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UCSF Cardiology
Transforming medicine through innovation and collaboration.
Department of Medicine

Faculty Profiles

Rakesh Mishra
Associate Professor


My research focuses on the identification of serum and imaging biomarkers associated with elevated risk of adverse cardiovascular outcomes in various populations, including patients with coronary artery disease and chronic kidney disease. In addition, I am interested in identifying novel and prognostically meaningful non-invasive measures of cardiac physiology.

I am committed to undergraduate and graduate medical education. I have precepted numerous medical students and IM residents in the Cardiology Clinic at the SFVAMC and on the wards. I spearhead stress testing and Nuclear Cardiology teaching for fellows rotating at the SFVAMC.

Education and Training

Location Degree or Training Specialty Date
Brigham & Women's Hospital, Harvard Medical School Fellowship in Nuclear Cardiology 06/2004
UCSF Fellowship in Cardiology 06/2001
UCSF IM Residency 06/1998
University of Wahington M.D. 05/1995

Awards and Honors

2013   School of Medicine Essential Core Teaching Award, UCSF, 2013-2014
2012   Cardiology Fellows Teaching Award, UCSF, 2012

Recent Articles (28)

Psotka MA, Schiller NB, Whooley MA, Mishra RK. Association of change in 5-year N-terminal fragment of the prohormone brain-type natriuretic peptide with left ventricular structure and function in stable coronary disease. J Cardiovasc Med (Hagerstown). 2018 Feb; 19(2):67-72.

Mishra RK, Judson G, Christenson RH, DeFilippi C, Wu AHB, Whooley MA. The Association of Five-Year Changes in the Levels of N-Terminal Fragment of the Prohormone Brain-Type Natriuretic Peptide (NT-proBNP) with Subsequent Heart Failure and Death in Patients with Stable Coronary Artery Disease: The Heart and Soul Study. Cardiology. 2017; 137(4):201-206.

Ge L, Wu Y, Soleimani M, Khazalpour M, Takaba K, Tartibi M, Zhang Z, Acevedo-Bolton G, Saloner DA, Wallace AW, Mishra R, Grossi EA, Guccione JM, Ratcliffe MB. Moderate Ischemic Mitral Regurgitation After Posterolateral Myocardial Infarction in Sheep Alters Left Ventricular Shear but Not Normal Strain in the Infarct and Infarct Borderzone. Ann Thorac Surg. 2016 May; 101(5):1691-9.

Mishra RK, Yang W, Roy J, Anderson AH, Bansal N, Chen J, DeFilippi C, Delafontaine P, Feldman HI, Kallem R, Kusek JW, Lora CM, Rosas SE, Go AS, Shlipak MG. Kansas City Cardiomyopathy Questionnaire Score Is Associated With Incident Heart Failure Hospitalization in Patients With Chronic Kidney Disease Without Previously Diagnosed Heart Failure: Chronic Renal Insufficiency Cohort Study. Circ Heart Fail. 2015 Jul; 8(4):702-8.

Mishra RK, Tietjens J, Regan M, Whooley MA, Schiller NB. The Prognostic Utility of Echo-Estimated Left Ventricular End-Diastolic Pressure-Volume Relationship in Stable Coronary Artery Disease: The Heart and Soul Study. Echocardiography. 2015 Nov; 32(11):1639-46.

Saha SA, Beatty AL, Mishra RK, Whooley MA, Schiller NB. Usefulness of an Echocardiographic Composite Cardiac Calcium Score to Predict Death in Patients With Stable Coronary Artery Disease (from the Heart and Soul Study). Am J Cardiol. 2015 Jul 01; 116(1):50-8.

Park M, Vittinghoff E, Shlipak MG, Mishra R, Whooley M, Bansal N. Associations of N-terminal pro-B-type natriuretic peptide with kidney function decline in persons without clinical heart failure in the Heart and Soul Study. Am Heart J. 2014 Dec; 168(6):931-9.e2.

Mishra RK, Beatty AL, Jaganath R, Regan M, Wu AH, Whooley MA. B-type natriuretic peptides for the prediction of cardiovascular events in patients with stable coronary heart disease: the Heart and Soul Study. J Am Heart Assoc. 2014 Jul 22; 3(4).

Lee LC, Ge L, Zhang Z, Pease M, Nikolic SD, Mishra R, Ratcliffe MB, Guccione JM. Patient-specific finite element modeling of the Cardiokinetix Parachute(®) device: effects on left ventricular wall stress and function. Med Biol Eng Comput. 2014 Jun; 52(6):557-66.

Ge L, Morrel WG, Ward A, Mishra R, Zhang Z, Guccione JM, Grossi EA, Ratcliffe MB. Measurement of mitral leaflet and annular geometry and stress after repair of posterior leaflet prolapse: virtual repair using a patient-specific finite element simulation. Ann Thorac Surg. 2014 May; 97(5):1496-503.

Mishra RK, Dubin RF. The effects of frequent hemodialysis on left ventricular mass, volumes, and geometry. Clin J Am Soc Nephrol. 2013 Dec; 8(12):2025-7.

Dubin RF, Li Y, He J, Jaar BG, Kallem R, Lash JP, Makos G, Rosas SE, Soliman EZ, Townsend RR, Yang W, Go AS, Keane M, Defilippi C, Mishra R, Wolf M, Shlipak MG. Predictors of high sensitivity cardiac troponin T in chronic kidney disease patients: a cross-sectional study in the chronic renal insufficiency cohort (CRIC). BMC Nephrol. 2013 Oct 22; 14:229.

Shimkunas R, Zhang Z, Wenk JF, Soleimani M, Khazalpour M, Acevedo-Bolton G, Wang G, Saloner D, Mishra R, Wallace AW, Ge L, Baker AJ, Guccione JM, Ratcliffe MB. Left ventricular myocardial contractility is depressed in the borderzone after posterolateral myocardial infarction. Ann Thorac Surg. 2013 May; 95(5):1619-25.

Mishra RK, Li Y, DeFilippi C, Fischer MJ, Yang W, Keane M, Chen J, He J, Kallem R, Horwitz EJ, Rafey M, Raj DS, Go AS, Shlipak MG. Association of cardiac troponin T with left ventricular structure and function in CKD. Am J Kidney Dis. 2013 May; 61(5):701-9.

Mishra RK, Li Y, Ricardo AC, Yang W, Keane M, Cuevas M, Christenson R, deFilippi C, Chen J, He J, Kallem RR, Raj DS, Schelling JR, Wright J, Go AS, Shlipak MG. Association of N-terminal pro-B-type natriuretic peptide with left ventricular structure and function in chronic kidney disease (from the Chronic Renal Insufficiency Cohort [CRIC]). Am J Cardiol. 2013 Feb 01; 111(3):432-8.

Park M, Hsu CY, Li Y, Mishra RK, Keane M, Rosas SE, Dries D, Xie D, Chen J, He J, Anderson A, Go AS, Shlipak MG. Associations between kidney function and subclinical cardiac abnormalities in CKD. J Am Soc Nephrol. 2012 Oct; 23(10):1725-34.

Carrick R, Ge L, Lee LC, Zhang Z, Mishra R, Axel L, Guccione JM, Grossi EA, Ratcliffe MB. Patient-specific finite element-based analysis of ventricular myofiber stress after Coapsys: importance of residual stress. Ann Thorac Surg. 2012 Jun; 93(6):1964-71.

Soleimani M, Khazalpour M, Cheng G, Zhang Z, Acevedo-Bolton G, Saloner DA, Mishra R, Wallace AW, Guccione JM, Ge L, Ratcliffe MB. Moderate mitral regurgitation accelerates left ventricular remodeling after posterolateral myocardial infarction. Ann Thorac Surg. 2011 Nov; 92(5):1614-20.

Mishra RK, Devereux RB, Cohen BE, Whooley MA, Schiller NB. Prediction of heart failure and adverse cardiovascular events in outpatients with coronary artery disease using mitral E/A ratio in conjunction with e-wave deceleration time: the heart and soul study. J Am Soc Echocardiogr. 2011 Oct; 24(10):1134-40.

Mishra RK. Cardiac emergencies in patients with HIV. Emerg Med Clin North Am. 2010 May; 28(2):273-82, Table of Contents.

Chinali M, Aurigemma GP, de Simone G, Mishra RK, Gerdts E, Wachtell K, Boman K, Dahlöf B, Devereux RB. Mitral E wave deceleration time to peak E velocity ratio and cardiovascular outcome in hypertensive patients during antihypertensive treatment (from the LIFE echo-substudy). Am J Cardiol. 2009 Oct 15; 104(8):1098-104.

Mishra RK, Galloway JM, Lee ET, Best LG, Russell M, Roman MJ, Devereux RB. The ratio of mitral deceleration time to E-wave velocity and mitral deceleration slope outperform deceleration time alone in predicting cardiovascular outcomes: the Strong Heart Study. J Am Soc Echocardiogr. 2007 Nov; 20(11):1300-6.

Mishra RK, Kizer JR, Palmieri V, Roman MJ, Galloway JM, Fabsitz RR, Lee ET, Best LG, Devereux RB. Utility of the myocardial performance index in a population with high prevalences of obesity, diabetes, and hypertension: the strong heart study. Echocardiography. 2007 Apr; 24(4):340-7.

Mishra RK, Basson CT. Treatment goals for the management of lipids and inflammation for patients with coronary artery disease. Curr Treat Options Cardiovasc Med. 2007 Feb; 9(1):3-10.

Dorbala S, Giugliano RP, Logsetty G, Vangala D, Mishra R, Crugnale S, Yang D, Di Carli MF. Prognostic value of SPECT myocardial perfusion imaging in patients with elevated cardiac troponin I levels and atypical clinical presentation. J Nucl Cardiol. 2007 Jan; 14(1):53-8.

Skubas N, Brown NI, Mishra R. Diagnostic dilemma: a pacemaker lead inside the left atrium or an echocardiographic beam width artifact? Anesth Analg. 2006 Apr; 102(4):1043-4.

Mishra RK, Dorbala S, Logsetty G, Hassan A, Heinonen T, Schelbert HR, Di Carli MF. Quantitative relation between hemodynamic changes during intravenous adenosine infusion and the magnitude of coronary hyperemia: implications for myocardial perfusion imaging. J Am Coll Cardiol. 2005 Feb 15; 45(4):553-8.

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