Faculty ProfilesJohn Chorba, MD
1001 Potrero Ave, SFGH 100
San Francisco, CA 94110
My interests lie in using chemical tools to probe biological mechanisms of disease, with the ultimate goal of developing a better understanding of heart disease to develop novel therapeutics. Currently, my work focuses on the processing mechanisms of PCSK9, a protein that causes elevated cholesterol levels, so as to develop new drug targets against atherosclerosis.
Education and Training
|Location||Degree or Training||Specialty||Date|
|University of California, San Francisco||Cardiology Fellowship||2014|
|Massachusetts General Hospital||Internal Medicine Residency||2010|
|Harvard Medical School||M.D.||2007|
Awards and Honors
Hellman Fellowship, Hellman Fellows Fund, 2015-2017
ASPIRE Cardiovascular Award, Pfizer, 2015-2018
Catalyst Award, UCSF CTSI, 2015-2016
Pilot Investigator Award, UCSF Academic Senate, 2015-2017
K08 Mentored Clinical Scientist Development Award, NIH/NHLBI, 2015-2020
Research Scholar in Cardiovascular Disease Award, Gilead Sciences, 2013-2016
Loan Repayment Program, NIH/NHLBI, 2013-2017
Ruth L. Kirschstein F32 National Research Service Award, NIH/NHLBI, 2012-2014
Laennec Young Clinician Award, American Heart Association, 2011
Recent Articles (9)
Chorba JS, Galvan AM, Shokat KM. Stepwise processing analyses of the single-turnover PCSK9 protease reveal its substrate sequence specificity and link clinical genotype to lipid phenotype. J Biol Chem. 2017 Dec 19.
Wertheim BM, Aguirre AJ, Bhattacharyya RP, Chorba J, Jadhav AP, Kerry VB, Macklin EA, Motyckova G, Raju S, Lewandrowski K, Hunt DP, Wright DE. An Educational and Administrative Intervention to Promote Rational Laboratory Test Ordering on an Academic General Medicine Service. Am J Med. 2017 Jan; 130(1):47-53.
Chorba JS, Shokat KM. The proprotein convertase subtilisin/kexin type 9 (PCSK9) active site and cleavage sequence differentially regulate protein secretion from proteolysis. J Biol Chem. 2014 Oct 17; 289(42):29030-43.
Li J, Chorba JS, Whelan SP. Vesicular stomatitis viruses resistant to the methylase inhibitor sinefungin upregulate RNA synthesis and reveal mutations that affect mRNA cap methylation. J Virol. 2007 Apr; 81(8):4104-15.
Watterson SH, Carlsen M, Dhar TG, Shen Z, Pitts WJ, Guo J, Gu HH, Norris D, Chorba J, Chen P, Cheney D, Witmer M, Fleener CA, Rouleau K, Townsend R, Hollenbaugh DL, Iwanowicz EJ. Novel inhibitors of IMPDH: a highly potent and selective quinolone-based series. Bioorg Med Chem Lett. 2003 Feb 10; 13(3):543-6.
Dhar TG, Watterson SH, Chen P, Shen Z, Gu HH, Norris D, Carlsen M, Haslow KD, Pitts WJ, Guo J, Chorba J, Fleener CA, Rouleau KA, Townsend R, Hollenbaugh D, Iwanowicz EJ. Quinolone-based IMPDH inhibitors: introduction of basic residues on ring D and SAR of the corresponding mono, di and benzofused analogues. Bioorg Med Chem Lett. 2003 Feb 10; 13(3):547-51.