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UCSF Cardiology
Transforming medicine through innovation and collaboration.
Department of Medicine

Faculty Profiles

Vaikom Mahadevan, MD

505 Parnassus Avenue
San Francisco, CA 94143

Dr. Vaikom S Mahadevan joined UCSF from the UK in July 2014 as Director of Structural and Adult Congenital cardiac Interventions and the Wiliam W Parmley Endowed Chair in Cardiology and Associate Professor of Medicine. Following completion of his intital medical training in Stanley Medical College in India Dr. Mahadevan did his higher Internal Medicine and Cardiology training in the United Kingdom. Subsequent to this he was an advanced British Heart Foundation fellow in Adult congenital Heart Disease (ACHD) and Intervention at the Royal Brompton Hospital, London and did a further fellowship in the same specialities at Toronto General Hospital, Toronto, Canada. He joined as a Consultant Cardiologist at the Manchester Royal Infirmary, Central Manchester University Hospitals in 2005 and held this position until his move to UCSF. He established a large ACHD and structural cardiac Intervention program in Manchester and was the Lead clinician (Director) for both of these programs. Apart from ACHD and related intervention he has a major interest in transcatheter valvular implantation, since he performed his first implants in the UK in 2007 and has performed these interventions in all four positions in the heart including pioneering the first successful transcatheter valve implant in the mitral position. He also has expertise in the management of pulmonary hypertension in ACHD patients. Dr. Mahadevan is a proctor for implantation of transcatheter valves and in this role has trained a number of interventional cardiologists in Western Europe and internationally. He has served as invited faculty in a number of international meetings and on invitation performs complex intervention procedures overseas.

Dr. Mahadevan's major research interests include clinical ACHD, ACHD and transcatheter valvar intervention and has published a number of papers in these areas. His basic science research interests include looking at arrythmias in adult patients with repaired Tetralogy of Fallot (ToF). He has two major grants from the British Heart Foundation both leading to completion of Doctoral projects by students under his supervision. He also has been the principal site investigator for a number of clinical studies including registries of pulmonic valve implantation in Europe.

Education and Training

Location Degree or Training Specialty Date
Royal College of Physicians (London) MRCP 1997
Stanley Medical College MD (Internal Medicine) 1993
Stanley Medical College MBBS University of Madras 1990


Adult congenital heart disease (ACHD), Congenital cardiac interventions, Fontan circulation, Pulmonary hypertension in ACHD including Eisenmenger's syndrome, Structural cardiac interventions including transcatheter valve implantations, Tetralogy of Fallot

Awards and Honors
2014   Fellow of Royal College of physicians, Royal College of Physicians, London, UK, 2014

Recent Articles (65)

Mukai K, Burris NS, Mahadevan VS, Foster ED, Ordovas KG, Hope MD. 4D flow image quality with blood pool contrast: a comparison of gadofosveset trisodium and ferumoxytol. Int J Cardiovasc Imaging. 2017 Sep 08.

Ganesan G, Paul GJ, Mahadevan VS. Transcatheter closure of left ventricle to right atrial communication using cera duct occluder. Indian Heart J. 2017 May - Jun; 69(3):341-344.

Kallianos K, Henry TS, Yeghiazarians Y, Zimmet J, Shunk KA, Tseng EE, Mahadevan V, Hope MD. Ferumoxytol MRA for transcatheter aortic valve replacement planning with renal insufficiency. Int J Cardiol. 2017 Mar 15; 231:255-257.

Agarwal A, Harris IS, Mahadevan VS, Foster E. Coexistence of abnormal systolic motion of mitral valve in a consecutive group of 324 adult Tetralogy of Fallot patients assessed with echocardiography. Open Heart. 2016; 3(2):e000518.

Temple IP, Logantha SJ, Absi M, Zhang Y, Pervolaraki E, Yanni J, Atkinson A, Petkova M, Quigley GM, Castro S, Drinkhill M, Schneider H, Monfredi O, Cartwright E, Zi M, Yamanushi TT, Mahadevan VS, Gurney AM, White E, Zhang H, Hart G, Boyett MR, Dobrzynski H. Atrioventricular Node Dysfunction and Ion Channel Transcriptome in Pulmonary Hypertension. Circ Arrhythm Electrophysiol. 2016 Dec; 9(12).

Zier LS, Sievert H, Mahadevan VS. To close or not to close: contemporary indications for patent foramen ovale closure. Expert Rev Cardiovasc Ther. 2016 Nov; 14(11):1235-1244.

Calvert PA, Northridge DB, Malik IS, Shapiro L, Ludman P, Qureshi SA, Mullen M, Henderson R, Turner M, Been M, Walsh KP, Casserly I, Morrison L, Walker NL, Thomson J, Spence MS, Mahadevan VS, Hoye A, MacCarthy PA, Daniels MJ, Clift P, Davies WR, Adamson PD, Morgan G, Aggarwal SK, Ismail Y, Ormerod JO, Khan HR, Chandran SS, de Giovanni J, Rana BS, Ormerod O, Hildick-Smith D. Percutaneous Device Closure of Paravalvular Leak: Combined Experience From the United Kingdom and Ireland. Circulation. 2016 Sep 27; 134(13):934-44.

Shah AH, Horlick EM, Eicken A, Asnes JD, Bocks ML, Boudjemline Y, Cabalka AK, Fagan TE, Schubert S, Mahadevan VS, Dvir D, Osten M, McElhinney DB. Transcatheter valve implantation for right atrium-to-right ventricle conduit obstruction or regurgitation after modified Björk-fontan procedure. Catheter Cardiovasc Interv. 2017 Feb 01; 89(2):298-305.

Guerrero M, Dvir D, Himbert D, Urena M, Eleid M, Wang DD, Greenbaum A, Mahadevan VS, Holzhey D, O'Hair D, Dumonteil N, Rodés-Cabau J, Piazza N, Palma JH, DeLago A, Ferrari E, Witkowski A, Wendler O, Kornowski R, Martinez-Clark P, Ciaburri D, Shemin R, Alnasser S, McAllister D, Bena M, Kerendi F, Pavlides G, Sobrinho JJ, Attizzani GF, George I, Nickenig G, Fassa AA, Cribier A, Bapat V, Feldman T, Rihal C, Vahanian A, Webb J, O'Neill W. Transcatheter Mitral Valve Replacement in Native Mitral Valve Disease With Severe Mitral Annular Calcification: Results From the First Multicenter Global Registry. JACC Cardiovasc Interv. 2016 Jul 11; 9(13):1361-71.

Rendon A, Hamid T, Kanaganayagam G, Karunaratne D, Mahadevan VS. Annular sizing using real-time three-dimensional intracardiac echocardiography-guided trans-catheter aortic valve replacement. Open Heart. 2016; 3(1):e000316.

Monfredi O, Heward E, Griffiths L, Condliffe R, Mahadevan VS. Effect of dual pulmonary vasodilator therapy in pulmonary arterial hypertension associated with congenital heart disease: a retrospective analysis. Open Heart. 2016; 3(1):e000399.

Mahadevan VS, Manoly I, Hasan R. 2-Year Follow-Up of the First in Human Transapical Implantation of Transcatheter Inverted Aortic Valve to Treat Native Mitral Valve Stenosis. JACC Cardiovasc Interv. 2015 Dec 28; 8(15):e247-e249.

Mahadevan VS, Dua J, Hoschtitzky A. Combined tricuspid and pulmonic valve percutaneous replacement in a patient with a Glenn shunt. Int J Cardiol. 2016 Feb 01; 204:128-30.

Hamid T, Motwani M, Schneider H, Dua JS, Hoschtitzky A, Clarke B, Mahadevan VS. Benefit of endovascular stenting for aortic coarctation on systemic hypertension in adults. Arch Cardiovasc Dis. 2015 Dec; 108(12):626-33.

Hamid T, Choudhury TR, Anderson SG, Hashmi I, Chowdhary S, Hesketh Roberts D, Fraser DG, Hasan R, Mahadevan VS, Levy R. Does the CHA2DS2-Vasc score predict procedural and short-term outcomes in patients undergoing transcatheter aortic valve implantation? Open Heart. 2015; 2(1):e000170.

Hamid T, Jamallulail SI, Clarke B, Mahadevan VS. Dual Arterial Access for Stenting of Aortic Coarctation in Patients with Near-Total Descending Aortic Interruption. Cardiol Ther. 2015 Dec; 4(2):203-7.

Kesarwani M, Ports TA, Rao RK, Mahadevan VS. First-in-Human Transcatheter Pulmonic Valve Implantation Through a Tricuspid Valve Bioprosthesis to Treat Native Pulmonary Valve Regurgitation Caused by Carcinoid Syndrome. JACC Cardiovasc Interv. 2015 Aug 24; 8(10):e161-3.

Soni K, Kesarwani M, Badhwar N, Mahadevan VS. Percutaneous Closure of a Residual Left Atrial Appendage Leak After Lariat Procedure. JACC Cardiovasc Interv. 2015 Jun; 8(7):998-1000.

Hamid T, Choudhury TR, Clarke B, Mahadevan VS. Pre-closure of Large-Sized Arterial Access Sites in Adults Undergoing Transcatheter Structural Interventions. Cardiol Ther. 2015 Jun; 4(1):59-63.

Mahadevan VS, Jenkins P, Vohra A, Hasan R, Andreas Hoschtitzky J. Hybrid right atrial approach for trans-catheter pulmonary valve implantation. Int J Cardiol. 2015 Jan 15; 178:44-5.

Temple IP, Monfredi O, Quigley G, Schneider H, Zi M, Cartwright EJ, Boyett MR, Mahadevan VS, Hart G. Macitentan treatment retards the progression of established pulmonary arterial hypertension in an animal model. Int J Cardiol. 2014 Dec 15; 177(2):423-8.

Manoly I, Mahadevan VS, Hoschtitzky JA. Hybrid approach to closure of an acquired coronary-cameral fistula. Ann Thorac Surg. 2014 Sep; 98(3):e59-61.

Cunnington C, Hoschtitzky JA, Hasan R, Clarke B, Mahadevan VS. Percutaneous tricuspid valve-in-valve implantation in Ebstein's anomaly: one-year follow-up of valve function. Int J Cardiol. 2014 Jun 15; 174(2):e77-8.

Abdelbar A, Mahadevan VS, Austin C, Hoschtitzky JA. Late bidirectional glenn anastomosis in a 54-year-old patient with unoperated functionally univentricular heart. World J Pediatr Congenit Heart Surg. 2013 Oct; 4(4):444-6.

Thomson JD, Hildick-Smith D, Clift P, Morgan G, Daniels M, Henderson R, Spence MS, Mahadevan VS, Crossland D, Ormerod O. Patent foramen ovale closure with the Gore septal occluder: initial UK experience. Catheter Cardiovasc Interv. 2014 Feb 15; 83(3):467-73.

Hasan R, Mahadevan VS, Schneider H, Clarke B. First in human transapical implantation of an inverted transcatheter aortic valve prosthesis to treat native mitral valve stenosis. Circulation. 2013 Aug 06; 128(6):e74-6.

Cunnington C, Hampshaw SA, Mahadevan VS. Utility of real-time three-dimensional intracardiac echocardiography for patent foramen ovale closure. Heart. 2013 Dec; 99(23):1789-90.

Khawaja MZ, Sohal M, Valli H, Dworakowski R, Pettit SJ, Roy D, Newton J, Schneider H, Manoharan G, Doshi S, Muir D, Roberts D, Nolan J, Gunning M, Densem C, Spence MS, Chowdhary S, Mahadevan VS, Brecker SJ, Maccarthy P, Mullen M, Stables RH, Prendergast BD, de Belder A, Thomas M, Redwood S, Hildick-Smith D. Standalone balloon aortic valvuloplasty: indications and outcomes from the UK in the transcatheter valve era. Catheter Cardiovasc Interv. 2013 Feb; 81(2):366-73.

D'Alto M, Mahadevan VS. Pulmonary arterial hypertension associated with congenital heart disease. Eur Respir Rev. 2012 Dec 01; 21(126):328-37.

Hamid T, Rajagopal R, Pius C, Clarke B, Mahadevan VS. Preclosure of large-sized venous access sites in adults undergoing transcatheter structural interventions. Catheter Cardiovasc Interv. 2013 Mar; 81(4):586-90.

Hamid T, Murphy G, Mahadevan VS. Treatment of multiple residual complex coronary to right ventricular fistulae with covered stents following previous coil embolization. Exp Clin Cardiol. 2012 Sep; 17(3):146-7.

Dimarakis I, Mahadevan VS, Hoschtitzky JA. Congenital and acquired heart disease converge: ischaemic heart disease with a background of scimitar syndrome. Eur Heart J. 2012 Dec; 33(23):2991.

Monfredi O, Luckie M, Mirjafari H, Willard T, Buckley H, Griffiths L, Clarke B, Mahadevan VS. Percutaneous device closure of atrial septal defect results in very early and sustained changes of right and left heart function. Int J Cardiol. 2013 Aug 20; 167(4):1578-84.

Hamid T, Hasan R, Mahadevan VS. Transient severe aortic regurgitation and left ventricular dysfunction due to a stuck leaflet in a patient undergoing percutaneous transcatheter aortic valve implantation. Cardiol Young. 2013 Feb; 23(1):108-10.

Hamid T, Clarke B, Mahadevan V. Transcatheter interventions for multiple lesions in adults with congenital heart disease. Exp Clin Cardiol. 2012; 17(2):59-62.

Monfredi O, Griffiths L, Clarke B, Mahadevan VS. Efficacy and safety of bosentan for pulmonary arterial hypertension in adults with congenital heart disease. Am J Cardiol. 2011 Nov 15; 108(10):1483-8.

Ellison S, Lamb J, Haines A, O'Dell S, Thomas G, Sethi S, Ratcliffe J, Chisholm S, Vaughan J, Mahadevan VS. A guide for identification and continuing care of adult congenital heart disease patients in primary care. Int J Cardiol. 2013 Mar 10; 163(3):260-5.

Nair S, Fath-Ordoubadi F, Clarke B, El-Omar M, Foley J, Fraser DG, Mahadevan VS, Neyses L, Khattar RS, Mamas MA. Late outcomes of drug eluting and bare metal stents in saphenous vein graft percutaneous coronary intervention. EuroIntervention. 2011 Mar; 6(8):985-91.

Hamid T, Hadi H, Clarke B, Mahadevan V. The pressure wire as a diagnostic tool in patients with congenital cardiac disease. Cardiol Young. 2011 Jun; 21(3):317-20.

Hamid T, Eichhöfer J, Clarke B, Mahadevan VS. Aortic balloon valvuloplasty: is there still a role in high-risk patients in the era of percutaneous aortic valve replacement? J Interv Cardiol. 2010 Aug; 23(4):358-61.

Mahdi A, Anderson S, Carley S, Mahadevan V. Spotting the complex tachycardia. Emerg Med J. 2010 Mar; 27(3):239-41.

Mamas MA, Clarke B, Mahadevan VS. Percutaneous treatment of dual pulmonary venous drainage and coarctation of the aorta in a single patient. Exp Clin Cardiol. 2010; 15(1):11-3.

Hendry C, Mahadevan V, Fath-Ordoubadi F. Successful percutaneous closure of coronary artery fistula with angiographic follow-up at 6 months. Catheter Cardiovasc Interv. 2009 Mar 01; 73(4):581-3.

Chacko S, Mamas M, Nair S, Luckie M, Hamid T, Mahadevan V. Emergency percutaneous aortic balloon valvuloplasty in a nonagenarian. J Am Geriatr Soc. 2009 Jan; 57(1):185-6.

Mamas MA, Clarke B, Mahadevan VS. Embolisation of systemic-to-pulmonary collaterals in patients with the Eisenmenger reaction presenting with haemoptysis. Cardiol Young. 2008 Oct; 18(5):528-31.

Mahadevan VS, Gomperts N, Haberer K, Silversides C, Benson LN, McLaughlin PR, Horlick EM. Transcatheter closure of atrial septal defects with multiple devices in adults: procedural and clinical outcomes. Int J Cardiol. 2009 Apr 17; 133(3):359-63.

Williams PD, Mahadevan VS, Clarke B. Traumatic aortic dissection and coronary fistula treated with transcatheter management. Catheter Cardiovasc Interv. 2007 Dec 01; 70(7):1013-7.

Lam YY, Kaya MG, Li W, Mahadevan VS, Khan AA, Henein MY, Mullen M. Effect of endovascular stenting of aortic coarctation on biventricular function in adults. Heart. 2007 Nov; 93(11):1441-7.

Mahadevan VS, Jimeno S, Benson LN, McLaughlin PR, Horlick EM. Pre-closure of femoral venous access sites used for large-sized sheath insertion with the Perclose device in adults undergoing cardiac intervention. Heart. 2008 May; 94(5):571-2.

Ali NF, Mahadevan VS, Muir A, Maguire C, Young D, Campalani G, Campbell NP, Danton MH. The influence of prosthesis size and design on exercise dynamics after aortic valve replacement. J Heart Valve Dis. 2006 Nov; 15(6):755-62.

Mahadevan VS, Horlick EM, Benson LN, McLaughlin PR. Transcatheter closure of aortic sinus to left atrial fistula caused by erosion of Amplatzer septal occluder. Catheter Cardiovasc Interv. 2006 Nov; 68(5):749-53.

Appleby C, Clarke B, Keenan D, Mahadevan V. Reversal of supra-systemic pulmonary pressures following mitral valve surgery in a young girl. Int J Cardiol. 2006 Nov 18; 113(3):E113-4.

Collins N, Mahadevan V, Horlick E. Aortic rupture following a covered stent for coarctation: delayed recognition. Catheter Cardiovasc Interv. 2006 Oct; 68(4):653-5.

Mahadevan VS, Campbell M, McKeown PP, Bayraktutan U. Internal mammary artery smooth muscle cells resist migration and possess high antioxidant capacity. Cardiovasc Res. 2006 Oct 01; 72(1):60-8.

Mahadevan VS, Vondermuhll IF, Mullen MJ. Endovascular aortic coarctation stenting in adolescents and adults: angiographic and hemodynamic outcomes. Catheter Cardiovasc Interv. 2006 Feb; 67(2):268-75.

Mahadevan VS, Mullen MJ. Images in cardiovascular medicine. A nest in the chest. Circulation. 2005 Jul 19; 112(3):e45-6.

Mahadevan VS, Earley M, McClements B. Open access echocardiography has diagnostic yield similar to outpatient echocardiography and is highly rated by general practitioners and patients. Int J Cardiol. 2005 Mar 30; 99(3):389-93.

Mahadevan V, Mullen MJ. Endovascular management of aortic coarctation. Int J Cardiol. 2004 Dec; 97 Suppl 1:75-8.

Mahadevan VS, McCarty D, Adgey AA. Platelet GPIIb/IIIa receptor blockers for failed thrombolysis in acute myocardial infarction, alone or as adjunct to other rescue therapies. Eur Heart J. 2002 Oct; 23(19):1490-1.

Mahadevan VS, Ali N, Campalani G, Dalzell GW. Aortic valve fibroelastoma presenting with anginal symptoms in a patient with hypothyroidism. Int J Cardiol. 2002 Jul; 84(1):95-6.

Mahadevan VS, Khan MM, Adgey JA. Clopidogrel as an antiplatelet agent in transplant heart coronary stenting. J Interv Cardiol. 2002 Jun; 15(3):197-9.

Mahadevan VS, Adgey AA. ST depression in ECG at entry indicates severe coronary lesions and large benefits of an early invasive treatment strategy in unstable coronary artery disease--the FRISC II ECG substudy. Fragmin and Fast Revascularisation during Instability in Coronary artery disease. Eur Heart J. 2002 Jan; 23(1):3-5.

Khan MM, Mahadevan VS, Moohan VP, Webb SW. Use of Rtrade mark stent in the percutaneous coronary intervention of coronary bifurcation lesions. Int J Cardiovasc Intervent. 2001 Dec; 4(4):173-180.

Ahmed AA, Mahadevan VS, Webb SW, MacGowan SW. Glue aortoplasty repair of aortic dissection after coronary angioplasty. Ann Thorac Surg. 2001 Sep; 72(3):922-4.

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