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UCSF Cardiology
Transforming medicine through innovation and collaboration.
Department of Medicine

Faculty Profiles

Liviu Klein, MD, MS
M_MED-CARD-CORE
Associate Professor

505 Parnassus Avenue
San Francisco, CA 94117
415-502-8584
Liviu.Klein@ucsf.edu

CLINICAL INTERESTS
My clinical interests are heart failure and cardiac arrhythmias in patients with heart failure. Having advanced training in both heart failure and electrophysiology, I practice an integrated approach in treating patients with heart failure and cardiac arrhythmias. I am also interested in cardiac recovery using electrical (i.e. cardiac resynchronization) and mechanical (i.e. ventricular assist devices) therapies. I treat patients across the heart failure spectrum, from early diagnosis to heart transplantation.


RESEARCH INTERESTS
My research is aimed at understanding the epidemiology of heart failure in women and sudden cardiac death in women with heart failure. In addition, I am developing new diagnostic sensors and therapeutic devices for patients with cardiovascular disease, including patients with heart failure.

Education and Training

Location Degree or Training Specialty Date
Northwestern Memorial Hospital Fellow Clinical Cardiac Electrophysiology 2009
Northwestern Memorial Hospital Fellow Advanced Heart Failure and Transplantation 2008
Northwestern Memorial Hospital Fellow Cardiovascular Disease 2007
Northwestern University MSCI Graduate School 2005
Northwestern University Fellow Cardiovascular Epidemiology 2005
Advocate Illinois Masonic Medical Center Resident Internal Medicine 2003
University Hospital Bucharest Resident Internal Medicine 2000
Carol Davila School of Medicine MD Medicine 1999

Interests

Cardiac resynchronization therapy, Extracorporeal life support, Heart transplantation, Implantable cardioverter defibrillators, Implantable hemodynamics monitors, Sudden death, Ventricular assist devices, Wearable sensors

Awards and Honors
2016   Sezai Innovative Research Award, International Society for Rotary Blood Pumps, 2016
2013   Cardiology Faculty Teaching Award, University of California San Francisco, 2013
2009   Larry Jameson Research Award, Northwestern University Feinberg School of Medicine, 2009
2003   Outstanding Senior Resident Award, Advocate Illinois Masonic Medical Center, 2003

Related Web Sites

In the News

Awarded Grants

Project Title Project Number Fiscal Year
WHISH-2-Prevent Heart Failure Study R01HL130591 2021
Non-invasive biosensors to detect cardiovascular changes in heart failure R01HL130619 2021
CorBand: A novel wearable wrist sensor for heart failure remote monitoring R44HL125001 2018
Wearable Cardiomechanics Monitor to Decrease Heart Failure Readmissions R56AG048458 2016
Heart Failure Evaluation in Post-Menopausal Women: The Women's Health Initiative R21AG027471 2010
Recent Articles (52)

Klein L. (Re)Discovering the Neurohormonal and Hemodynamic Duality of Heart Failure. J Am Coll Cardiol. 2017 Oct 10; 70(15):1887-1889.

Hall PS, Nah G, Howard BV, Lewis CE, Allison MA, Sarto GE, Waring ME, Jacobson LT, Manson JE, Klein L, Parikh NI. Reproductive Factors and Incidence of Heart Failure Hospitalization in the Women's Health Initiative. J Am Coll Cardiol. 2017 May 23; 69(20):2517-2526.

Pandey A, LaMonte M, Klein L, Ayers C, Psaty BM, Eaton CB, Allen NB, de Lemos JA, Carnethon M, Greenland P, Berry JD. Relationship Between Physical Activity, Body Mass Index, and Risk of Heart Failure. J Am Coll Cardiol. 2017 Mar 07; 69(9):1129-1142.

Brondfield MN, Reid MJ, Rutishauser RL, Cope JR, Tang J, Ritter JM, Matanock A, Ali I, Doernberg SB, Hilts-Horeczko A, DeMarco T, Klein L, Babik JM. Disseminated Acanthamoeba infection in a heart transplant recipient treated successfully with a miltefosine-containing regimen: Case report and review of the literature. Transpl Infect Dis. 2017 Apr; 19(2).

Cowie MR, Simon M, Klein L, Thokala P. The cost-effectiveness of real-time pulmonary artery pressure monitoring in heart failure patients: a European perspective. Eur J Heart Fail. 2017 May; 19(5):661-669.

Eaton CB, Pettinger M, Rossouw J, Martin LW, Foraker R, Quddus A, Liu S, Wampler NS, Hank Wu WC, Manson JE, Margolis K, Johnson KC, Allison M, Corbie-Smith G, Rosamond W, Breathett K, Klein L. Risk Factors for Incident Hospitalized Heart Failure With Preserved Versus Reduced Ejection Fraction in a Multiracial Cohort of Postmenopausal Women. Circ Heart Fail. 2016 Oct; 9(10).

Sack KL, Baillargeon B, Acevedo-Bolton G, Genet M, Rebelo N, Kuhl E, Klein L, Weiselthaler GM, Burkhoff D, Franz T, Guccione JM. Partial LVAD restores ventricular outputs and normalizes LV but not RV stress distributions in the acutely failing heart in silico. Int J Artif Organs. 2016 Oct 10; 39(8):421-430.

Klein L. Treating Hemodynamic Congestion Is the Key to Prevent Heart Failure Hospitalizations. JACC Heart Fail. 2016 May; 4(5):345-7.

Klein L, Greenberg BH, Konstam MA, Gregory D, Kociol RD, Johnson MR, de Marco T. Activities and Compensation of Advanced Heart Failure Specialists: Results of the Heart Failure Society of America (HFSA) Survey. J Card Fail. 2015 Nov; 21(11):924-9.

Rogers SE, Klein L, Perissinotto CM. The importance of cognitive assessment before ventricular device placement: a teachable moment. JAMA Intern Med. 2015 Jun; 175(6):890.

Etemadi M, Inan OT, Heller JA, Hersek S, Klein L, Roy S. A Wearable Patch to Enable Long-Term Monitoring of Environmental, Activity and Hemodynamics Variables. IEEE Trans Biomed Circuits Syst. 2016 Apr; 10(2):280-8.

Donneyong MM, Hornung CA, Taylor KC, Baumgartner RN, Myers JA, Eaton CB, Gorodeski EZ, Klein L, Martin LW, Shikany JM, Song Y, Li W, Manson JE. Risk of heart failure among postmenopausal women: a secondary analysis of the randomized trial of vitamin D plus calcium of the women's health initiative. Circ Heart Fail. 2015 Jan; 8(1):49-56.

Wiens AD, Etemadi M, Roy S, Klein L, Inan OT. Toward continuous, noninvasive assessment of ventricular function and hemodynamics: wearable ballistocardiography. IEEE J Biomed Health Inform. 2015 Jul; 19(4):1435-42.

Klein L, Hsia H. Sudden cardiac death in heart failure. Cardiol Clin. 2014 Feb; 32(1):135-44, ix.

Etemadi M, Hersek S, Tseng JM, Rabbani N, Heller JA, Roy S, Klein L, Inan OT. Tracking clinical status for heart failure patients using ballistocardiography and electrocardiography signal features. Conf Proc IEEE Eng Med Biol Soc. 2014; 2014:5188-91.

Wiens A, Etemadi M, Klein L, Roy S, Inan OT. Wearable ballistocardiography: preliminary methods for mapping surface vibration measurements to whole body forces. Conf Proc IEEE Eng Med Biol Soc. 2014; 2014:5172-5.

Sridharan L, Klein L. Prognostic factors in patients hospitalized for heart failure. Curr Heart Fail Rep. 2013 Dec; 10(4):380-6.

Perez MV, Wang PJ, Larson JC, Soliman EZ, Limacher M, Rodriguez B, Klein L, Manson JE, Martin LW, Prineas R, Connelly S, Hlatky M, Wassertheil-Smoller S, Stefanick ML. Risk factors for atrial fibrillation and their population burden in postmenopausal women: the Women's Health Initiative Observational Study. Heart. 2013 Aug; 99(16):1173-8.

Perez MV, Wang PJ, Larson JC, Virnig BA, Cochrane B, Curb JD, Klein L, Manson JE, Martin LW, Robinson J, Wassertheil-Smoller S, Stefanick ML. Effects of postmenopausal hormone therapy on incident atrial fibrillation: the Women's Health Initiative randomized controlled trials. Circ Arrhythm Electrophysiol. 2012 Dec; 5(6):1108-16.

Klein L. ACP Journal Club. Review: new oral anticoagulants reduced stroke and systemic embolism compared with warfarin in AF. Ann Intern Med. 2012 Sep 18; 157(6):JC3-2.

Avery CL, Sethupathy P, Buyske S, He Q, Lin DY, Arking DE, Carty CL, Duggan D, Fesinmeyer MD, Hindorff LA, Jeff JM, Klein L, Patton KK, Peters U, Shohet RV, Sotoodehnia N, Young AM, Kooperberg C, Haiman CA, Mohlke KL, Whitsel EA, North KE. Fine-mapping and initial characterization of QT interval loci in African Americans. PLoS Genet. 2012; 8(8):e1002870.

Eaton CB, Abdulbaki AM, Margolis KL, Manson JE, Limacher M, Klein L, Allison MA, Robinson JG, Curb JD, Martin LA, Liu S, Howard BV. Racial and ethnic differences in incident hospitalized heart failure in postmenopausal women: the Women's Health Initiative. Circulation. 2012 Aug 07; 126(6):688-96.

Klein L. Rivaroxaban reduced stroke and systemic embolism compared with warfarin in nonvalvular AF. Ann Intern Med. 2012 Jan 17; 156(2):JC1-2, JC1-3.

Klein L. Apixaban reduced stroke and systemic embolism compared with warfarin in atrial fibrillation. Ann Intern Med. 2012 Jan 17; 156(2):JC1-2, JC1-3.

Shah RU, Winkleby MA, Van Horn L, Phillips LS, Eaton CB, Martin LW, Rosal MC, Manson JE, Ning H, Lloyd-Jones DM, Klein L. Education, income, and incident heart failure in post-menopausal women: the Women's Health Initiative Hormone Therapy Trials. J Am Coll Cardiol. 2011 Sep 27; 58(14):1457-64.

Klein L, Grau-Sepulveda MV, Bonow RO, Hernandez AF, Williams MV, Bhatt DL, Fonarow GC. Quality of care and outcomes in women hospitalized for heart failure. Circ Heart Fail. 2011 Sep; 4(5):589-98.

Klein L. Omnes viae Romam ducunt: Asymptomatic cardiac and noncardiac organ system dysfunction leads to heart failure. Circulation. 2011 Jul 05; 124(1):4-6.

Tempelhof MW, Klein L, Cotts WG, Benzuly KH, Davidson CJ, Meyers SN, McCarthy PM, Malaisrie CS, McGee EC, Beohar N. Clinical experience and patient outcomes associated with the TandemHeart percutaneous transseptal assist device among a heterogeneous patient population. ASAIO J. 2011 Jul-Aug; 57(4):254-61.

Svetlichnaya J, Klein L. Atrial fibrillation in elderly patients with heart failure: convergence of two cardiovascular epidemics in the 21st Century. Expert Rev Cardiovasc Ther. 2011 Jul; 9(7):903-12.

Shah RU, Tsai V, Klein L, Heidenreich PA. Characteristics and outcomes of very elderly patients after first hospitalization for heart failure. Circ Heart Fail. 2011 May; 4(3):301-7.

Klein L. ACP Journal Club. Higher-dose dabigatran reduced stroke, but not major hemorrhage, more than warfarin in atrial fibrillation. Ann Intern Med. 2010 Jan 19; 152(2):JC1-2.

Shah RU, Klein L, Lloyd-Jones DM. Heart failure in women: epidemiology, biology and treatment. Womens Health (Lond). 2009 Sep; 5(5):517-27.

Klein L, Massie BM, Leimberger JD, O'Connor CM, Piña IL, Adams KF, Califf RM, Gheorghiade M. Admission or changes in renal function during hospitalization for worsening heart failure predict postdischarge survival: results from the Outcomes of a Prospective Trial of Intravenous Milrinone for Exacerbations of Chronic Heart Failure (OPTIME-CHF). Circ Heart Fail. 2008 May; 1(1):25-33.

Klein L, O'connell JB. Thromboembolic risk in the patient with heart failure. Curr Treat Options Cardiovasc Med. 2007 Aug; 9(4):310-7.

Lloyd-Jones DM, Liu K, Colangelo LA, Yan LL, Klein L, Loria CM, Lewis CE, Savage P. Consistently stable or decreased body mass index in young adulthood and longitudinal changes in metabolic syndrome components: the Coronary Artery Risk Development in Young Adults Study. Circulation. 2007 Feb 27; 115(8):1004-11.

Gheorghiade M, Zannad F, Sopko G, Klein L, Piña IL, Konstam MA, Massie BM, Roland E, Targum S, Collins SP, Filippatos G, Tavazzi L. Acute heart failure syndromes: current state and framework for future research. Circulation. 2005 Dec 20; 112(25):3958-68.

De Luca L, Klein L, Udelson JE, Orlandi C, Sardella G, Fedele F, Gheorghiade M. Hyponatremia in patients with heart failure. Am J Cardiol. 2005 Dec 19; 96(12A):19L-23L.

Klein L, O'Connor CM, Leimberger JD, Gattis-Stough W, Piña IL, Felker GM, Adams KF, Califf RM, Gheorghiade M. Lower serum sodium is associated with increased short-term mortality in hospitalized patients with worsening heart failure: results from the Outcomes of a Prospective Trial of Intravenous Milrinone for Exacerbations of Chronic Heart Failure (OPTIME-CHF) study. Circulation. 2005 May 17; 111(19):2454-60.

Klein L. Posting treatment recommendations to primary care physicians does not improve care for people with myocardial infarction or heart failure. Commentary. Evid Based Cardiovasc Med. 2005 Mar; 9(1):72-5.

Klein L, Gheorghiade M. Coronary artery disease and prevention of heart failure. Med Clin North Am. 2004 Sep; 88(5):1209-35.

Danciu SC, Klein L, Hosseini MM, Ibrahim L, Coyle BW, Kehoe RF. A predictive model for survival after in-hospital cardiopulmonary arrest. Resuscitation. 2004 Jul; 62(1):35-42.

Klein L, Galvez A, Klein O, Chediak J. Warfarin-induced limb gangrene in the setting of lung adenocarcinoma. Am J Hematol. 2004 Jun; 76(2):176-9.

Klein L, Gattis WA, Borrello F, Wu E, O'Connor CM, Gheorghiade M. Effects of amino acid supplementation on left ventricular remodeling in patients with chronic heart failure with decreased systolic function and diabetes mellitus: rationale and design of a magnetic resonance imaging study. Am J Cardiol. 2004 Apr 22; 93(8A):44A-46A.

Piccini JP, Klein L, Gheorghiade M, Bonow RO. New insights into diastolic heart failure: role of diabetes mellitus. Am J Med. 2004 Mar 08; 116 Suppl 5A:64S-75S.

Klein L, Gheorghiade M. Management of the patient with diabetes mellitus and myocardial infarction: clinical trials update. Am J Med. 2004 Mar 08; 116 Suppl 5A:47S-63S.

Gheorghiade M, Klein L, Stone NJ, Bonow RO, Kim RJ. Improvement in the function of hibernating myocardium in a patient with heart failure due to coronary artery disease receiving high-dose simvastatin. Ital Heart J. 2004 Feb; 5(2):160-2.

Klein L, O'Connor CM, Gattis WA, Zampino M, de Luca L, Vitarelli A, Fedele F, Gheorghiade M. Pharmacologic therapy for patients with chronic heart failure and reduced systolic function: review of trials and practical considerations. Am J Cardiol. 2003 May 08; 91(9A):18F-40F.

Jain P, Massie BM, Gattis WA, Klein L, Gheorghiade M. Current medical treatment for the exacerbation of chronic heart failure resulting in hospitalization. Am Heart J. 2003 Feb; 145(2 Suppl):S3-17.

Klein L, Gheorghiade M. Therapeutic strategies for patients hospitalized with worsening heart failure. Ital Heart J. 2003 Feb; 4(2):71-4.

Gheorghiade M, Gattis WA, Klein L. OPTIME in CHF trial: rethinking the use of inotropes in the management of worsening chronic heart failure resulting in hospitalization. Eur J Heart Fail. 2003 Jan; 5(1):9-12.

Borrello F, Beahan M, Klein L, Gheorghiade M. Reappraisal of beta-blocker therapy in the acute and chronic post-myocardial infarction period. Rev Cardiovasc Med. 2003; 4 Suppl 3:S13-24.

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