Faculty ProfilesRima Arnaout, MD
555 Mission Bay Blvd South
San Francisco, CA 94158
Dr. Rima Arnaout is an Assistant Professor in Medicine (Cardiology) and a member of the UCSF Institute for Computational Health Sciences (ICHS). She is a physician-scientist with a background in genetics, clinical research and programming, and a practicing cardiologist board-certified in multi-modality cardiovascular imaging. Improving the resolution and accuracy of cardiovascular phenotypes will lead to novel insights and therapies. This can occur by drilling down—understanding the genetic and cellular mechanism of a particular disease—or going broad, using computational means to analyze precision phenotypes at scale. Dr. Arnaout is currently developing computational methods to bring precision phenotyping to echocardiography. Her background as a physician-scientist informs the future scope of this work as a technology that can transform non-invasive imaging into a big-data tool for both research and clinical use. She also uses the zebrafish animal model to study cardiovascular developmental gene function and to model human cardiovascular disease.
Education and Training
|Location||Degree or Training||Specialty||Date|
|Harvard Medical School||MD||Medicine|
|University of California, San Francisco||Cardiology Fellowship|
|Massachusetts General Hospital||Internal Medicine Residency|
|Massachusetts Institute of Technology||SB||Biology, Bioengineering|
Cardiovascular Genetic and Genomics, Congenital Heart Disease, Data Science, Echocardiography, General Cardiology, Heart Development, Machine Learning, Multi-modality Imaging, ZebrafishAwards and Honors
Sarnoff Scholar Award, Sarnoff Cardiovascular Research Foundation, 2013-2015
Pierre and Christine Lamond Research Fellow in Cardiology, UCSF, 2012-2013
National Institutes of Health Loan Repayment Program Award, NIH, 2011-2013
Sarnoff Fellow Award, Sarnoff Cardiovascular Research Foundation, 2005-2006
AAAS Mass Media Science and Engineering Fellowship Award, Voice of America, 2004-2005
|Project Title||Project Number||Fiscal Year|
|Genetics and Structure of Trabecular Myocardium in Development and Disease||K08HL125945||2020|
|Genetic Analyst of Early Conduction System Development||F32HL110489||2013|
Madani A, Arnaout R, Mofrad M, Arnaout R.. Fast and accurate classification of echocardiograms using deep learning. ArXiv e-prints. 2017; (arXiv:1706).
Brown D, Samsa L, Ito C, Ma H, Arnaout R, Qian L, Liu J.. Neuregulin-1 is essential for nerve plexus formation during cardiac maturation. Journal of Molecular and Cellular Medicine. doi: 10.1111/jcmm.13408. 2017.
Orr N, Arnaout R, Gula LJ, Spears DA, Leong-Sit P, Li Q, Tarhuni W, Reischauer S, Chauhan VS, Borkovich M, Uppal S, Adler A, Coughlin SR, Stainier DY, Gollob MH. A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation. Nat Commun. 2016 Apr 12; 7:11303.
Reischauer S, Arnaout R, Ramadass R, Stainier DY. Actin binding GFP allows 4D in vivo imaging of myofilament dynamics in the zebrafish heart and the identification of Erbb2 signaling as a remodeling factor of myofibril architecture. Circ Res. 2014 Oct 24; 115(10):845-56.
Chi NC, Shaw RM, Jungblut B, Huisken J, Ferrer T, Arnaout R, Scott I, Beis D, Xiao T, Baier H, Jan LY, Tristani-Firouzi M, Stainier DY. Genetic and physiologic dissection of the vertebrate cardiac conduction system. PLoS Biol. 2008 May 13; 6(5):e109.