Faculty ProfilesVaikom Mahadevan, MD
505 Parnassus Avenue
San Francisco, CA 94117
Dr. Vaikom S Mahadevan joined UCSF from the UK in July 2014 as Director of Structural and Adult Congenital cardiac Interventions and the Wiliam W Parmley Endowed Chair in Cardiology and Associate Professor of Medicine. Following completion of his intital medical training in Stanley Medical College in India Dr. Mahadevan did his higher Internal Medicine and Cardiology training in the United Kingdom. Subsequent to this he was an advanced British Heart Foundation fellow in Adult congenital Heart Disease (ACHD) and Intervention at the Royal Brompton Hospital, London and did a further fellowship in the same specialities at Toronto General Hospital, Toronto, Canada. He joined as a Consultant Cardiologist at the Manchester Royal Infirmary, Central Manchester University Hospitals in 2005 and held this position until his move to UCSF. He established a large ACHD and structural cardiac Intervention program in Manchester and was the Lead clinician (Director) for both of these programs. Apart from ACHD and related intervention he has a major interest in transcatheter valvular implantation, since he performed his first implants in the UK in 2007 and has performed these interventions in all four positions in the heart including pioneering the first successful transcatheter valve implant in the mitral position. He also has expertise in the management of pulmonary hypertension in ACHD patients. Dr. Mahadevan is a proctor for implantation of transcatheter valves and in this role has trained a number of interventional cardiologists in Western Europe and internationally. He has served as invited faculty in a number of international meetings and on invitation performs complex intervention procedures overseas.
Dr. Mahadevan's major research interests include clinical ACHD, ACHD and transcatheter valvar intervention and has published a number of papers in these areas. His basic science research interests include looking at arrythmias in adult patients with repaired Tetralogy of Fallot (ToF). He has two major grants from the British Heart Foundation both leading to completion of Doctoral projects by students under his supervision. He also has been the principal site investigator for a number of clinical studies including registries of pulmonic valve implantation in Europe.
Education and Training
|Location||Degree or Training||Specialty||Date|
|Royal College of Physicians (London)||MRCP||1997|
|Stanley Medical College||MD (Internal Medicine)||1993|
|Stanley Medical College||MBBS||University of Madras||1990|
Adult congenital heart disease (ACHD), Congenital cardiac interventions, Fontan circulation, Pulmonary hypertension in ACHD including Eisenmenger's syndrome, Structural cardiac interventions including transcatheter valve implantations, Tetralogy of FallotAwards and Honors
Fellow of Royal College of physicians, Royal College of Physicians, London, UK, 2014
Recent Articles (64)
Kallianos K, Henry TS, Yeghiazarians Y, Zimmet J, Shunk KA, Tseng EE, Mahadevan V, Hope MD. Ferumoxytol MRA for transcatheter aortic valve replacement planning with renal insufficiency. Int J Cardiol. 2016 Dec 30.
Agarwal A, Harris IS, Mahadevan VS, Foster E. Coexistence of abnormal systolic motion of mitral valve in a consecutive group of 324 adult Tetralogy of Fallot patients assessed with echocardiography. Open Heart. 2016; 3(2):e000518.
Temple IP, Logantha SJ, Absi M, Zhang Y, Pervolaraki E, Yanni J, Atkinson A, Petkova M, Quigley GM, Castro S, Drinkhill M, Schneider H, Monfredi O, Cartwright E, Zi M, Yamanushi TT, Mahadevan VS, Gurney AM, White E, Zhang H, Hart G, Boyett MR, Dobrzynski H. Atrioventricular Node Dysfunction and Ion Channel Transcriptome in Pulmonary Hypertension. Circ Arrhythm Electrophysiol. 2016 Dec; 9(12).
Calvert PA, Northridge DB, Malik IS, Shapiro L, Ludman P, Qureshi SA, Mullen M, Henderson R, Turner M, Been M, Walsh KP, Casserly I, Morrison L, Walker NL, Thomson J, Spence MS, Mahadevan VS, Hoye A, MacCarthy PA, Daniels MJ, Clift P, Davies WR, Adamson PD, Morgan G, Aggarwal SK, Ismail Y, Ormerod JO, Khan HR, Chandran SS, de Giovanni J, Rana BS, Ormerod O, Hildick-Smith D. Percutaneous Device Closure of Paravalvular Leak: Combined Experience From the United Kingdom and Ireland. Circulation. 2016 Sep 27; 134(13):934-44.
Shah AH, Horlick EM, Eicken A, Asnes JD, Bocks ML, Boudjemline Y, Cabalka AK, Fagan TE, Schubert S, Mahadevan VS, Dvir D, Osten M, McElhinney DB. Transcatheter valve implantation for right atrium-to-right ventricle conduit obstruction or regurgitation after modified Björk-fontan procedure. Catheter Cardiovasc Interv. 2017 Feb 01; 89(2):298-305.
Guerrero M, Dvir D, Himbert D, Urena M, Eleid M, Wang DD, Greenbaum A, Mahadevan VS, Holzhey D, O'Hair D, Dumonteil N, Rodés-Cabau J, Piazza N, Palma JH, DeLago A, Ferrari E, Witkowski A, Wendler O, Kornowski R, Martinez-Clark P, Ciaburri D, Shemin R, Alnasser S, McAllister D, Bena M, Kerendi F, Pavlides G, Sobrinho JJ, Attizzani GF, George I, Nickenig G, Fassa AA, Cribier A, Bapat V, Feldman T, Rihal C, Vahanian A, Webb J, O'Neill W. Transcatheter Mitral Valve Replacement in Native Mitral Valve Disease With Severe Mitral Annular Calcification: Results From the First Multicenter Global Registry. JACC Cardiovasc Interv. 2016 Jul 11; 9(13):1361-71.
Rendon A, Hamid T, Kanaganayagam G, Karunaratne D, Mahadevan VS. Annular sizing using real-time three-dimensional intracardiac echocardiography-guided trans-catheter aortic valve replacement. Open Heart. 2016; 3(1):e000316.
Monfredi O, Heward E, Griffiths L, Condliffe R, Mahadevan VS. Effect of dual pulmonary vasodilator therapy in pulmonary arterial hypertension associated with congenital heart disease: a retrospective analysis. Open Heart. 2016; 3(1):e000399.
Mahadevan VS, Manoly I, Hasan R. 2-Year Follow-Up of the First in Human Transapical Implantation of Transcatheter Inverted Aortic Valve to Treat Native Mitral Valve Stenosis. JACC Cardiovasc Interv. 2015 Dec 28; 8(15):e247-9.
Hamid T, Motwani M, Schneider H, Dua JS, Hoschtitzky A, Clarke B, Mahadevan VS. Benefit of endovascular stenting for aortic coarctation on systemic hypertension in adults. Arch Cardiovasc Dis. 2015 Dec; 108(12):626-33.
Hamid T, Choudhury TR, Anderson SG, Hashmi I, Chowdhary S, Hesketh Roberts D, Fraser DG, Hasan R, Mahadevan VS, Levy R. Does the CHA2DS2-Vasc score predict procedural and short-term outcomes in patients undergoing transcatheter aortic valve implantation? Open Heart. 2015; 2(1):e000170.
Hamid T, Jamallulail SI, Clarke B, Mahadevan VS. Dual Arterial Access for Stenting of Aortic Coarctation in Patients with Near-Total Descending Aortic Interruption. Cardiol Ther. 2015 Dec; 4(2):203-7.
Kesarwani M, Ports TA, Rao RK, Mahadevan VS. First-in-Human Transcatheter Pulmonic Valve Implantation Through a Tricuspid Valve Bioprosthesis to Treat Native Pulmonary Valve Regurgitation Caused by Carcinoid Syndrome. JACC Cardiovasc Interv. 2015 Aug 24; 8(10):e161-3.
Temple IP, Monfredi O, Quigley G, Schneider H, Zi M, Cartwright EJ, Boyett MR, Mahadevan VS, Hart G. Macitentan treatment retards the progression of established pulmonary arterial hypertension in an animal model. Int J Cardiol. 2014 Dec 15; 177(2):423-8.
Cunnington C, Hoschtitzky JA, Hasan R, Clarke B, Mahadevan VS. Percutaneous tricuspid valve-in-valve implantation in Ebstein's anomaly: one-year follow-up of valve function. Int J Cardiol. 2014 Jun 15; 174(2):e77-8.
Abdelbar A, Mahadevan VS, Austin C, Hoschtitzky JA. Late bidirectional glenn anastomosis in a 54-year-old patient with unoperated functionally univentricular heart. World J Pediatr Congenit Heart Surg. 2013 Oct; 4(4):444-6.
Thomson JD, Hildick-Smith D, Clift P, Morgan G, Daniels M, Henderson R, Spence MS, Mahadevan VS, Crossland D, Ormerod O. Patent foramen ovale closure with the Gore septal occluder: initial UK experience. Catheter Cardiovasc Interv. 2014 Feb 15; 83(3):467-73.
Hasan R, Mahadevan VS, Schneider H, Clarke B. First in human transapical implantation of an inverted transcatheter aortic valve prosthesis to treat native mitral valve stenosis. Circulation. 2013 Aug 6; 128(6):e74-6.
Khawaja MZ, Sohal M, Valli H, Dworakowski R, Pettit SJ, Roy D, Newton J, Schneider H, Manoharan G, Doshi S, Muir D, Roberts D, Nolan J, Gunning M, Densem C, Spence MS, Chowdhary S, Mahadevan VS, Brecker SJ, Maccarthy P, Mullen M, Stables RH, Prendergast BD, de Belder A, Thomas M, Redwood S, Hildick-Smith D. Standalone balloon aortic valvuloplasty: indications and outcomes from the UK in the transcatheter valve era. Catheter Cardiovasc Interv. 2013 Feb; 81(2):366-73.
Hamid T, Rajagopal R, Pius C, Clarke B, Mahadevan VS. Preclosure of large-sized venous access sites in adults undergoing transcatheter structural interventions. Catheter Cardiovasc Interv. 2013 Mar; 81(4):586-90.
Hamid T, Murphy G, Mahadevan VS. Treatment of multiple residual complex coronary to right ventricular fistulae with covered stents following previous coil embolization. Exp Clin Cardiol. 2012 Sep; 17(3):146-7.
Monfredi O, Luckie M, Mirjafari H, Willard T, Buckley H, Griffiths L, Clarke B, Mahadevan VS. Percutaneous device closure of atrial septal defect results in very early and sustained changes of right and left heart function. Int J Cardiol. 2013 Aug 20; 167(4):1578-84.
Hamid T, Hasan R, Mahadevan VS. Transient severe aortic regurgitation and left ventricular dysfunction due to a stuck leaflet in a patient undergoing percutaneous transcatheter aortic valve implantation. Cardiol Young. 2013 Feb; 23(1):108-10.
Monfredi O, Griffiths L, Clarke B, Mahadevan VS. Efficacy and safety of bosentan for pulmonary arterial hypertension in adults with congenital heart disease. Am J Cardiol. 2011 Nov 15; 108(10):1483-8.
Ellison S, Lamb J, Haines A, O'Dell S, Thomas G, Sethi S, Ratcliffe J, Chisholm S, Vaughan J, Mahadevan VS. A guide for identification and continuing care of adult congenital heart disease patients in primary care. Int J Cardiol. 2013 Mar 10; 163(3):260-5.
Nair S, Fath-Ordoubadi F, Clarke B, El-Omar M, Foley J, Fraser DG, Mahadevan VS, Neyses L, Khattar RS, Mamas MA. Late outcomes of drug eluting and bare metal stents in saphenous vein graft percutaneous coronary intervention. EuroIntervention. 2011 Mar; 6(8):985-91.
Hamid T, Eichhöfer J, Clarke B, Mahadevan VS. Aortic balloon valvuloplasty: is there still a role in high-risk patients in the era of percutaneous aortic valve replacement? J Interv Cardiol. 2010 Aug; 23(4):358-61.
Mahadevan VS, Gomperts N, Haberer K, Silversides C, Benson LN, McLaughlin PR, Horlick EM. Transcatheter closure of atrial septal defects with multiple devices in adults: procedural and clinical outcomes. Int J Cardiol. 2009 Apr 17; 133(3):359-63.
Mahadevan VS, Jimeno S, Benson LN, McLaughlin PR, Horlick EM. Pre-closure of femoral venous access sites used for large-sized sheath insertion with the Perclose device in adults undergoing cardiac intervention. Heart. 2008 May; 94(5):571-2.
Ali NF, Mahadevan VS, Muir A, Maguire C, Young D, Campalani G, Campbell NP, Danton MH. The influence of prosthesis size and design on exercise dynamics after aortic valve replacement. J Heart Valve Dis. 2006 Nov; 15(6):755-62.
Mahadevan VS, Horlick EM, Benson LN, McLaughlin PR. Transcatheter closure of aortic sinus to left atrial fistula caused by erosion of Amplatzer septal occluder. Catheter Cardiovasc Interv. 2006 Nov; 68(5):749-53.
Mahadevan VS, Earley M, McClements B. Open access echocardiography has diagnostic yield similar to outpatient echocardiography and is highly rated by general practitioners and patients. Int J Cardiol. 2005 Mar 30; 99(3):389-93.
Mahadevan VS, McCarty D, Adgey AA. Platelet GPIIb/IIIa receptor blockers for failed thrombolysis in acute myocardial infarction, alone or as adjunct to other rescue therapies. Eur Heart J. 2002 Oct; 23(19):1490-1.
Mahadevan VS, Adgey AA. ST depression in ECG at entry indicates severe coronary lesions and large benefits of an early invasive treatment strategy in unstable coronary artery disease--the FRISC II ECG substudy. Fragmin and Fast Revascularisation during Instability in Coronary artery disease. Eur Heart J. 2002 Jan; 23(1):3-5.