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Department of Medicine

Faculty Profiles

R. Sanders Williams, MD

1650 Owens St
San Francisco, CA 94107

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Recent Articles (133)

Williams RS, Lotia S, Holloway AK, Pico AR. From scientific discovery to cures: bright stars within a galaxy. Cell. 2015 Sep 24; 163(1):21-3.

Williams RS, Desmond-Hellmann S. Making translation work. Science. 2011 Jun 17; 332(6036):1359.

Dzau VJ, Ackerly DC, Sutton-Wallace P, Merson MH, Williams RS, Krishnan KR, Taber RC, Califf RM. The role of academic health science systems in the transformation of medicine. Lancet. 2010 Mar 13; 375(9718):949-53.

Yang J, Williams RS, Kelly DP. Bcl3 interacts cooperatively with peroxisome proliferator-activated receptor gamma (PPARgamma) coactivator 1alpha to coactivate nuclear receptors estrogen-related receptor alpha and PPARalpha. Mol Cell Biol. 2009 Aug; 29(15):4091-102.

Jensen EB, Zheng D, Russell RA, Bassel-Duby R, Williams RS, Olson AL, Dohm GL. Regulation of GLUT4 expression in denervated skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2009 Jun; 296(6):R1820-8.

Williams RS. Involvement of academic health centers abroad. Acad Med. 2008 Dec; 83(12):1123; author reply 1123-4.

Stiber J, Hawkins A, Zhang ZS, Wang S, Burch J, Graham V, Ward CC, Seth M, Finch E, Malouf N, Williams RS, Eu JP, Rosenberg P. STIM1 signalling controls store-operated calcium entry required for development and contractile function in skeletal muscle. Nat Cell Biol. 2008 Jun; 10(6):688-97.

Michener JL, Yaggy S, Lyn M, Warburton S, Champagne M, Black M, Cuffe M, Califf R, Gilliss C, Williams RS, Dzau VJ. Improving the health of the community: Duke's experience with community engagement. Acad Med. 2008 Apr; 83(4):408-13.

Stiber JA, Zhang ZS, Burch J, Eu JP, Zhang S, Truskey GA, Seth M, Yamaguchi N, Meissner G, Shah R, Worley PF, Williams RS, Rosenberg PB. Mice lacking Homer 1 exhibit a skeletal myopathy characterized by abnormal transient receptor potential channel activity. Mol Cell Biol. 2008 Apr; 28(8):2637-47.

Williams RS, Casey PJ, Kamei RK, Buckley EG, Soo KC, Merson MH, Krishnan RK, Dzau VJ. A global partnership in medical education between Duke University and the National University of Singapore. Acad Med. 2008 Feb; 83(2):122-7.

Davies KJ, Ermak G, Rothermel BA, Pritchard M, Heitman J, Ahnn J, Henrique-Silva F, Crawford D, Canaider S, Strippoli P, Carinci P, Min KT, Fox DS, Cunningham KW, Bassel-Duby R, Olson EN, Zhang Z, Williams RS, Gerber HP, Pérez-Riba M, Seo H, Cao X, Klee CB, Redondo JM, Maltais LJ, Bruford EA, Povey S, Molkentin JD, McKeon FD, Duh EJ, Crabtree GR, Cyert MS, de la Luna S, Estivill X. Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin. FASEB J. 2007 Oct; 21(12):3023-8.

Meeson AP, Shi X, Alexander MS, Williams RS, Allen RE, Jiang N, Adham IM, Goetsch SC, Hammer RE, Garry DJ. Sox15 and Fhl3 transcriptionally coactivate Foxk1 and regulate myogenic progenitor cells. EMBO J. 2007 Apr 04; 26(7):1902-12.

Li P, Akimoto T, Zhang M, Williams RS, Yan Z. Resident stem cells are not required for exercise-induced fiber-type switching and angiogenesis but are necessary for activity-dependent muscle growth. Am J Physiol Cell Physiol. 2006 Jun; 290(6):C1461-8.

Stiber JA, Tabatabaei N, Hawkins AF, Hawke T, Worley PF, Williams RS, Rosenberg P. Homer modulates NFAT-dependent signaling during muscle differentiation. Dev Biol. 2005 Nov 15; 287(2):213-24.

Akimoto T, Ushida T, Miyaki S, Akaogi H, Tsuchiya K, Yan Z, Williams RS, Tateishi T. Mechanical stretch inhibits myoblast-to-adipocyte differentiation through Wnt signaling. Biochem Biophys Res Commun. 2005 Apr 01; 329(1):381-5.

Williams RS, Kraus WE. Exercise and health: can biotechnology confer similar benefits? PLoS Med. 2005 Mar; 2(3):e68.

Akimoto T, Pohnert SC, Li P, Zhang M, Gumbs C, Rosenberg PB, Williams RS, Yan Z. Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway. J Biol Chem. 2005 May 20; 280(20):19587-93.

Williams RS, Annex BH. Plasticity of myocytes and capillaries: a possible coordinating role for VEGF. Circ Res. 2004 Jul 09; 95(1):7-8.

Masino AM, Gallardo TD, Wilcox CA, Olson EN, Williams RS, Garry DJ. Transcriptional regulation of cardiac progenitor cell populations. Circ Res. 2004 Aug 20; 95(4):389-97.

Akimoto T, Ribar TJ, Williams RS, Yan Z. Skeletal muscle adaptation in response to voluntary running in Ca2+/calmodulin-dependent protein kinase IV-deficient mice. Am J Physiol Cell Physiol. 2004 Nov; 287(5):C1311-9.

Rosenberg P, Hawkins A, Stiber J, Shelton JM, Hutcheson K, Bassel-Duby R, Shin DM, Yan Z, Williams RS. TRPC3 channels confer cellular memory of recent neuromuscular activity. Proc Natl Acad Sci U S A. 2004 Jun 22; 101(25):9387-92.

Cronin EM, Thurmond FA, Bassel-Duby R, Williams RS, Wright WE, Nelson KD, Garner HR. Protein-coated poly(L-lactic acid) fibers provide a substrate for differentiation of human skeletal muscle cells. J Biomed Mater Res A. 2004 Jun 01; 69(3):373-81.

van Rooij E, Doevendans PA, Crijns HJ, Heeneman S, Lips DJ, van Bilsen M, Williams RS, Olson EN, Bassel-Duby R, Rothermel BA, De Windt LJ. MCIP1 overexpression suppresses left ventricular remodeling and sustains cardiac function after myocardial infarction. Circ Res. 2004 Feb 20; 94(3):e18-26.

Rybkin II, Markham DW, Yan Z, Bassel-Duby R, Williams RS, Olson EN. Conditional expression of SV40 T-antigen in mouse cardiomyocytes facilitates an inducible switch from proliferation to differentiation. J Biol Chem. 2003 May 02; 278(18):15927-34.

Chin ER, Grange RW, Viau F, Simard AR, Humphries C, Shelton J, Bassel-Duby R, Williams RS, Michel RN. Alterations in slow-twitch muscle phenotype in transgenic mice overexpressing the Ca2+ buffering protein parvalbumin. J Physiol. 2003 Mar 01; 547(Pt 2):649-63.

Vega RB, Rothermel BA, Weinheimer CJ, Kovacs A, Naseem RH, Bassel-Duby R, Williams RS, Olson EN. Dual roles of modulatory calcineurin-interacting protein 1 in cardiac hypertrophy. Proc Natl Acad Sci U S A. 2003 Jan 21; 100(2):669-74.

Wu H, Gallardo T, Olson EN, Williams RS, Shohet RV. Transcriptional analysis of mouse skeletal myofiber diversity and adaptation to endurance exercise. J Muscle Res Cell Motil. 2003; 24(8):587-92.

Yan Z, Choi S, Liu X, Zhang M, Schageman JJ, Lee SY, Hart R, Lin L, Thurmond FA, Williams RS. Highly coordinated gene regulation in mouse skeletal muscle regeneration. J Biol Chem. 2003 Mar 07; 278(10):8826-36.

Vega RB, Yang J, Rothermel BA, Bassel-Duby R, Williams RS. Multiple domains of MCIP1 contribute to inhibition of calcineurin activity. J Biol Chem. 2002 Aug 16; 277(33):30401-7.

Wu H, Kanatous SB, Thurmond FA, Gallardo T, Isotani E, Bassel-Duby R, Williams RS. Regulation of mitochondrial biogenesis in skeletal muscle by CaMK. Science. 2002 Apr 12; 296(5566):349-52.

Hill JA, Rothermel B, Yoo KD, Cabuay B, Demetroulis E, Weiss RM, Kutschke W, Bassel-Duby R, Williams RS. Targeted inhibition of calcineurin in pressure-overload cardiac hypertrophy. Preservation of systolic function. J Biol Chem. 2002 Mar 22; 277(12):10251-5.

Wu H, Rothermel B, Kanatous S, Rosenberg P, Naya FJ, Shelton JM, Hutcheson KA, DiMaio JM, Olson EN, Bassel-Duby R, Williams RS. Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway. EMBO J. 2001 Nov 15; 20(22):6414-23.

Grange RW, Meeson A, Chin E, Lau KS, Stull JT, Shelton JM, Williams RS, Garry DJ. Functional and molecular adaptations in skeletal muscle of myoglobin-mutant mice. Am J Physiol Cell Physiol. 2001 Nov; 281(5):C1487-94.

Dunn SE, Simard AR, Bassel-Duby R, Williams RS, Michel RN. Nerve activity-dependent modulation of calcineurin signaling in adult fast and slow skeletal muscle fibers. J Biol Chem. 2001 Nov 30; 276(48):45243-54.

Kong Y, Shelton JM, Rothermel B, Li X, Richardson JA, Bassel-Duby R, Williams RS. Cardiac-specific LIM protein FHL2 modifies the hypertrophic response to beta-adrenergic stimulation. Circulation. 2001 Jun 05; 103(22):2731-8.

Meeson AP, Radford N, Shelton JM, Mammen PP, DiMaio JM, Hutcheson K, Kong Y, Elterman J, Williams RS, Garry DJ. Adaptive mechanisms that preserve cardiac function in mice without myoglobin. Circ Res. 2001 Apr 13; 88(7):713-20.

Rothermel BA, McKinsey TA, Vega RB, Nicol RL, Mammen P, Yang J, Antos CL, Shelton JM, Bassel-Duby R, Olson EN, Williams RS. Myocyte-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo. Proc Natl Acad Sci U S A. 2001 Mar 13; 98(6):3328-33.

Yan Z, Serrano AL, Schiaffino S, Bassel-Duby R, Williams RS. Regulatory elements governing transcription in specialized myofiber subtypes. J Biol Chem. 2001 May 18; 276(20):17361-6.

Yang J, Rothermel B, Vega RB, Frey N, McKinsey TA, Olson EN, Bassel-Duby R, Williams RS. Independent signals control expression of the calcineurin inhibitory proteins MCIP1 and MCIP2 in striated muscles. Circ Res. 2000 Dec 08; 87(12):E61-8.

Zhu W, Williams RS, Kodadek T. A CDC6 protein-binding peptide selected using a bacterial two-hybrid-like system is a cell cycle inhibitor. J Biol Chem. 2000 Oct 13; 275(41):32098-105.

Wren JD, Forgacs E, Fondon JW, Pertsemlidis A, Cheng SY, Gallardo T, Williams RS, Shohet RV, Minna JD, Garner HR. Repeat polymorphisms within gene regions: phenotypic and evolutionary implications. Am J Hum Genet. 2000 Aug; 67(2):345-56.

Li K, Li Y, Shelton JM, Richardson JA, Spencer E, Chen ZJ, Wang X, Williams RS. Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis. Cell. 2000 May 12; 101(4):389-99.

Garry DJ, Meeson A, Elterman J, Zhao Y, Yang P, Bassel-Duby R, Williams RS. Myogenic stem cell function is impaired in mice lacking the forkhead/winged helix protein MNF. Proc Natl Acad Sci U S A. 2000 May 09; 97(10):5416-21.

Wu H, Naya FJ, McKinsey TA, Mercer B, Shelton JM, Chin ER, Simard AR, Michel RN, Bassel-Duby R, Olson EN, Williams RS. MEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber type. EMBO J. 2000 May 02; 19(9):1963-73.

Rothermel B, Vega RB, Yang J, Wu H, Bassel-Duby R, Williams RS. A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling. J Biol Chem. 2000 Mar 24; 275(12):8719-25.

Naya FJ, Mercer B, Shelton J, Richardson JA, Williams RS, Olson EN. Stimulation of slow skeletal muscle fiber gene expression by calcineurin in vivo. J Biol Chem. 2000 Feb 18; 275(7):4545-8.

Yan Z, Fedorov SA, Mumby MC, Williams RS. PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells. Mol Cell Biol. 2000 Feb; 20(3):1021-9.

Xia Y, McMillin JB, Lewis A, Moore M, Zhu WG, Williams RS, Kellems RE. Electrical stimulation of neonatal cardiac myocytes activates the NFAT3 and GATA4 pathways and up-regulates the adenylosuccinate synthetase 1 gene. J Biol Chem. 2000 Jan 21; 275(3):1855-63.

Yang Q, Kong Y, Rothermel B, Garry DJ, Bassel-Duby R, Williams RS. The winged-helix/forkhead protein myocyte nuclear factor beta (MNF-beta) forms a co-repressor complex with mammalian sin3B. Biochem J. 2000 Jan 15; 345 Pt 2:335-43.

Garry DJ, Ordway GA, Lorenz JN, Radford NB, Chin ER, Grange RW, Bassel-Duby R, Williams RS. Mice without myoglobin. Nature. 1998 Oct 29; 395(6705):905-8.

Grayson J, Bassel-Duby R, Williams RS. Collaborative interactions between MEF-2 and Sp1 in muscle-specific gene regulation. J Cell Biochem. 1998 Sep 01; 70(3):366-75.

Chin ER, Olson EN, Richardson JA, Yang Q, Humphries C, Shelton JM, Wu H, Zhu W, Bassel-Duby R, Williams RS. A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type. Genes Dev. 1998 Aug 15; 12(16):2499-509.

Leone G, DeGregori J, Yan Z, Jakoi L, Ishida S, Williams RS, Nevins JR. E2F3 activity is regulated during the cell cycle and is required for the induction of S phase. Genes Dev. 1998 Jul 15; 12(14):2120-30.

Yan Z, DeGregori J, Shohet R, Leone G, Stillman B, Nevins JR, Williams RS. Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells. Proc Natl Acad Sci U S A. 1998 Mar 31; 95(7):3603-8.

Schultz RA, Swoap SJ, McDaniel LD, Zhang B, Koon EC, Garry DJ, Li K, Williams RS. Differential expression of mitochondrial DNA replication factors in mammalian tissues. J Biol Chem. 1998 Feb 06; 273(6):3447-51.

Neufer PD, Ordway GA, Williams RS. Transient regulation of c-fos, alpha B-crystallin, and hsp70 in muscle during recovery from contractile activity. Am J Physiol. 1998 Feb; 274(2 Pt 1):C341-6.

Yang Q, Bassel-Duby R, Williams RS. Transient expression of a winged-helix protein, MNF-beta, during myogenesis. Mol Cell Biol. 1997 Sep; 17(9):5236-43.

Garry DJ, Yang Q, Bassel-Duby R, Williams RS. Persistent expression of MNF identifies myogenic stem cells in postnatal muscles. Dev Biol. 1997 Aug 15; 188(2):280-94.

Li K, Williams RS. Tetramerization and single-stranded DNA binding properties of native and mutated forms of murine mitochondrial single-stranded DNA-binding proteins. J Biol Chem. 1997 Mar 28; 272(13):8686-94.

Williams RS, Shohet RV, Stillman B. A human protein related to yeast Cdc6p. Proc Natl Acad Sci U S A. 1997 Jan 07; 94(1):142-7.

Neufer PD, Ordway GA, Hand GA, Shelton JM, Richardson JA, Benjamin IJ, Williams RS. Continuous contractile activity induces fiber type specific expression of HSP70 in skeletal muscle. Am J Physiol. 1996 Dec; 271(6 Pt 1):C1828-37.

Radford NB, Fina M, Benjamin IJ, Moreadith RW, Graves KH, Zhao P, Gavva S, Wiethoff A, Sherry AD, Malloy CR, Williams RS. Cardioprotective effects of 70-kDa heat shock protein in transgenic mice. Proc Natl Acad Sci U S A. 1996 Mar 19; 93(6):2339-42.

Parsons WJ, Williams RS, Shelton JM, Luo Y, Kessler DJ, Richardson JA. Developmental regulation of cytochrome oxidase subunit VIa isoforms in cardiac and skeletal muscle. Am J Physiol. 1996 Feb; 270(2 Pt 2):H567-74.

Garry DJ, Bassel-Duby RS, Richardson JA, Grayson J, Neufer PD, Williams RS. Postnatal development and plasticity of specialized muscle fiber characteristics in the hindlimb. Dev Genet. 1996; 19(2):146-56.

Li K, Neufer PD, Williams RS. Nuclear responses to depletion of mitochondrial DNA in human cells. Am J Physiol. 1995 Nov; 269(5 Pt 1):C1265-70.

Wilson LB, Dyke CK, Parsons D, Wall PT, Pawelczyk JA, Williams RS, Mitchell JH. Effect of skeletal muscle fiber type on the pressor response evoked by static contraction in rabbits. J Appl Physiol (1985). 1995 Nov; 79(5):1744-52.

Li K, Williams RS. Cloning and characterization of three new murine genes encoding short homologues of RNase P RNA. J Biol Chem. 1995 Oct 20; 270(42):25281-5.

Grayson J, Williams RS, Yu YT, Bassel-Duby R. Synergistic interactions between heterologous upstream activation elements and specific TATA sequences in a muscle-specific promoter. Mol Cell Biol. 1995 Apr; 15(4):1870-8.

Bassel-Duby R, Hernandez MD, Yang Q, Rochelle JM, Seldin MF, Williams RS. Myocyte nuclear factor, a novel winged-helix transcription factor under both developmental and neural regulation in striated myocytes. Mol Cell Biol. 1994 Jul; 14(7):4596-605.

Michel JB, Ordway GA, Richardson JA, Williams RS. Biphasic induction of immediate early gene expression accompanies activity-dependent angiogenesis and myofiber remodeling of rabbit skeletal muscle. J Clin Invest. 1994 Jul; 94(1):277-85.

Li K, Smagula CS, Parsons WJ, Richardson JA, Gonzalez M, Hagler HK, Williams RS. Subcellular partitioning of MRP RNA assessed by ultrastructural and biochemical analysis. J Cell Biol. 1994 Mar; 124(6):871-82.

Ordway GA, Li K, Hand GA, Williams RS. RNA subunit of mitochondrial RNA-processing enzyme is induced by contractile activity in striated muscle. Am J Physiol. 1993 Dec; 265(6 Pt 1):C1511-6.

Neyses L, Nouskas J, Luyken J, Fronhoffs S, Oberdorf S, Pfeifer U, Williams RS, Sukhatme VP, Vetter H. Induction of immediate-early genes by angiotensin II and endothelin-1 in adult rat cardiomyocytes. J Hypertens. 1993 Sep; 11(9):927-34.

Bassel-Duby R, Grohe CM, Jessen ME, Parsons WJ, Richardson JA, Chao R, Grayson J, Ring WS, Williams RS. Sequence elements required for transcriptional activity of the human myoglobin promoter in intact myocardium. Circ Res. 1993 Aug; 73(2):360-6.

Williams RS, Thomas JA, Fina M, German Z, Benjamin IJ. Human heat shock protein 70 (hsp70) protects murine cells from injury during metabolic stress. J Clin Invest. 1993 Jul; 92(1):503-8.

Parsons WJ, Richardson JA, Graves KH, Williams RS, Moreadith RW. Gradients of transgene expression directed by the human myoglobin promoter in the developing mouse heart. Proc Natl Acad Sci U S A. 1993 Mar 01; 90(5):1726-30.

Bassel-Duby R, Hernandez MD, Gonzalez MA, Krueger JK, Williams RS. A 40-kilodalton protein binds specifically to an upstream sequence element essential for muscle-specific transcription of the human myoglobin promoter. Mol Cell Biol. 1992 Nov; 12(11):5024-32.

Mao ZF. [Surgical treatment of abnormal myocardial bundle in the right ventricle]. Zhonghua Xin Xue Guan Bing Za Zhi. 1992 Aug; 20(4):230-1, 260.

Benjamin IJ, Horie S, Greenberg ML, Alpern RJ, Williams RS. Induction of stress proteins in cultured myogenic cells. Molecular signals for the activation of heat shock transcription factor during ischemia. J Clin Invest. 1992 May; 89(5):1685-9.

Williams RS, Johnston SA, Riedy M, DeVit MJ, McElligott SG, Sanford JC. Introduction of foreign genes into tissues of living mice by DNA-coated microprojectiles. Proc Natl Acad Sci U S A. 1991 Apr 01; 88(7):2726-30.

Annex BH, Kraus WE, Dohm GL, Williams RS. Mitochondrial biogenesis in striated muscles: rapid induction of citrate synthase mRNA by nerve stimulation. Am J Physiol. 1991 Feb; 260(2 Pt 1):C266-70.

Annex BH, Williams RS. Mitochondrial DNA structure and expression in specialized subtypes of mammalian striated muscle. Mol Cell Biol. 1990 Nov; 10(11):5671-8.

Benjamin IJ, Kröger B, Williams RS. Activation of the heat shock transcription factor by hypoxia in mammalian cells. Proc Natl Acad Sci U S A. 1990 Aug; 87(16):6263-7.

Williams RS. Genetic mechanisms that determine oxidative capacity of striated muscles. Control of gene transcription. Circulation. 1990 Aug; 82(2):319-31.

Morrow NG, Kraus WE, Moore JW, Williams RS, Swain JL. Increased expression of fibroblast growth factors in a rabbit skeletal muscle model of exercise conditioning. J Clin Invest. 1990 Jun; 85(6):1816-20.

Wefald FC, Devlin BH, Williams RS. Functional heterogeneity of mammalian TATA-box sequences revealed by interaction with a cell-specific enhancer. Nature. 1990 Mar 15; 344(6263):260-2.

Devlin BH, Wefald FC, Kraus WE, Bernard TS, Williams RS. Identification of a muscle-specific enhancer within the 5'-flanking region of the human myoglobin gene. J Biol Chem. 1989 Aug 15; 264(23):13896-901.

Kraus WE, Bernard TS, Williams RS. Interactions between sustained contractile activity and beta-adrenergic receptors in regulation of gene expression in skeletal muscles. Am J Physiol. 1989 Mar; 256(3 Pt 1):C506-14.

Schachat F, Williams RS, Schnurr CA. Coordinate changes in fast thin filament and Z-line protein expression in the early response to chronic stimulation. J Biol Chem. 1988 Oct 05; 263(28):13975-8.

Harlan WR, Williams RS. Activity-induced adaptations in skeletal muscles of iron-deficient rabbits. J Appl Physiol (1985). 1988 Aug; 65(2):782-7.

Blumenthal JA, Emery CF, Walsh MA, Cox DR, Kuhn CM, Williams RB, Williams RS. Exercise training in healthy type A middle-aged men: effects on behavioral and cardiovascular responses. Psychosom Med. 1988 Jul-Aug; 50(4):418-33.

Blumenthal JA, Rejeski WJ, Walsh-Riddle M, Emery CF, Miller H, Roark S, Ribisl PM, Morris PB, Brubaker P, Williams RS. Comparison of high- and low-intensity exercise training early after acute myocardial infarction. Am J Cardiol. 1988 Jan 01; 61(1):26-30.

Williams RS, Harlan W. Effects of inhibition of mitochondrial protein synthesis in skeletal muscle. Am J Physiol. 1987 Dec; 253(6 Pt 1):C866-71.

Underwood LE, Williams RS. Pretranslational regulation of myoglobin gene expression. Am J Physiol. 1987 Apr; 252(4 Pt 1):C450-3.

Friedman DB, Ordway GA, Williams RS. Exercise-induced functional desensitization of canine cardiac beta-adrenergic receptors. J Appl Physiol (1985). 1987 Apr; 62(4):1721-3.

Williams RS, Garcia-Moll M, Mellor J, Salmons S, Harlan W. Adaptation of skeletal muscle to increased contractile activity. Expression nuclear genes encoding mitochondrial proteins. J Biol Chem. 1987 Feb 25; 262(6):2764-7.

Friedman DB, Musch TI, Williams RS, Ordway GA. Beta adrenergic blockade with propranolol and atenolol in the exercising dog: evidence for beta 2 adrenoceptors in the sinoatrial node. Cardiovasc Res. 1987 Feb; 21(2):124-9.

Williams RS. Mitochondrial gene expression in mammalian striated muscle. Evidence that variation in gene dosage is the major regulatory event. J Biol Chem. 1986 Sep 15; 261(26):12390-4.

Schaffer W, Williams RS. Age-dependent changes in expression of alpha 1-adrenergic receptors in rat myocardium. Biochem Biophys Res Commun. 1986 Jul 16; 138(1):387-91.

Higginbotham MB, Morris KG, Williams RS, Coleman RE, Cobb FR. Physiologic basis for the age-related decline in aerobic work capacity. Am J Cardiol. 1986 Jun 01; 57(15):1374-9.

Higginbotham MB, Morris KG, Williams RS, McHale PA, Coleman RE, Cobb FR. Regulation of stroke volume during submaximal and maximal upright exercise in normal man. Circ Res. 1986 Feb; 58(2):281-91.

Williams RS, Salmons S, Newsholme EA, Kaufman RE, Mellor J. Regulation of nuclear and mitochondrial gene expression by contractile activity in skeletal muscle. J Biol Chem. 1986 Jan 05; 261(1):376-80.

McLeod AA, Knopes KD, Shand DG, Williams RS. Beta 1-selective and non-selective beta-adrenoceptor blockade, anaerobic threshold and respiratory gas exchange during exercise. Br J Clin Pharmacol. 1985 Jan; 19(1):13-20.

Adragna NC, Chang JL, Morey MC, Williams RS. Effect of exercise on cation transport in human red cells. Hypertension. 1985 Jan-Feb; 7(1):132-9.

Williams RS, McKinnis RA, Cobb FR, Higginbotham MB, Wallace AG, Coleman RE, Califf RM. Effects of physical conditioning on left ventricular ejection fraction in patients with coronary artery disease. Circulation. 1984 Jul; 70(1):69-75.

McLeod AA, Kraus WE, Williams RS. Effects of beta 1-selective and nonselective beta-adrenoceptor blockade during exercise conditioning in healthy adults. Am J Cardiol. 1984 Jun 01; 53(11):1656-61.

Shalom R, Blumenthal JA, Williams RS, McMurray RG, Dennis VW. Feasibility and benefits of exercise training in patients on maintenance dialysis. Kidney Int. 1984 Jun; 25(6):958-63.

Williams RS, Schaible TF, Bishop T, Morey M. Effects of endurance training on cholinergic and adrenergic receptors of rat heart. J Mol Cell Cardiol. 1984 May; 16(5):395-403.

McLeod AA, Brown JE, Kitchell BB, Sedor FA, Kuhn DC, Williams RS, Shand DG. Hemodynamic and metabolic responses to exercise after alpha 1-, beta 1-, and nonselective beta-adrenoceptor blockade in man. Am J Med. 1984 Feb 27; 76(2A):97-100.

Williams RS, Caron MG, Daniel K. Skeletal muscle beta-adrenergic receptors: variations due to fiber type and training. Am J Physiol. 1984 Feb; 246(2 Pt 1):E160-7.

Williams RS, Schaible TF, Scheuer J, Kennedy R. Effects of experimental diabetes on adrenergic and cholinergic receptors of rat myocardium. Diabetes. 1983 Oct; 32(10):881-6.

McLeod AA, Brown JE, Kuhn C, Kitchell BB, Sedor FA, Williams RS, Shand DG. Differentiation of hemodynamic, humoral and metabolic responses to beta 1- and beta 2-adrenergic stimulation in man using atenolol and propranolol. Circulation. 1983 May; 67(5):1076-84.

Williams RS. Selectivity of prenalterol for adrenergic receptor subtypes: a potential mechanism of inotropic selectivity. J Cardiovasc Pharmacol. 1983 Mar-Apr; 5(2):266-71.

Kopitsky RG, Switzer ME, Williams RS, McKee PA. The basis for the increase in factor VIII procoagulant activity during exercise. Thromb Haemost. 1983 Feb 28; 49(1):53-7.

Blumenthal JA, Williams RS, Needels TL, Wallace AG. Psychological changes accompany aerobic exercise in healthy middle-aged adults. Psychosom Med. 1982 Dec; 44(6):529-36.

Blumenthal JA, Williams RS, Wallace AG, Williams RB, Needles TL. Physiological and psychological variables predict compliance to prescribed exercise therapy in patients recovering from myocardial infarction. Psychosom Med. 1982 Dec; 44(6):519-27.

Williams RS, Bishop T. Enhanced receptor-cyclase coupling and augmented catecholamine-stimulated lipolysis in exercising rats. Am J Physiol. 1982 Nov; 243(5):E345-51.

Cobb FR, Williams RS, McEwan P, Jones RH, Coleman RE, Wallace AG. Effects of exercise training on ventricular function in patients with recent myocardial infarction. Circulation. 1982 Jul; 66(1):100-8.

Conn EH, Williams RS, Wallace AG. Exercise responses before and after physical conditioning in patients with severely depressed left ventricular function. Am J Cardiol. 1982 Feb 01; 49(2):296-300.

Williams RS, Eden RS, Moll ME, Lester RM, Wallace AG. Autonomic mechanisms of training bradycardia: beta-adrenergic receptors in humans. J Appl Physiol Respir Environ Exerc Physiol. 1981 Nov; 51(5):1232-7.

Williams RS, Bishop T. Selectivity of dobutamine for adrenergic receptor subtypes: in vitro analysis by radioligand binding. J Clin Invest. 1981 Jun; 67(6):1703-11.

Williams RS, Dukes DF, Lefkowitz RJ. Subtype specificity of alpha-adrenergic receptors in rat heart. J Cardiovasc Pharmacol. 1981 May-Jun; 3(3):522-31.

Williams RS, Bashore TM. Paroxysmal hypotension associated with sympathetic withdrawal. A new disorder of autonomic vasomotor regulation. Circulation. 1980 Oct; 62(4):901-8.

Williams RS, Logue EE, Lewis JG, Barton T, Stead NW, Wallace AG, Pizzo SV. Physical conditioning augments the fibrinolytic response to venous occlusion in healthy adults. N Engl J Med. 1980 May 01; 302(18):987-91.

Blumenthal JA, Williams RS, Williams RB, Wallace AG. Effects of exercise on the Type A (coronary prone) behavior pattern. Psychosom Med. 1980 Mar; 42(2):289-96.

Williams RS. Physical conditioning and membrane receptors for cardioregulatory hormones. Cardiovasc Res. 1980 Mar; 14(3):177-82.

Williams RS, Behar VS, Peter RH. Left bundle branch block: angiographic segmental wall motion abnormalities. Am J Cardiol. 1979 Nov; 44(6):1046-9.

Moll ME, Williams RS, Lester RM, Quarfordt SH, Wallace AG. Cholesterol metabolism in non-obese women--Failure of physical conditioning to alter levels of high density lipoprotein cholesterol. Atherosclerosis. 1979 Oct; 34(2):159-66.

Williams RS, Lefkowitz RJ. Thyroid hormone regulation of alpha-adrenergic receptors: studies in rat myocardium. J Cardiovasc Pharmacol. 1979 Mar-Apr; 1(2):181-9.

Williams RS, Guthrow CE, Lefkowitz RJ. Beta-Adrenergic receptors of human lymphocytes are unaltered by hyperthyroidism. J Clin Endocrinol Metab. 1979 Mar; 48(3):503-5.

Jarboe CH, Lipson SF, Bannon MJ, Dunnigan DA. 2,5-Bis(3,4-dimethoxybenzyl)cyclopentylamine, a peripheral dopamine blocking agent. J Med Chem. 1978 Dec; 21(12):1318-20.

Williams RS, Lefkowitz RJ. Alpha-adrenergic receptors in rat myocardium. Identification by binding of [3H]dihydroergocryptine. Circ Res. 1978 Nov; 43(5):721-7.

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