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UCSF Cardiology
Transforming medicine through innovation and collaboration.
Department of Medicine

Faculty Profiles

Rima Arnaout, MD
Assistant Professor

555 Mission Bay Blvd South
San Francisco, CA 94158
[email protected]

Dr. Rima Arnaout is an Assistant Professor in Medicine (Cardiology) and a member of the UCSF Institute for Computational Health Sciences (ICHS). She is a physician-scientist with a background in genetics, clinical research and programming, and a practicing cardiologist board-certified in multi-modality cardiovascular imaging. Improving the resolution and accuracy of cardiovascular phenotypes will lead to novel insights and therapies. This can occur by drilling down—understanding the genetic and cellular mechanism of a particular disease—or going broad, using computational means to analyze precision phenotypes at scale. Dr. Arnaout is currently developing computational methods to bring precision phenotyping to echocardiography. Her background as a physician-scientist informs the future scope of this work as a technology that can transform non-invasive imaging into a big-data tool for both research and clinical use. She also uses the zebrafish animal model to study cardiovascular developmental gene function and to model human cardiovascular disease.

Education and Training

Location Degree or Training Specialty Date
Harvard Medical School MD Medicine
Massachusetts General Hospital Internal Medicine Residency
Massachusetts Institute of Technology SB Biology, Bioengineering
University of California, San Francisco Cardiology Fellowship


Cardiovascular Genetic and Genomics, Congenital Heart Disease, Data Science, Echocardiography, General Cardiology, Heart Development, Machine Learning, Multi-modality Imaging, Zebrafish

Awards and Honors
2013   Sarnoff Scholar Award, Sarnoff Cardiovascular Research Foundation, 2013-2015
2012   Pierre and Christine Lamond Research Fellow in Cardiology, UCSF, 2012-2013
2011   National Institutes of Health Loan Repayment Program Award, NIH, 2011-2013
2005   Sarnoff Fellow Award, Sarnoff Cardiovascular Research Foundation, 2005-2006
2004   AAAS Mass Media Science and Engineering Fellowship Award, Voice of America, 2004-2005

Awarded Grants

Project Title Project Number Fiscal Year
Genetics and Structure of Trabecular Myocardium in Development and Disease K08HL125945 2020
Genetic Analyst of Early Conduction System Development F32HL110489 2013
Recent Articles (12)

Guerra A, Germano RF, Stone O, Arnaout R, Guenther S, Ahuja S, Uribe V, Vanhollebeke B, Stainier DY, Reischauer S. Distinct myocardial lineages break atrial symmetry during cardiogenesis in zebrafish. Elife. 2018 May 15; 7.

Gut P, Reischauer S, Stainier DYR, Arnaout R. LITTLE FISH, BIG DATA: ZEBRAFISH AS A MODEL FOR CARDIOVASCULAR AND METABOLIC DISEASE. Physiol Rev. 2017 Jul 01; 97(3):889-938.

Madani A, Arnaout R, Mofrad M, Arnaout R.. Fast and accurate classification of echocardiograms using deep learning. ArXiv e-prints. 2017; (arXiv:1706).

Brown D, Samsa L, Ito C, Ma H, Arnaout R, Qian L, Liu J.. Neuregulin-1 is essential for nerve plexus formation during cardiac maturation. Journal of Molecular and Cellular Medicine. doi: 10.1111/jcmm.13408. 2017.

Orr N, Arnaout R, Gula LJ, Spears DA, Leong-Sit P, Li Q, Tarhuni W, Reischauer S, Chauhan VS, Borkovich M, Uppal S, Adler A, Coughlin SR, Stainier DY, Gollob MH. A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation. Nat Commun. 2016 Apr 12; 7:11303.

Arnaout R, Reischauer S, Stainier DY. Recovery of adult zebrafish hearts for high-throughput applications. J Vis Exp. 2014 Dec 12; (94).

Reischauer S, Arnaout R, Ramadass R, Stainier DY. Actin binding GFP allows 4D in vivo imaging of myofilament dynamics in the zebrafish heart and the identification of Erbb2 signaling as a remodeling factor of myofibril architecture. Circ Res. 2014 Oct 24; 115(10):845-56.

Arnaout R, Stainier DY. Developmental biology: physics adds a twist to gut looping. Curr Biol. 2011 Oct 25; 21(20):R854-7.

Arnaout R, Thorson A. Late Recognition of Malignant Vasovagal Syncope. Card Electrophysiol Clin. 2010 Jun; 2(2):281-283.

Chi NC, Shaw RM, Jungblut B, Huisken J, Ferrer T, Arnaout R, Scott I, Beis D, Xiao T, Baier H, Jan LY, Tristani-Firouzi M, Stainier DY. Genetic and physiologic dissection of the vertebrate cardiac conduction system. PLoS Biol. 2008 May 13; 6(5):e109.

Arnaout R, Ferrer T, Huisken J, Spitzer K, Stainier DY, Tristani-Firouzi M, Chi NC. Zebrafish model for human long QT syndrome. Proc Natl Acad Sci U S A. 2007 Jul 03; 104(27):11316-21.

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