Cardiol. 1984 Jun; 3(6):1469-81.

Heller GV, Aroesty JM, Parker JA, McKay RG, Silverman KJ, Als AV, Come PC, Kolodny GM, Grossman W. The pacing stress test: thallium-201 myocardial imaging after atrial pacing. Diagnostic value in detecting coronary artery disease compared with exercise testing. J Am Coll Cardiol. 1984 May; 3(5):1197-204.

McKay RG, Spears JR, Aroesty JM, Baim DS, Royal HD, Heller GV, Lincoln W, Salo RW, Braunwald E, Grossman W. Instantaneous measurement of left and right ventricular stroke volume and pressure-volume relationships with an impedance catheter. Circulation. 1984 Apr; 69(4):703-10.

McKay RG, Aroesty JM, Heller GV, Royal H, Parker JA, Silverman KJ, Kolodny GM, Grossman W. Left ventricular pressure-volume diagrams and end-systolic pressure-volume relations in human beings. J Am Coll Cardiol. 1984 Feb; 3(2 Pt 1):301-12.

Paulus WJ, Lorell BH, Craig WE, Wynne J, Murgo JP, Grossman W. Comparison of the effects of nitroprusside and nifedipine on diastolic properties in patients with hypertrophic cardiomyopathy: altered left ventricular loading or improved muscle inactivation? J Am Coll Cardiol. 1983 Nov; 2(5):879-86.

Dervan JP, Baim DS, Cherniles J, Grossman W. Transluminal angioplasty of occluded coronary arteries: use of a movable guide wire system. Circulation. 1983 Oct; 68(4):776-84.

Kern MJ, Ganz P, Horowitz JD, Gaspar J, Barry WH, Lorell BH, Grossman W, Mudge GH. Potentiation of coronary vasoconstriction by beta-adrenergic blockade in patients with coronary artery disease. Circulation. 1983 Jun; 67(6):1178-85.

Spears JR, Marais HJ, Serur J, Pomerantzeff O, Geyer RP, Sipzener RS, Weintraub R, Thurer R, Paulin S, Gerstin R, Grossman W. In vivo coronary angioscopy. J Am Coll Cardiol. 1983 May; 1(5):1311-4.

Konstam MA, Idoine J, Wynne J, Grossman W, Cohn L, Beck JR, Kozlowski J, Holman BL. Right ventricular function in adults with pulmonary hypertension with and without atrial septal defect. Am J Cardiol. 1983 Apr; 51(7):1144-8.

Bourdillon PD, Lorell BH, Mirsky I, Paulus WJ, Wynne J, Grossman W. Increased regional myocardial stiffness of the left ventricle during pacing-induced angina in man. Circulation. 1983 Feb; 67(2):316-23.

Borow KM, Green LH, Grossman W, Braunwald E. Left ventricular end-systolic stress-shortening and stress-length relations in human. Normal values and sensitivity to inotropic state. Am J Cardiol. 1982 Dec; 50(6):1301-8.

Lorell BH, Paulus WJ, Grossman W, Wynne J, Cohn PF. Modification of abnormal left ventricular diastolic properties by nifedipine in patients with hypertrophic cardiomyopathy. Circulation. 1982 Mar; 65(3):499-507.

Paulus WJ, Serizawa T, Grossman W. Altered left ventricular diastolic properties during pacing-induced ischemia in dogs with coronary stenoses. Potentiation by caffeine. Circ Res. 1982 Feb; 50(2):218-27.

Friedman PL, Brown EJ, Gunther S, Alexander RW, Barry WH, Mudge GH, Grossman W. Coronary vasoconstrictor effect of indomethacin in patients with coronary-artery disease. N Engl J Med. 1981 Nov 12; 305(20):1171-5.

Markis JE, Malagold M, Parker JA, Silverman KJ, Barry WH, Als AV, Paulin S, Grossman W, Braunwald E. Myocardial salvage after intracoronary thrombolysis with streptokinase in acute myocardial infarction. N Engl J Med. 1981 Oct 01; 305(14):777-82.

Rude RE, Turi Z, Brown EJ, Lorell BH, Colucci WS, Mudge GH, Taylor CR, Grossman W. Acute effects of oral pirbuterol on myocardial oxygen metabolism and systemic hemodynamics in chronic congestive heart failure. Circulation. 1981 Jul; 64(1):139-45.

Serizawa T, Vogel WM, Apstein CS, Grossman W. Comparison of acute alterations in left ventricular relaxation and diastolic chamber stiffness induced by hypoxia and ischemia. Role of myocardial oxygen supply-demand imbalance. J Clin Invest. 1981 Jul; 68(1):91-102.

Gunther S, Green L, Muller JE, Mudge GH, Grossman W. Prevention of nifedipine of abnormal coronary vasoconstriction in patients with coronary artery disease. Circulation. 1981 Apr; 63(4):849-55.

Lorell BH, Paulus WJ, Grossman W, Wynne J, Cohn PF, Braunwald E. Improved diastolic function and systolic performance in hypertrophic cardiomyopathy after nifedipine. N Engl J Med. 1980 Oct 02; 303(14):801-3.

Carabello BA, Green LH, Grossman W, Cohn LH, Koster JK, Collins JJ. Hemodynamic determinants of prognosis of aortic valve replacement in critical aortic stenosis and advanced congestive heart failure. Circulation. 1980 Jul; 62(1):42-8.

Benotti JR, Grossman W, Braunwald E, Carabello BA. Effects of amrinone on myocardial energy metabolism and hemodynamics in patients with severe congestive heart failure due to coronary artery disease. Circulation. 1980 Jul; 62(1):28-34.

Borow KM, Green LH, Mann T, Sloss LJ, Braunwald E, Collins JJ, Cohn L, Grossman W. End-systolic volume as a predictor of postoperative left ventricular performance in volume overload from valvular regurgitation. Am J Med. 1980 May; 68(5):655-63.

Wynne J, Mann T, Alpert JS, Green LH, Grossman W. Hemodynamic effects of nitrous oxide administered during cardiac catheterization. JAMA. 1980 Apr 11; 243(14):1440-2.

Serizawa T, Carabello BA, Grossman W. Effect of pacing-induced ischemia on left ventricular diastolic pressure-volume relations in dogs with coronary stenoses. Circ Res. 1980 Mar; 46(3):430-9.

Grossman W, Barry WH. Diastolic pressure-volume relations in the diseased heart. Fed Proc. 1980 Feb; 39(2):148-55.

Alpert JS, Sloss LJ, Cohn PF, Grossman W. The diagnostic accuracy of combined clinical and noninvasive cardiac evaluation: comparison with findings at cardiac catheterization. Cathet Cardiovasc Diagn. 1980; 6(4):359-70.

Grossman W, Serizawa T, Carabello BA. Studies on the mechanism of altered left ventricular diastolic pressure-volume relations during ischaemia. Eur Heart J. 1980; Suppl A:141-7.

Marsh JD, Green LH, Wynne J, Cohn PF, Grossman W. Left ventricular end-systolic pressure-dimension and stress-length relations in normal human subjects. Am J Cardiol. 1979 Dec; 44(7):1311-7.

Gunther S, Green L, Muller JE, Mudge GH, Grossman W. Inappropriate coronary vasoconstriction in patients with coronary artery disease: a role for nifedipine? Am J Cardiol. 1979 Oct 22; 44(5):793-7.

Carabello BA, Barry WH, Grossman W. Changes in arterial pressure during left heart pullback in patients with aortic stenosis: a sign of severe aortic stenosis. Am J Cardiol. 1979 Sep; 44(3):424-7.

Gunther S, Grossman W. Determinants of ventricular function in pressure-overload hypertrophy in man. Circulation. 1979 Apr; 59(4):679-88.

Mann T, Goldberg S, Mudge GH, Grossman W. Factors contributing to altered left ventricular diastolic properties during angina pectoris. Circulation. 1979 Jan; 59(1):14-20.

Goldberg S, Mann T, Grossman W. Nitrate therapy of heart failure in valvular heart disease. Importance of resting level of peripheral vascular resistance in determining cardiac output response. Am J Med. 1978 Jul; 65(1):161-6.

Goldberg S, Grossman W, Markis JE, Cohen MV, Baltaxe HA, Levin DC. Total occlusion of the left main coronary artery. A clinical, hemodynamic and angiographic profile. Am J Med. 1978 Jan; 64(1):3-8.

Grossman W, Braunwald E, Mann T, McLaurin LP, Green LH. Contractile state of the left ventricle in man as evaluated from end-systolic pressure-volume relations. Circulation. 1977 Nov; 56(5):845-52.

Mann T, Brodie BR, Grossman W, McLaurin LP. Effect of angina on the left ventricular diastolic pressure-volume relationship. Circulation. 1977 May; 55(5):761-6.

Brodie BR, Grossman W, Mann T, McLaurin LP. Effects of sodium nitroprusside on left ventricular diastolic pressure-volume relations. J Clin Invest. 1977 Jan; 59(1):59-68.

Mudge GH, Grossman W, Mills RM, Lesch M, Braunwald E. Reflex increase in coronary vascular resistance in patients with ischemic heart disease. N Engl J Med. 1976 Dec 09; 295(24):1333-7.

Brodie BR, Cuck L, Klausner S, Grossman W, Parmley W. Effects of sodium nitroprusside and nitroglycerin on tension prolongation of cat papillary muscle during recovery from hypoxia. Circ Res. 1976 Oct; 39(4):596-601.

Mudge GH, Grossman W, Mills RM, Lesch M, Braunwald E. Evidence for reflex coronary artery spasm in patients with ischemic heart disease. Trans Assoc Am Physicians. 1976; 89:225-36.

Brodie BR, Grossman W, McLaurin L, Starek PJ, Craige E. Diagnosis of prosthetic mitral valve malfunction with combined echo-phonocardiography. Circulation. 1976 Jan; 53(1):93-100.

Mann T, McLaurin L, Grossman W, Craige E. Assessing the hemodynamic severity of acute aortic regurgitation due to infective endocarditis. N Engl J Med. 1975 Jul 17; 293(3):108-13.

Grossman W, Jones D, McLaurin LP. Wall stress and patterns of hypertrophy in the human left ventricle. J Clin Invest. 1975 Jul; 56(1):56-64.

Rankin LS, Moos S, Grossman W. Alterations in preload and ejection phase indices of left ventricular performance,. Circulation. 1975 May; 51(5):910-15.

Grossman W, McLaurin LP, Stefadouros MA. Left ventricular stiffness associated with chronic pressure and volume overloads in man. Circ Res. 1974 Nov; 35(5):793-800.

Stefadouros MA, Grossman W, el-Shahawy M, Witham C. The effect of isometric exercise on the left ventricular volume in normal man. Circulation. 1974 Jun; 49(6):1185-9.

Grossman W, McLaurin LP, Moos SP, Stefadouros M, Young DT. Wall thickness and diastolic properties of the left ventricle. Circulation. 1974 Jan; 49(1):129-35.

McLaurin LP, Rolett EL, Grossman W. Impaired left ventricular relaxation during pacing-induced ischemia. Am J Cardiol. 1973 Nov; 32(6):751-7.

McLaurin LP, Gibson TC, Waider W, Grossman W, Craige E. An appraisal of mitral valve echocardiograms mimicking mitral stenosis in conditions with right ventricular pressure overload. Circulation. 1973 Oct; 48(4):801-9.

McLaurin LP, Grossman W, Stefadouros MA, Rolett EL, Young DT. A new technique for the study of left ventricular pressure-volume relations in man. Circulation. 1973 Jul; 48(1):56-64.

Grossman W, McLaurin LP, Saltz SB, Paraskos JA, Dalen JE, Dexter L. Changes in the inotropic state of the left ventricle during isometric exercise. Br Heart J. 1973 Jul; 35(7):697-704.

Grossman W, Stefadouros MA, McLaurin LP, Rolett EL, Young DT. Quantitative assessment of left ventricular diastolic stiffness in man. Circulation. 1973 Mar; 47(3):567-74.

Johnson LW, Grossman W, Dalen JE, Dexter L. Pulmonic stenosis in the adult. Long-term follow-up results. N Engl J Med. 1972 Dec 07; 287(23):1159-63.

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