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UCSF Cardiology
Transforming medicine through innovation and collaboration.
Department of Medicine

Faculty Profiles

John Chorba, MD
Assistant Professor

1001 Potrero Ave, SFGH 100
San Francisco, CA 94110

My interests lie in using chemical tools to probe biological mechanisms of disease, with the ultimate goal of developing a better understanding of heart disease to develop novel therapeutics. Currently, my work focuses on the processing mechanisms of PCSK9, a protein that causes elevated cholesterol levels, so as to develop new drug targets against atherosclerosis.

Education and Training

Location Degree or Training Specialty Date
University of California, San Francisco Cardiology Fellowship 2014
Massachusetts General Hospital Internal Medicine Residency 2010
Harvard Medical School M.D. 2007

Awards and Honors

2015   Hellman Fellowship, Hellman Fellows Fund, 2015-2017
2015   ASPIRE Cardiovascular Award, Pfizer, 2015-2018
2015   Catalyst Award, UCSF CTSI, 2015-2016
2015   Pilot Investigator Award, UCSF Academic Senate, 2015-2017
2015   K08 Mentored Clinical Scientist Development Award, NIH/NHLBI, 2015-2020
2013   Research Scholar in Cardiovascular Disease Award, Gilead Sciences, 2013-2016
2013   Loan Repayment Program, NIH/NHLBI, 2013-2017
2012   Ruth L. Kirschstein F32 National Research Service Award, NIH/NHLBI, 2012-2014
2011   Laennec Young Clinician Award, American Heart Association, 2011

Featured Videos

Recent Articles (9)

Chorba JS, Galvan AM, Shokat KM. Stepwise processing analyses of the single-turnover PCSK9 protease reveal its substrate sequence specificity and link clinical genotype to lipid phenotype. J Biol Chem. 2017 Dec 19.

Wertheim BM, Aguirre AJ, Bhattacharyya RP, Chorba J, Jadhav AP, Kerry VB, Macklin EA, Motyckova G, Raju S, Lewandrowski K, Hunt DP, Wright DE. An Educational and Administrative Intervention to Promote Rational Laboratory Test Ordering on an Academic General Medicine Service. Am J Med. 2017 Jan; 130(1):47-53.

Chorba JS, Shokat KM. The proprotein convertase subtilisin/kexin type 9 (PCSK9) active site and cleavage sequence differentially regulate protein secretion from proteolysis. J Biol Chem. 2014 Oct 17; 289(42):29030-43.

Rost NS, Biffi A, Cloonan L, Chorba J, Kelly P, Greer D, Ellinor P, Furie KL. Brain natriuretic peptide predicts functional outcome in ischemic stroke. Stroke. 2012 Feb; 43(2):441-5.

Dewland TA, Chorba JS, Goldschlager N, Marcus GM. Sustained ventricular fibrillation in a conscious patient. Arch Intern Med. 2011 Jun 13; 171(11):973, 974-5.

Li J, Chorba JS, Whelan SP. Vesicular stomatitis viruses resistant to the methylase inhibitor sinefungin upregulate RNA synthesis and reveal mutations that affect mRNA cap methylation. J Virol. 2007 Apr; 81(8):4104-15.

Watterson SH, Carlsen M, Dhar TG, Shen Z, Pitts WJ, Guo J, Gu HH, Norris D, Chorba J, Chen P, Cheney D, Witmer M, Fleener CA, Rouleau K, Townsend R, Hollenbaugh DL, Iwanowicz EJ. Novel inhibitors of IMPDH: a highly potent and selective quinolone-based series. Bioorg Med Chem Lett. 2003 Feb 10; 13(3):543-6.

Dhar TG, Watterson SH, Chen P, Shen Z, Gu HH, Norris D, Carlsen M, Haslow KD, Pitts WJ, Guo J, Chorba J, Fleener CA, Rouleau KA, Townsend R, Hollenbaugh D, Iwanowicz EJ. Quinolone-based IMPDH inhibitors: introduction of basic residues on ring D and SAR of the corresponding mono, di and benzofused analogues. Bioorg Med Chem Lett. 2003 Feb 10; 13(3):547-51.

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