Faculty ProfilesVasanth Vedantham
Health Sciences Assistant Clinical Professor
1650 Owens Street
CLINICAL INTERESTS: Dr. Vedantham is cardiologist and clinical cardiac electrophysiologist, specializing in treatment of heart rhythm disorders using catheter ablation, pacemaker and defibrillator implantation, and antiarrhythmic medications. Specific conditions include supraventricular tachycardia, atrial fibrillation, atrial flutter, ventricular tachycardia, bradycardia, syncope, and sudden cardiac death. He also implants biventricular devices for cardiac resynchronization therapy in patients with heart failure.
RESEARCH INTERESTS: Dr. Vedantham's research focuses on the molecular biology of the electrical system of the heart. His specific area of interest is understanding how transcription factors, microRNAs, and other regulatory molecules cooperatively determine the electrical properties of different types of heart cell by controlling the differential expression of ion channels in normal development and in heart disease. To address this problem, Dr. Vedantham combines molecular biology techniques with electrophysiological studies in genetically engineered mouse models. His goal is to make advances in basic cardiovascular science that will lead to improvements in the treatment and prevention of arrhythmias.
Recent Articles (10)
Vedantham V, Evangelista M, Huang Y, Srivastava D. Spatiotemporal regulation of an Hcn4 enhancer defines a role for Mef2c and HDACs in cardiac electrical patterning. Dev Biol. 2013 Jan 1; 373(1):149-62.
Qian L, Huang Y, Spencer CI, Foley A, Vedantham V, Liu L, Conway SJ, Fu JD, Srivastava D. In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes. Nature. 2012 May 31; 485(7400):593-8.
Mandyam MC, Vedantham V, Scheinman MM, Tseng ZH, Badhwar N, Lee BK, Lee RJ, Gerstenfeld EP, Olgin JE, Marcus GM. Alcohol and vagal tone as triggers for paroxysmal atrial fibrillation. Am J Cardiol. 2012 Aug 1; 110(3):364-8.
Ieda M, Fu JD, Delgado-Olguin P, Vedantham V, Hayashi Y, Bruneau BG, Srivastava D. Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell. 2010 Aug 6; 142(3):375-86.
Zhao Y, Ransom JF, Li A, Vedantham V, von Drehle M, Muth AN, Tsuchihashi T, McManus MT, Schwartz RJ, Srivastava D. Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell. 2007 Apr 20; 129(2):303-17.