Faculty ProfilesRima Arnaout, MD
555 Mission Bay Blvd South
San Francisco, CA 94158
Dr. Rima Arnaout is an Assistant Professor in Medicine (Cardiology) and a member of the UCSF Institute for Computational Health Sciences (ICHS). She is a physician-scientist with a background in genetics, clinical research and programming, and a practicing cardiologist board-certified in multi-modality cardiovascular imaging. Improving the resolution and accuracy of cardiovascular phenotypes will lead to novel insights and therapies. This can occur by drilling down—understanding the genetic and cellular mechanism of a particular disease—or going broad, using computational means to analyze precision phenotypes at scale. Dr. Arnaout is currently developing computational methods to bring precision phenotyping to echocardiography. Her background as a physician-scientist informs the future scope of this work as a technology that can transform non-invasive imaging into a big-data tool for both research and clinical use. She also uses the zebrafish animal model to study cardiovascular developmental gene function and to model human cardiovascular disease.
Education and Training
|Location||Degree or Training||Specialty||Date|
|Harvard Medical School||MD||Medicine|
|Massachusetts General Hospital||Internal Medicine Residency|
|Massachusetts Institute of Technology||SB||Biology, Bioengineering|
|University of California, San Francisco||Cardiology Fellowship|
Cardiovascular Genetic and Genomics, Congenital Heart Disease, Data Science, Echocardiography, General Cardiology, Heart Development, Machine Learning, Multi-modality Imaging, ZebrafishAwards and Honors
Sarnoff Scholar Award, Sarnoff Cardiovascular Research Foundation, 2013-2015
Pierre and Christine Lamond Research Fellow in Cardiology, UCSF, 2012-2013
National Institutes of Health Loan Repayment Program Award, NIH, 2011-2013
Sarnoff Fellow Award, Sarnoff Cardiovascular Research Foundation, 2005-2006
AAAS Mass Media Science and Engineering Fellowship Award, Voice of America, 2004-2005
|Project Title||Project Number||Fiscal Year|
|Genetics and Structure of Trabecular Myocardium in Development and Disease||K08HL125945||2020|
|Genetic Analyst of Early Conduction System Development||F32HL110489||2013|
Guerra A, Germano RF, Stone O, Arnaout R, Guenther S, Ahuja S, Uribe V, Vanhollebeke B, Stainier DY, Reischauer S. Distinct myocardial lineages break atrial symmetry during cardiogenesis in zebrafish. Elife. 2018 May 15; 7.
Madani A, Arnaout R, Mofrad M, Arnaout R.. Fast and accurate classification of echocardiograms using deep learning. ArXiv e-prints. 2017; (arXiv:1706).
Brown D, Samsa L, Ito C, Ma H, Arnaout R, Qian L, Liu J.. Neuregulin-1 is essential for nerve plexus formation during cardiac maturation. Journal of Molecular and Cellular Medicine. doi: 10.1111/jcmm.13408. 2017.
Orr N, Arnaout R, Gula LJ, Spears DA, Leong-Sit P, Li Q, Tarhuni W, Reischauer S, Chauhan VS, Borkovich M, Uppal S, Adler A, Coughlin SR, Stainier DY, Gollob MH. A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation. Nat Commun. 2016 Apr 12; 7:11303.
Reischauer S, Arnaout R, Ramadass R, Stainier DY. Actin binding GFP allows 4D in vivo imaging of myofilament dynamics in the zebrafish heart and the identification of Erbb2 signaling as a remodeling factor of myofibril architecture. Circ Res. 2014 Oct 24; 115(10):845-56.
Chi NC, Shaw RM, Jungblut B, Huisken J, Ferrer T, Arnaout R, Scott I, Beis D, Xiao T, Baier H, Jan LY, Tristani-Firouzi M, Stainier DY. Genetic and physiologic dissection of the vertebrate cardiac conduction system. PLoS Biol. 2008 May 13; 6(5):e109.