Faculty ProfilesMichael Dae, MD
185 Berry Street
San Francisco, CA 94143
Michael Dae, MD, is a Professor in Residence in Nuclear Medicine Section at the University of California, San Francisco. Dr. Dae obtained his medical degree in Medicine from Duke University in Durham, North Carolina in 1976, and completed his residency in Pediatrics at the Children's Hospital in Boston, Massachusetts in 1978, followed by a fellowship in Pediatric Cardiology and Nuclear Cardiology from UCSF. Currently, he leads an initiative to increase clinical utilization of cardiac positron emission tomographic imaging (PET) for patients to provide better diagnostic imaging with less radiation exposure, and greater patient experience.
As a research focus, Dr. Dae and his colleagues have developed extensive experience with radionuclide assessment of myocardial sympathetic innervation. They evaluate the ability of MIBG to map sympathetic innervation in various experimental models of cardiac disease, and have characterized the physiologic and electro physiologic consequences of abdominal uptake and distribution of the tracer. Also, Dr. Dae and his colleagues have extensive experience in the pre-clinical and clinical assessment of new medical devices in cardiovascular medicine, ranging from assessment of prototypes to the completion of GLP studies for FDA submissions.
Dr. Dae has published and written 93 articles, 27 book chapters, and 6 significant publications. He is responsible for conceiving studies, assisting with trail designs, supervising performances, and designing imaging aspects of the experiments.
Development of a noninvasive approach to treat acute and chronic kidney disease
Education and Training:
• Medical School: Duke University, Durham, North Carolina - Medicine
• Internship: Children's Hospital, Boston, Massachusetts - Pediatrics
• Residency: Children's Hospital, Boston, Massachusetts - Pediatrics
• Residency: University of California, San Francisco - Nuclear Medicine, Chief Resident
• Fellowship: University of California, San Francisco - Pediatric Cardiology
• Fellowship: University of California, San Francisco - Nuclear Cardiology
• Master of Business Administration: University of San Francisco - Business
• Diplomate, National Board of Medical Examiners
• California License
• American Board of Pediatrics
• American Board of Nuclear Medicine
• Certified - Advanced Cardiac Life Support
• Certified - Basic Life Support
• Level 2 Certification for Competency in Cardiac CT
• Certificate of Proficiency - PET/CT - American College of Radiology
• Certified - Advanced Cardiac Life Support
Education and Training
|Location||Degree or Training||Specialty||Date|
|Duke University||M.D.||School of Medicine||1976|
|University of California, San Francisco||Residency||School of Medicine|
|University of California, San Francisco||Clinical Fellowship||Radiology|
Development of a non-invasive approach to treat acute and chronic kidney disease.Awards and Honors
Fellow Award, American College of Cardiology, 2003
Cardiovascular Diseases, Nuclear Medicine, Best Doctors in America, 2003
First Award, NIH, 1988-1993
Pre-Tenure Award, niversity of California, San Francisco, 1988
Academic Senate Faculty Development Award, University of California, San Francisco, 1987
Research Training Grant, PHS, 1978
Related Web Sites
|Project Title||Project Number||Fiscal Year|
Mateos-Pérez JM, Desco M, Dae MW, García-Villalba C, Cussó L, Vaquero JJ. Automatic TAC extraction from dynamic cardiac PET imaging using iterative correlation from a population template. Comput Methods Programs Biomed. 2013 Aug; 111(2):308-14.
Vaquero JJ, Gao DW, García-Villaba C, Bacharach S, Vanbrocklin H, Fang Q, Desco M, Lee R, Dae M. Approach to assessing myocardial perfusion in rats using static [13N]-ammonia images and a small-animal PET. Mol Imaging Biol. 2012 Oct; 14(5):541-5.
Mihardja SS, Gao D, Sievers RE, Fang Q, Feng J, Wang J, Vanbrocklin HF, Larrick JW, Huang M, Dae M, Lee RJ. Targeted in vivo extracellular matrix formation promotes neovascularization in a rodent model of myocardial infarction. PLoS One. 2010; 5(4):e10384.
Nikolic SD, Khairkhahan A, Ryu M, Champsaur G, Breznock E, Dae M. Percutaneous implantation of an intraventricular device for the treatment of heart failure: experimental results and proof of concept. J Card Fail. 2009 Nov; 15(9):790-7.
del Romeral LM, Stillson C, Lesh M, Dae M, Botvinick E. The relationship of myocardial contraction and electrical excitation--the correlation between scintigraphic phase image analysis and electrophysiologic mapping. J Nucl Cardiol. 2009 Sep-Oct; 16(5):792-800.
Botvinick E, Davis J, Dae M, O'Connell J, Schechtmann N, Abbott J, Morady F, Lanzer P, Iskikian J, Scheinman M. Localization of ventricular tachycardia exit site and subsequent contraction sequence and functional effects with bedside radionuclide angiography. JACC Cardiovasc Imaging. 2008 Sep; 1(5):605-13.
Banki N, Kopelnik A, Tung P, Lawton MT, Gress D, Drew B, Dae M, Foster E, Parmley W, Zaroff J. Prospective analysis of prevalence, distribution, and rate of recovery of left ventricular systolic dysfunction in patients with subarachnoid hemorrhage. J Neurosurg. 2006 Jul; 105(1):15-20.
Banki NM, Kopelnik A, Dae MW, Miss J, Tung P, Lawton MT, Drew BJ, Foster E, Smith W, Parmley WW, Zaroff JG. Acute neurocardiogenic injury after subarachnoid hemorrhage. Circulation. 2005 Nov 22; 112(21):3314-9.
Khush K, Kopelnik A, Tung P, Banki N, Dae M, Lawton M, Smith W, Drew B, Foster E, Zaroff J. Age and aneurysm position predict patterns of left ventricular dysfunction after subarachnoid hemorrhage. J Am Soc Echocardiogr. 2005 Feb; 18(2):168-74.
Frelinger AL, Furman MI, Barnard MR, Krueger LA, Dae MW, Michelson AD. Combined effects of mild hypothermia and glycoprotein IIb/IIIa antagonists on platelet-platelet and leukocyte-platelet aggregation. Am J Cardiol. 2003 Nov 1; 92(9):1099-101.
Dae MW, Gao DW, Ursell PC, Stillson CA, Sessler DI. Safety and efficacy of endovascular cooling and rewarming for induction and reversal of hypothermia in human-sized pigs. Stroke. 2003 Mar; 34(3):734-8.
Dixon SR, Whitbourn RJ, Dae MW, Grube E, Sherman W, Schaer GL, Jenkins JS, Baim DS, Gibbons RJ, Kuntz RE, Popma JJ, Nguyen TT, O'Neill WW. Induction of mild systemic hypothermia with endovascular cooling during primary percutaneous coronary intervention for acute myocardial infarction. J Am Coll Cardiol. 2002 Dec 4; 40(11):1928-34.
Dae MW, Gao DW, Sessler DI, Chair K, Stillson CA. Effect of endovascular cooling on myocardial temperature, infarct size, and cardiac output in human-sized pigs. Am J Physiol Heart Circ Physiol. 2002 May; 282(5):H1584-91.
Mokhtarani M, Mahgoub AN, Morioka N, Doufas AG, Dae M, Shaughnessy TE, Bjorksten AR, Sessler DI. Buspirone and meperidine synergistically reduce the shivering threshold. Anesth Analg. 2001 Nov; 93(5):1233-9.
Da Silva AJ, Tang HR, Wong KH, Wu MC, Dae MW, Hasegawa BH. Absolute quantification of regional myocardial uptake of 99mTc-sestamibi with SPECT: experimental validation in a porcine model. J Nucl Med. 2001 May; 42(5):772-9.
Arheden H, Saeed M, Higgins CB, Gao DW, Ursell PC, Bremerich J, Wyttenbach R, Dae MW, Wendland MF. Reperfused rat myocardium subjected to various durations of ischemia: estimation of the distribution volume of contrast material with echo-planar MR imaging. Radiology. 2000 May; 215(2):520-8.
Redberg RF, Nishino M, McElhinney DB, Dae MW, Botvinick EH. Long-term estrogen replacement therapy is associated with improved exercise capacity in postmenopausal women without known coronary artery disease. Am Heart J. 2000 Apr; 139(4):739-44.
Yoshioka K, Gao DW, Chin M, Stillson C, Penades E, Lesh M, O'Connell W, Dae M. Heterogeneous sympathetic innervation influences local myocardial repolarization in normally perfused rabbit hearts. Circulation. 2000 Mar 7; 101(9):1060-6.
Oka RK, De Marco T, Haskell WL, Botvinick E, Dae MW, Bolen K, Chatterjee K. Impact of a home-based walking and resistance training program on quality of life in patients with heart failure. Am J Cardiol. 2000 Feb 1; 85(3):365-9.
Arheden H, Saeed M, Higgins CB, Gao DW, Bremerich J, Wyttenbach R, Dae MW, Wendland MF. Measurement of the distribution volume of gadopentetate dimeglumine at echo-planar MR imaging to quantify myocardial infarction: comparison with 99mTc-DTPA autoradiography in rats. Radiology. 1999 Jun; 211(3):698-708.
Bremerich J, Wendland MF, Arheden H, Wyttenbach R, Gao DW, Huberty JP, Dae MW, Higgins CB, Saeed M. Microvascular injury in reperfused infarcted myocardium: noninvasive assessment with contrast-enhanced echoplanar magnetic resonance imaging. J Am Coll Cardiol. 1998 Sep; 32(3):787-93.
Bobba K, Botvinick EH, Sciammarella MG, Starsken NF, Zhu YY, Lapidus A, Dae MW. Is there any advantage to the acquisition of 24-hour thallium images, in the presence of persistent perfusion defects at 4 h after reinjection? Eur J Nucl Med. 1998 May; 25(5):509-14.
Botvinick EH, O'Connell JW, Kadkade PP, Glickman SL, Dae MW, Cohen TJ, Abbott J, Krishnan R. Potential added value of three-dimensional reconstruction and display of single photon emission computed tomographic gated blood pool images. J Nucl Cardiol. 1998 May-Jun; 5(3):245-55.
Wendland MF, Saeed M, Arheden H, Gao DW, Canet E, Bremerich J, Dae MW, Higgins CB. Toward necrotic cell fraction measurement by contrast-enhanced MRI of reperfused ischemically injured myocardium. Acad Radiol. 1998 Apr; 5 Suppl 1:S42-4; discussion S45-6.
DePuey EG, Port S, Wackers FJ, Rozanski A, Botvinick EH, Dae MW, Tamaki N. Nonperfusion applications in nuclear cardiology: report of a task force of the American Society of Nuclear Cardiology. J Nucl Cardiol. 1998 Mar-Apr; 5(2):218-31.
Segall GM, Stepp C, Kadkade PP, Dae MW, Botvinick EH. Fast acquisition of myocardial SPECT images with Tc-99m sestamibi for the diagnosis of coronary artery disease. J Nucl Cardiol. 1997 Sep-Oct; 4(5):358-63.
Dae MW, Lee RJ, Ursell PC, Chin MC, Stillson CA, Moise NS. Heterogeneous sympathetic innervation in German shepherd dogs with inherited ventricular arrhythmia and sudden cardiac death. Circulation. 1997 Aug 19; 96(4):1337-42.
Ellis WS, Eisenberg SJ, Auslander DM, Dae MW, Zakhor A, Lesh MD. Deconvolution: a novel signal processing approach for determining activation time from fractionated electrograms and detecting infarcted tissue. Circulation. 1996 Nov 15; 94(10):2633-40.
Dae MW, O'Connell JW, Botvinick EH, Chin MC. Acute and chronic effects of transient myocardial ischemia on sympathetic nerve activity, density, and norepinephrine content. Cardiovasc Res. 1995 Aug; 30(2):270-80.
Segall GM, Atwood JE, Botvinick EH, Dae MW, Lucas JR. Variability of normal coronary anatomy: implications for the interpretation of thallium-SPECT myocardial perfusion images in single-vessel disease. J Nucl Med. 1995 Jun; 36(6):944-51.
De Marco T, Dae M, Yuen-Green MS, Kumar S, Sudhir K, Keith F, Amidon TM, Rifkin C, Klinski C, Lau D. Iodine-123 metaiodobenzylguanidine scintigraphic assessment of the transplanted human heart: evidence for late reinnervation. J Am Coll Cardiol. 1995 Mar 15; 25(4):927-31.
Foster E, O'Kelly B, LaPidus A, Sandler D, Tucker K, Dae M, Schiller NB, Botvinick EH. Segmental analysis of resting echocardiographic function and stress scintigraphic perfusion: implications for myocardial viability. Am Heart J. 1995 Jan; 129(1):7-14.
Lee MA, Dae MW, Langberg JJ, Griffin JC, Chin MC, Finkbeiner WE, O'Connell JW, Botvinick E, Scheinman MM, Rosenqvist M. Effects of long-term right ventricular apical pacing on left ventricular perfusion, innervation, function and histology. J Am Coll Cardiol. 1994 Jul; 24(1):225-32.
Krishnan R, Lu J, Dae MW, Botvinick EH. Does myocardial perfusion scintigraphy demonstrate clinical usefulness in patients with markedly positive exercise tests? An assessment of the method in a high-risk subset. Am Heart J. 1994 Apr; 127(4 Pt 1):804-16.
Wolfe CL, O'Connell JW, Sievers RE, Cobb C, Dae MW, Botvinick E. Assessment of perfused left ventricular mass in normal, ischemic, and reperfused myocardium by means of single-photon emission computed tomography of technetium-99m isonitrile. Am Heart J. 1993 Dec; 126(6):1275-86.
Newman D, Munoz L, Chin M, Franz M, Herre J, Scheinman MM, Botvinick E, Dae M. Effects of canine myocardial infarction on sympathetic efferent neuronal function: scintigraphic and electrophysiologic correlates. Am Heart J. 1993 Nov; 126(5):1106-12.
Yu KK, Saeed M, Wendland MF, Dae MW, Velasquez-Rocha S, Derugin N, Higgins CB. Comparison of T1-enhancing and magnetic susceptibility magnetic resonance contrast agents for demarcation of the jeopardy area in experimental myocardial infarction. Invest Radiol. 1993 Nov; 28(11):1015-23.
Krishnan R, Lu J, Zhu YY, Dae MW, Botvinick EH. Myocardial perfusion scintigraphy in left bundle branch block: a perspective on the issue from image analysis in a clinical context. Am Heart J. 1993 Sep; 126(3 Pt 1):578-86.
Dae MW, De Marco T, Botvinick EH, O'Connell JW, Hattner RS, Huberty JP, Yuen-Green MS. Scintigraphic assessment of MIBG uptake in globally denervated human and canine hearts--implications for clinical studies. J Nucl Med. 1992 Aug; 33(8):1444-50.
Watters TA, Botvinick EH, Dae MW, Cahalan M, Urbanowicz J, Benefiel DJ, Schiller NB, Goldstone G, Reilly L, Stoney RJ. Comparison of the findings on preoperative dipyridamole perfusion scintigraphy and intraoperative transesophageal echocardiography: implications regarding the identification of myocardium at ischemic risk. J Am Coll Cardiol. 1991 Jul; 18(1):93-100.
Oeff M, Scheinman MM, Abbott JA, Botvinick EH, Griffin JC, Herre JM, Dae MW. Phase image triangulation of accessory pathways in patients undergoing catheter ablation of posteroseptal pathways. Pacing Clin Electrophysiol. 1991 Jun; 14(6):1072-85.
Dae MW, Herre JM, O'Connell JW, Botvinick EH, Newman D, Munoz L. Scintigraphic assessment of sympathetic innervation after transmural versus nontransmural myocardial infarction. J Am Coll Cardiol. 1991 May; 17(6):1416-23.
Rosenqvist M, Isaaz K, Botvinick EH, Dae MW, Cockrell J, Abbott JA, Schiller NB, Griffin JC. Relative importance of activation sequence compared to atrioventricular synchrony in left ventricular function. Am J Cardiol. 1991 Jan 15; 67(2):148-56.
Zhu YY, Chung WS, Botvinick EH, Dae MW, Lim AD, Ports TA, Danforth JW, Wolfe CL, Goldschlager N, Chatterjee K. Dipyridamole perfusion scintigraphy: the experience with its application in one hundred seventy patients with known or suspected unstable angina. Am Heart J. 1991 Jan; 121(1 Pt 1):33-43.
Urbanowicz JH, Shaaban MJ, Cohen NH, Cahalan MK, Botvinick EH, Chatterjee K, Schiller NB, Dae MW, Matthay MA. Comparison of transesophageal echocardiographic and scintigraphic estimates of left ventricular end-diastolic volume index and ejection fraction in patients following coronary artery bypass grafting. Anesthesiology. 1990 Apr; 72(4):607-12.
Mori H, Pisarri TE, Aldea GS, Husseini WK, Dae MW, Stevens MB, Hill AC, Coleridge JC, Coleridge HM, Hoffman JI. Usefulness and limitations of regional cardiac sympathectomy by phenol. Am J Physiol. 1989 Nov; 257(5 Pt 2):H1523-33.
Verrier ED, Crombleholme TM, Sauer L, Longaker M, Langer JC, Flake AW, Dae M, Brem H, Harrison MR. Neonatal model of heterotopic heart transplantation in pigs. J Thorac Cardiovasc Surg. 1989 Jul; 98(1):127-35; discussion 135-6.
Schechtmann N, Botvinick EH, Dae M, Scheinman MM, O'Connell JW, Davis J, Winston S, Schwartz A, Abbott J. The scintigraphic characteristics of ventricular pre-excitation through Mahaim fibers with the use of phase analysis. J Am Coll Cardiol. 1989 Mar 15; 13(4):882-91.
Dae MW, O'Connell JW, Botvinick EH, Ahearn T, Yee E, Huberty JP, Mori H, Chin MC, Hattner RS, Herre JM. Scintigraphic assessment of regional cardiac adrenergic innervation. Circulation. 1989 Mar; 79(3):634-44.
Zhu YY, Lee W, Botvinick E, Dae M, Chatterjee K, Danforth J, Ports T. The clinical and pathophysiologic implications of pain, ST abnormalities, and scintigraphic changes induced during dipyridamole infusion: their relationships to the peripheral hemodynamic response. Am Heart J. 1988 Oct; 116(4):1071-80.
Herre JM, Wetstein L, Lin YL, Mills AS, Dae M, Thames MD. Effect of transmural versus nontransmural myocardial infarction on inducibility of ventricular arrhythmias during sympathetic stimulation in dogs. J Am Coll Cardiol. 1988 Feb; 11(2):414-21.
Botvinick E, Schechtmann N, Dae M, Scheinman M, Davis J, Herre J, Iskikian T, Abbott J. Augmented preexcitation assessed by scintigraphic phase analysis during atrial pacing. Am Heart J. 1987 Oct; 114(4 Pt 1):738-45.
Axelrod RJ, De Marco T, Dae M, Botvinick EH, Chatterjee K. Hemodynamic and clinical evaluation of piroximone, a new inotrope-vasodilator agent, in severe congestive heart failure. J Am Coll Cardiol. 1987 May; 9(5):1124-30.
Canhasi B, Dae M, Botvinick E, Lanzer P, Schechtmann N, Faulkner D, O'Connell W, Schiller N. Interaction of "supplementary" scintigraphic indicators of ischemia and stress electrocardiography in the diagnosis of multivessel coronary disease. J Am Coll Cardiol. 1985 Sep; 6(3):581-8.
Viquerat CE, Hansen RM, Botvinick EH, Dae MW, Wiener-Kronish JP, Matthay MA. Undrained bloody pericardial effusion in the early postoperative period after coronary bypass surgery: a prospective blood pool study. Am Heart J. 1985 Aug; 110(2):335-41.
Wahr DW, Ports TA, Botvinick EH, Dae M, Schechtmann N, Huberty J, Hattner RS, O'Connell JW, Turley K. The effects of coronary angioplasty and reperfusion on distribution of myocardial flow. Circulation. 1985 Aug; 72(2):334-43.
Dae M, Canhasi B, Botvinick E, Olvera S, Schechtmann N, Engelstad B, Hattner R, Schiller N, O'Connell W, Faulkner D. The etiology and implications of dense cavitary "photopenia" on myocardial perfusion scintigraphy. Invest Radiol. 1985 Jul; 20(4):388-92.
Frais M, Botvinick E, Shosa D, O'Connell W, Pacheco Alvarez J, Dae M, Hattner R, Faulkner D. Phase image characterization of localized and generalized left ventricular contraction abnormalities. J Am Coll Cardiol. 1984 Nov; 4(5):987-98.
Botvinick E, Frais M, O'Connell W, Faulkner D, Scheinman M, Morady F, Sung R, Shosa D, Dae M. Phase image evaluation of patients with ventricular pre-excitation syndromes. J Am Coll Cardiol. 1984 Mar; 3(3):799-814.